Technical University of Munich
Lehrstuhl für Bioorganische Chemie (Prof. Sieber)
Ernst-Otto-Fischer-Str. 8
85748 Garching b. München
Multiresistant bacteria pose a major threat to human health. With numerous potent drugs discovered in the “golden age” of antibiotics in the mid of the 20th century, new developments have dramatically declined while strains resistant to common antibiotics are on the rise. Since many of the antibiotics currently in use focus on a rather narrow scope of cellular targets, multiple resistance strategies have already evolved. Given the vast number of essential proteins in bacteria there is a huge potential to decipher unprecedented antibiotic targets yet lacking resistance strategies.
Our goal is to identify unprecedented antibacterial targets beyond the scope of current antibiotics and to exploit these for chemical manipulation. For this we apply a multi-disciplinary strategy comprising synthetic chemistry, functional proteomics, microbiology and protein biochemistry techniques in the following sections: Novel antibacterial targets, natural product mode of action and chemical proteome mining.
Chemistry - A European Journal
Abstract: Glucosinolates (GSLs) are plant secondary metabolites that release bioactive isothiocyanates (ITCs) upon myrosinase-mediated activation. While ITCs display diverse antimicrobial and chemoprotective…
Nature Microbiology
Abstract: Metronidazole is a front-line drug for the treatment of Helicobacter pylori infections. However, its mode of action and cellular targets are poorly defined, and higher dosing and combination therapies…
Chemical Science
Abstract: Machine learning accelerates molecular discovery and relies heavily on standardised benchmark datasets to evaluate computational performance. To learn transferable structure–activity relationships…
Lab on a Chip
Abstract: Proteomic sample preparation for liquid chromatography-tandem mass spectrometry (LC-MS/MS) is increasingly addressed by automated approaches. However, in clinical settings for precision medicine,…
ACS Chemical Biology
Abstract: Ianthelliformisamines (Ian) represent a poorly characterized natural product class reported to inhibit Gram-negative bacteria such as Escherichia coli. Given the current antibiotic crisis, revisiting…
Journal of the American Chemical Society
Abstract: Pyrroloquinoline quinone (PQQ) is a bacterial redox cofactor enabling enzyme catalysis in various sugar and alcohol dehydrogenases. However, its proposed additional role as a “longevity vitamin” lacks…
Journal of Natural Products
Abstract: Microketide A and B are fungal polyketides reported to display potent activity against Gram-negative pathogens, yet the lack of synthetic access has prevented detailed investigation of their mode of…
Pharmaceuticals
Abstract: The fluoroquinolone (FQ) class of antibiotics includes the world’s most prescribed antibiotics such as ciprofloxacin, levofloxacin, and ofloxacin that are known for their low bacterial resistance.…
Nature Communications
Abstract: Fungal diseases impact the lives of a millions of people across the globe, and with our current repertoire of therapeutic options dwindling, effective treatment strategies are urgently needed.…
Cell Chemical Biology
Abstract: Antimicrobial resistance is a threat to human health rendering current first-line antibiotics ineffective. New agents overcoming resistance mechanisms are urgently needed to guarantee successful…
| Title | Dates | Duration | Type | Lecturer (assistant) |
|---|---|---|---|---|
| Groupseminar - Prof. Sieber |
|
2 | SE | |
| Method Seminar Proteomic Mass Spectrometry |
|
2 | SE | |
| Research Internship with Focus on Chemical Aspects (CH0510) |
|
8 | FO | |
| Research Laboratory Course for Biochemists (CH0943) |
|
8 | FO | |
| Structure of Organic Compounds (CH0109) |
|
3 | VO | |
| Structure of Organic Compounds, Exercises (CH0109) |
|
1 | UE | |
| Structure of Organic Compounds, Tutorials (CH0109 / CH0864) |
|
1 | TT |
| Title | Dates | Duration | Type | Lecturer (assistant) |
|---|---|---|---|---|
| Bioorganic Chemistry (CH3039a) |
|
2 | VI | |
| Groupseminar - Prof. Sieber |
|
2 | SE | |
| Method Seminar Proteomic Mass Spectrometry |
|
2 | SE | |
| Milestones of biological chemistry (Seminar/Journal-Club) (CH3039b) |
|
1 | VI | |
| Research Internship with Focus on Chemical Aspects (CH0510) |
|
8 | FO | |
| Research Laboratory Course for Biochemists (CH0943) |
|
8 | FO |