Technical University of Munich
Chair of Biomolecular NMR-Spectroscopy (Prof. Sattler)
Lichtenbergstr. 4
85748 Garching b. München
We study the structure, interactions and dynamics of biological macromolecules in solution using Nuclear Magnetic Resonance (NMR) spectroscopy and integrative structural biology.
Molecular mechanisms and regulation of proteins and RNAs in RNA-based gene regulation (alternative splicing and non-coding RNA pathways), and cellular signaling (molecular chaperones, peroxisome biogenesis), are unraveled by combining NMR with X-ray crystallography, small angle scattering (SAXS/SANS), cryo-EM and biophysical techniques.
Structure based drug discovery is used for the development of small molecule-based therapeutics.
Links:
Cell
Abstract: Ferroptosis, driven by uncontrolled peroxidation of membrane phospholipids, is distinct from other cell death modalities because it lacks an initiating signal and is surveilled by endogenous…
Molecular Cell
Abstract: The Hsp90 molecular chaperone system is regulated by numerous co-chaperones that modulate its function. In Saccharomyces cerevisiae , most of these cofactors can be deleted without affecting…
Structure
Abstract: Incorporating metal cofactors into computationally designed protein scaffolds provides a versatile route to novel protein functions, including the potential for new-to-nature enzyme catalysis.…
Journal of the American Chemical Society
Abstract: The molecular chaperone Hsp90 is an abundant and essential homodimer that supports the stability and folding of hundreds of client proteins in cells. Its C-terminal domain (CTD) mediates dimerization…
Proceedings of the National Academy of Sciences of the United States of America
Abstract: PEX19 is a cytosolic receptor that directs membrane proteins posttranslationally to peroxisomes, as well as to mitochondria, lipid droplets, and the endoplasmic reticulum. A comprehensive Trypanosoma…
Cell
Abstract: Recognition of exogenous RNA by Toll-like receptors (TLRs) is central to pathogen defense. Using two distinct binding pockets, TLR7 and TLR8 recognize RNA degradation products generated by…
Nucleic Acids Research
Abstract: Adenosine-to-inosine (A-to-I) editing is a highly abundant modification of double-stranded RNA (dsRNA) and plays an important role in posttranscriptional gene regulation. Editing of multiple inosines…
MedChemComm
Abstract: Protein-protein interactions (PPIs) are key regulators of various cellular processes. Modulating PPIs with small molecules has gained increasing attention in drug discovery, particularly targeting the…
Angewandte Chemie - International Edition
Abstract: The engineered lipocalin Colchicalin binds the clinically relevant plant toxin colchicine with picomolar affinity. X-ray structures revealed major loop rearrangements at the open end of the β-barrel…
Proceedings of the National Academy of Sciences of the United States of America
Abstract: The chloroplast genome encodes key components of the photosynthetic light reaction machinery as well as the large subunit of the enzyme central for carbon fixation,…
| Title | Dates | Duration | Type | Lecturer (assistant) |
|---|---|---|---|---|
| Biological Chemistry (CH3181a, CH0448a) |
|
2 | VO | |
| Biological Chemistry, Exercise (CH0448b) |
|
2 | UE | |
| Biomolecular NMR-Spectroscopy (CH3184a) |
|
2 | VO | |
| Lecture Series: Bayerisches NMR Zentrum (BNMRZ) |
|
2 | KO | |
| Physical Biochemistry, Seminar (CH0410b) |
|
2 | SE | |
| Research Internship Biochemistry 1 (CH0554) |
|
16 | FO | |
| Research Internship Biochemistry 2 (CH0555) |
|
12 | FO | |
| Research Internship with Focus on Chemical Aspects (CH0510) |
|
8 | FO | |
| Research Laboratory Course for Biochemists (CH0943) |
|
8 | FO | |
| Research Seminar |
|
4 | SE |