Technical University of Munich
Assistant Professorship of Analytical Chemistry (Prof. Strittmatter)
Lichtenbergstr. 4
85748 Garching b. München
Our research focusses on the use of ambient mass spectrometry (MS) methods and imaging mass spectrometry to perform in situ analysis of complex biological samples and spatial metabolomics. We work with very diverse sample types ranging from soils, plants and foods over to cell and organoid cultures as well as preclinical and clinical tissues, thereby focusing on MS method development and implementation of novel applications.
We work predominantly in two areas:
i) the characterization of biofilms using multimodal imaging.
Our group develops analytical methods that allow the assessment of the spatial metabolic heterogeneity in biofilms in order to improve our capabilities to manipulate them. We develop and use spatial metabolomic methods to identify metabolically distinct areas and investigate how these change under stress.
ii) the characterization of tissue and cellular metabolic heterogeneity and drug distribution.
To understand cellular metabolic adaptations in health and disease as well as drug distribution into different cell and tissue compartments, we develop analytical methods to perform screening of cell cultures as well as imaging workflows to holistically characterize tissues and cells in their native environment.
Mass spectrometry imaging (MSI) is a powerful tool for spatially resolved multiomics analysis of tissue samples in clinical research. However, its proteomics application is still limited due to…
Spot blotch of barley (Hordeum vulgare L.), caused by Bipolaris sorokiniana, is responsible for major losses in crop yield. Breeding-resistant barley varieties have proven to be an effective…
Lasers are commonly used for mass spectrometric applications to perform laser ablation-desorption and ionization; however, the use of visible light is not very common. Here, we report a commercially…
The growing demand for energy and the excessive use of fossil fuels represents one of the main challenges for humanity. Storing solar energy in the form of chemical bonds to generate solar fuels or…
A direct headspace injection method is presented and optimized for the analysis of volatile organic compounds (VOCs) using dielectric barrier discharge ionization-mass spectrometry (DBDI-MS),…
The growing demand for energy and the excessive use of fossil fuels represents one of the main challenges for humanity. Storing solar energy in the form of chemical bonds to generate solar fuels or…
Fast and reliable identification of bacteria directly in clinical samples is a critical factor in clinical microbiological diagnostics. Current approaches require time-consuming bacterial isolation…
The use of three-dimensional self-assembled metallacages (MCgs) as multimodal drug platforms holds great promise. However, the synthesis of MCgs with increased complexity and functionality is a great…
With increased use of mass spectrometry imaging (MSI) in support of pharmaceutical research and development, there are opportunities to develop analytical pipelines that incorporate exploratory…
| Title | Dates | Duration | Type | Lecturer (assistant) |
|---|---|---|---|---|
| Analytical Chemistry (CH0107) |
|
2 | VO | |
| Current topics in in-situ mass spectrometry |
|
2 | SE | |
| Mass Spectrometry Imaging: Fundamentals and Hands-on Exercises |
|
3 | VI | |
| Modern Mass Spectrometry: Instrumentation and Applications (CH3127) |
|
3 | VI | |
| Research Internship Analytical Chemistry (NAT0152) |
|
12 | FO | |
| Research Internship Analytical Chemistry (NAT0172) |
|
12 | FO |