Prof. Nicole Strittmatter

Curriculum Vitae

Research

Our research focusses on the use of ambient mass spectrometry (MS) methods and imaging mass spectrometry to perform in situ analysis of complex biological samples and spatial metabolomics. We work with very diverse sample types ranging from soils, plants and foods over to cell and organoid cultures as well as preclinical and clinical tissues, thereby focusing on MS method development and implementation of novel applications.

We work predominantly in two areas: 

i) the characterization of biofilms using multimodal imaging.

Our group develops analytical methods that allow the assessment of the spatial metabolic heterogeneity in biofilms in order to improve our capabilities to manipulate them. We develop and use spatial metabolomic methods to identify metabolically distinct areas and investigate how these change under stress. 

ii) the characterization of tissue and cellular metabolic heterogeneity and drug distribution. 

To understand cellular metabolic adaptations in health and disease as well as drug distribution into different cell and tissue compartments, we develop analytical methods to perform screening of cell cultures as well as imaging workflows to holistically characterize tissues and cells in their native environment.