Technical University of Munich
Professur für Analytische Chemie (Prof. Strittmatter)
Lichtenbergstr. 4
85748 Garching b. München
Our research focusses on the use of ambient mass spectrometry (MS) methods and imaging mass spectrometry to perform in situ analysis of complex biological samples and spatial metabolomics. We work with very diverse sample types ranging from soils, plants and foods over to cell and organoid cultures as well as preclinical and clinical tissues, thereby focusing on MS method development and implementation of novel applications.
We work predominantly in two areas:
i) the characterization of biofilms using multimodal imaging.
Our group develops analytical methods that allow the assessment of the spatial metabolic heterogeneity in biofilms in order to improve our capabilities to manipulate them. We develop and use spatial metabolomic methods to identify metabolically distinct areas and investigate how these change under stress.
ii) the characterization of tissue and cellular metabolic heterogeneity and drug distribution.
To understand cellular metabolic adaptations in health and disease as well as drug distribution into different cell and tissue compartments, we develop analytical methods to perform screening of cell cultures as well as imaging workflows to holistically characterize tissues and cells in their native environment.
Chemistry-Methods
Abstract: Desorption electrospray ionisation mass spectrometry (DESI-MS) can profile cultured cells with minimal sample preparation, but salt carryover and wash-induced leakage often reduce metabolite coverage…
Analytical and Bioanalytical Chemistry
Abstract: Wash protocols are a simple, commonly used approach to enhance the detectability of low-abundant or poorly ionisable compounds in mass spectrometry imaging (MSI). The washing procedures aim to enhance…
BioSpektrum
Chemical Science
Abstract: Mass spectrometry imaging (MSI) is a versatile technique for spatially resolved multi-omics analysis in clinical research. However, its proteomic applications remain constrained by issues such as poor…
BMC Medicine
Abstract: Background: Treatment of head and neck squamous cell carcinoma (HNSCC) remains challenging and the survival rates of affected patients remain poor. A three-dimensional organotypic co-culture (3D-OTC)…
Angewandte Chemie - International Edition
Abstract: The growing demand for energy and the excessive use of fossil fuels represents one of the main challenges for humanity. Storing solar energy in the form of chemical bonds to generate solar fuels or…
Journal of agricultural and food chemistry
Abstract: Spot blotch of barley (Hordeum vulgare L.), caused by Bipolaris sorokiniana, is responsible for major losses in crop yield. Breeding-resistant barley varieties have proven to be an effective…
Angewandte Chemie International Edition in English
Abstract: The growing demand for energy and the excessive use of fossil fuels represents one of the main challenges for humanity. Storing solar energy in the form of chemical bonds to generate solar fuels or…
ACS Central Science
Abstract: Mass spectrometry imaging (MSI) is a powerful tool for spatially resolved multiomics analysis of tissue samples in clinical research. However, its proteomics application is still limited due to…
Journal of the American Society for Mass Spectrometry
Abstract: A direct headspace injection method is presented and optimized for the analysis of volatile organic compounds (VOCs) using dielectric barrier discharge ionization-mass spectrometry (DBDI-MS),…
| Title | Dates | Duration | Type | Lecturer (assistant) |
|---|---|---|---|---|
| Analytical Chemistry (CH0107) |
|
2 | VO | |
| Current topics in in-situ mass spectrometry |
|
2 | SE | |
| Mass Spectrometry Imaging: Fundamentals and Hands-on Exercises |
|
3 | VI | |
| Modern Mass Spectrometry: Instrumentation and Applications (CH3127) |
|
3 | VI | |
| Research Internship Analytical Chemistry (NAT0152) |
|
12 | FO | |
| Research Internship Analytical Chemistry (NAT0172) |
|
12 | FO |