Technische Universität München
Lehrstuhl für Bioorganische Chemie (Prof. Sieber)
Ernst-Otto-Fischer-Str. 8
85748 Garching b. München
Multiresistant bacteria pose a major threat to human health. With numerous potent drugs discovered in the “golden age” of antibiotics in the mid of the 20th century, new developments have dramatically declined while strains resistant to common antibiotics are on the rise. Since many of the antibiotics currently in use focus on a rather narrow scope of cellular targets, multiple resistance strategies have already evolved. Given the vast number of essential proteins in bacteria there is a huge potential to decipher unprecedented antibiotic targets yet lacking resistance strategies.
Our goal is to identify unprecedented antibacterial targets beyond the scope of current antibiotics and to exploit these for chemical manipulation. For this we apply a multi-disciplinary strategy comprising synthetic chemistry, functional proteomics, microbiology and protein biochemistry techniques in the following sections: Novel antibacterial targets, natural product mode of action and chemical proteome mining.
Chemistry - A European Journal
Abstract: Glucosinolates (GSLs) are plant secondary metabolites that release bioactive isothiocyanates (ITCs) upon myrosinase-mediated activation. While ITCs display diverse antimicrobial and chemoprotective…
ACS Chemical Biology
Abstract: Ianthelliformisamines (Ian) represent a poorly characterized natural product class reported to inhibit Gram-negative bacteria such as Escherichia coli. Given the current antibiotic crisis, revisiting…
Nature Microbiology
Abstract: Metronidazole is a front-line drug for the treatment of Helicobacter pylori infections. However, its mode of action and cellular targets are poorly defined, and higher dosing and combination therapies…
Journal of the American Chemical Society
Abstract: Pyrroloquinoline quinone (PQQ) is a bacterial redox cofactor enabling enzyme catalysis in various sugar and alcohol dehydrogenases. However, its proposed additional role as a “longevity vitamin” lacks…
Journal of Natural Products
Abstract: Microketide A and B are fungal polyketides reported to display potent activity against Gram-negative pathogens, yet the lack of synthetic access has prevented detailed investigation of their mode of…
JACS Au
Abstract: The escalating crisis of multiresistant bacteria demands the rapid discovery of novel antibiotics that transcend the limitations imposed by the biased chemical space of current libraries. To address…
ACS Applied Materials and Interfaces
Abstract: Achieving reversible stiffening of biopolymer networks in a controlled manner remains a challenging topic in materials science, especially when trying to assess the following changes in mechanical…
Journal of Cheminformatics
Abstract: Abstract: Accurate prediction of drug–target interactions is critical for advancing drug discovery. By reducing time and cost, machine learning and deep learning can accelerate this laborious…
Cell Death Discovery
Abstract: Natural compounds are a valuable source of highly active biomolecules for the discovery of innovative drug targets as well as drug leads. The natural compound neocarzilin A (NCA) exhibits pronounced…
Angewandte Chemie - International Edition
Abstract: Fluoroquinolones (FQs) are an important class of potent broad-spectrum antibiotics. However, their general use is more and more limited by adverse side effects. While general mechanisms for the…
| Titel | Termine | Dauer | Art | Vortragende/r (Mitwirkende/r) |
|---|---|---|---|---|
| Bioorganische Chemie (CH3039a) |
|
2 | VI | |
| Forschungspraktikum für Studierende der Biochemie (CH0943) |
|
8 | FO | |
| Forschungspraktikum mit chemischem Schwerpunkt (CH0510) |
|
8 | FO | |
| Frontiers in Chemical Biology (CH3039b) |
|
1 | VI | |
| Methodenseminar Proteomische Massenspektrometrie |
|
2 | SE | |
| Mitarbeiterseminar Prof. Sieber |
|
2 | SE |