Technical University of Munich
Professur für Zelluläre Proteinbiochemie (Prof. Feige)
Lichtenbergstr. 4
85748 Garching b. München
We aim to understand the principles that underly protein biogenesis in the cell and to translate these insights into novel approaches for medicine and biotechnology. To achieve this, we use an interdisciplinary approach from in vitro protein biochemistry to mammalian cell biology and molecular immunology.
One major research focus in our lab are cytokines, immune signaling proteins. We investigate how cells support and control their structure formation, which underlies their biological functionality. At the same time, we use these insights to rationally design and engineer new immune-modulatory biologics and approaches for biotechnology.
Membrane proteins allow cells to interact and are the most common drug targets. Their incorrect structure formation is a widespread driver of disease. The second major research focus of our lab is thus to understand how cells produce their diverse membrane protein repertoire and which molecular machineries cells use to support and control membrane protein biogenesis.
Cellular and Molecular Life Sciences
Abstract: KDEL receptors (KDELRs) prevent the secretion of soluble chaperones and enzymes meant to reside in the endoplasmic reticulum. While a single KDELR exists in yeast (ERD2), three variants are present in…
Biochimica et Biophysica Acta - Molecular Cell Research
Abstract: Cytokines of the interleukin 12 (IL-12) family are secreted by cells of the innate immune system to regulate adaptive immune responses. IL-12 family cytokines are heterodimers composed of an α- and a…
Nature Communications
Abstract: Binding of the surrogate light chain (SLC) to the heavy chain (HC) of the pre-B cell receptor (preBCR) is an important quality control checkpoint during B cell development as roughly 50% of the…
Nature Communications
Abstract: Structure formation of membrane proteins is error-prone and thus requires chaperones that oversee this essential process in cell biology. The ER membrane protein complex (EMC) is well-defined as a…
Science Immunology
Abstract: The molecular mechanisms by which worm parasites evade host immunity are incompletely understood. In a mouse model of intestinal helminth infection using Heligmosomoides polygyrus bakeri (Hpb), we…
Biological Chemistry
Abstract: Protein-based drugs are a mainstay of modern medicine. In contrast to antibodies, most of these need highly individualized production processes which often limits their development. Here, we develop…
Biological Chemistry
Science Advances
Abstract: Interleukins are secreted proteins that regulate immune responses. Among these, the interleukin 12 (IL-12) family holds a central position in inflammatory and infectious diseases. Each family member…
Nature Communications
Abstract: Systemic antibody light chain (AL) amyloidosis is characterized by deposition of amyloid fibrils. Prior to fibril formation, soluble oligomeric AL protein has a direct cytotoxic effect on…
Communications Biology
Abstract: The intracellular bacterial pathogen Coxiella burnetii evades the host response by secreting effector proteins that aid in establishing a replication-friendly niche. Bacterial filamentation induced by…
| Title | Dates | Duration | Type | Lecturer (assistant) |
|---|---|---|---|---|
| Cell Biology 2 (Lecture) |
|
2 | VO | |
| Cell Biology, Exercise (CH0434) |
|
2 | UE | |
| Cellular Biochemistry 1, Lecture (CH0663) |
|
3 | VI | |
| Groupseminar - Prof. Feige |
|
2 | SE | |
| Internship Cellular Biochemistry |
|
6 | PR | |
| Research Internship Biochemistry 1 (CH0554) |
|
16 | FO | |
| Research Internship Biochemistry 2 (CH0555) |
|
12 | FO | |
| Research Laboratory Course for Biochemists (CH0943) |
|
8 | FO | |
| Special Aspects of Biochemistry |
|
7 | MT | |
| Working Group for Cellular Protein Biochemistry, Literature Seminar |
|
2 | SE |
| Title | Dates | Duration | Type | Lecturer (assistant) |
|---|---|---|---|---|
| Analysis of Scientific Literature (CH5041) |
|
5 | SE | |
| Groupseminar - Prof. Feige |
|
2 | SE | |
| Internship Cellular Biochemistry (CH0951) |
|
6 | PR | |
| Laboratory Course in Biochemistry (CH0936) |
|
3 | PR | |
| Physical Biochemistry, Seminar (CH0410b) |
|
2 | SE | |
| Research Internship Biochemistry 1 (CH0554) |
|
16 | FO | |
| Research Internship Biochemistry 2 (CH0555) |
|
12 | FO | |
| Research Laboratory Course for Biochemists (CH0943) |
|
8 | FO | |
| Special Aspects of Biochemistry |
|
7 | MT | |
| Working Group for Cellular Protein Biochemistry, Literature Seminar |
|
2 | SE |