Optimal arrangements of enzymes

We study how the spatial arrangement and coordination of enzymes determines the efficiency of a multi-step reaction. These spatial arrangements can be natural (as in biomolecular complexes) or engineered with the modern methods of bio-nanotechnology. In both cases, fundamental functional tradeoffs emerge, which must be characterized to understand the optimization of such systems.


A. Buchner, F. Tostevin, and U. Gerland (2013),
Clustering and optimal arrangement of enzymes in reaction-diffusion systems
Physical Review Letters 110, 208104.                   

A. Buchner, F. Tostevin, F. Hinzpeter and U. Gerland (2013), 
Optimization of collective enzyme activity via spatial localization
J. Chem. Phys. 139, 135101