Technische Universität München
Lehrstuhl für Biomolekulare NMR-Spektroskopie (Prof. Sattler)
Lichtenbergstr. 4
85748 Garching b. München
We study the structure, interactions and dynamics of biological macromolecules in solution using Nuclear Magnetic Resonance (NMR) spectroscopy and integrative structural biology.
Molecular mechanisms and regulation of proteins and RNAs in RNA-based gene regulation (alternative splicing and non-coding RNA pathways), and cellular signaling (molecular chaperones, peroxisome biogenesis), are unraveled by combining NMR with X-ray crystallography, small angle scattering (SAXS/SANS), cryo-EM and biophysical techniques.
Structure based drug discovery is used for the development of small molecule-based therapeutics.
Links:
Proceedings of the National Academy of Sciences of the United States of America
Abstract: PEX19 is a cytosolic receptor that directs membrane proteins posttranslationally to peroxisomes, as well as to mitochondria, lipid droplets, and the endoplasmic reticulum. A comprehensive Trypanosoma…
Molecular Cell
Abstract: The Hsp90 molecular chaperone system is regulated by numerous co-chaperones that modulate its function. In Saccharomyces cerevisiae , most of these cofactors can be deleted without affecting…
Cell
Abstract: Ferroptosis, driven by uncontrolled peroxidation of membrane phospholipids, is distinct from other cell death modalities because it lacks an initiating signal and is surveilled by endogenous…
Structure
Abstract: Incorporating metal cofactors into computationally designed protein scaffolds provides a versatile route to novel protein functions, including the potential for new-to-nature enzyme catalysis.…
Cell
Abstract: Recognition of exogenous RNA by Toll-like receptors (TLRs) is central to pathogen defense. Using two distinct binding pockets, TLR7 and TLR8 recognize RNA degradation products generated by…
ACS Applied Optical Materials
Abstract: Protein-protein interactions regulate essentially all cellular processes. Understanding these interactions, including the quantification of binding parameters, is crucial for unraveling the molecular…
Cell Host and Microbe
Abstract: Hospital-acquired pneumonia caused by Staphylococcus aureus is associated with patient morbidity and mortality, despite adequate antibiotic therapy. This illustrates the need for treatments beyond…
Cell Host and Microbe
Abstract: Hospital-acquired pneumonia caused by Staphylococcus aureus is associated with patient morbidity and mortality, despite adequate antibiotic therapy. This illustrates the need for treatments beyond…
ACS Applied Optical Materials
Abstract: Protein-protein interactions regulate essentially all cellular processes. Understanding these interactions, including the quantification of binding parameters, is crucial for unraveling the molecular…
RSC Medicinal Chemistry
Abstract: Protein-protein interactions (PPIs) are key regulators of various cellular processes. Modulating PPIs with small molecules has gained increasing attention in drug discovery, particularly targeting the…
| Titel | Termine | Dauer | Art | Vortragende/r (Mitwirkende/r) |
|---|---|---|---|---|
| Biologische Chemie (CH3181a, CH0448a) |
|
2 | VO | |
| Biologische Chemie, Übung (CH0448b) |
|
2 | UE | |
| Biomolecular NMR-Spectroscopy (CH3184a) |
|
2 | VO | |
| Forschungspraktikum Biochemie 1 (CH0554) |
|
16 | FO | |
| Forschungspraktikum Biochemie 2 (CH0555) |
|
12 | FO | |
| Forschungspraktikum für Studierende der Biochemie (CH0943) |
|
8 | FO | |
| Forschungspraktikum mit chemischem Schwerpunkt (CH0510) |
|
8 | FO | |
| Physikalische Biochemie, Vortragsseminar (CH0410b) |
|
2 | SE | |
| Seminar für wissenschaftliche Mitarbeiter |
|
4 | SE | |
| Vortragsreihe: Bayerisches NMR Zentrum (BNMRZ) |
|
2 | KO |