Prof. Johannes Buchner


Foto von Johannes Buchner

Prof. Dr. rer. nat. habil. Johannes Buchner

Technische Universität München

Lehrstuhl für Biotechnologie (Prof. Buchner)

Postadresse

Postal:
Ernst-Otto-Fischer-Str. 8
85748 Garching b. München

Research

Mechanisms of Protein Folding

Proteins are involved in almost all biological processes, and their function depends primarily on the correct three-dimensional folding of the polypeptide chain. However, these structures must be dynamic and flexible, to exercise their biological function. As a result, the intrinsic stability of proteins is usually low. As the protein concentration in the cell is very high, this can lead to the interaction of partially folded proteins enhancing their non-specific aggregation. To counteract these limitations, cells have evolved a machinery of molecular chaperones which supports the folding of proteins. We aim for the characterization of spontaneous and chaperone-assisted protein folding and association with a view to define molecular mechanisms and biotechnological applications.

We are engaged in 3 major research areas.

- Analysis of the heat shock protein 90 and 70 (Hsp90, Hsp70) family 

- Small heat shock proteins (sHsps)

- Antibodies as bio-therapeutics and antibody-based diseases (AL).

Winter term 2023/24

TitleDatesDurationTypeLecturer (assistant)
Advanced Laboratory Course in Biochemistry (CH0221)Link5PR
Analysis of Scientific Literature (CH5041)Link5SE
Biological Chemistry Practical Course (NAT0011)Link5PR
Biology for Chemists (CH0106)Link3VI
Elective Subject Research Laboratory Course for Biochemistry (CH0438)Link4PR
Excursion (CH0556b)Link1EX
GoBiochem SeminarLink2SE
Internship Cellular Biochemistry (CH0951)Link6PR
Lab Rotation Molecular Biology and Protein Biology (CH3182)Link10FO
Lab Rotation Molecular Biology and Protein Biology (CH3182)Link16FO
Laboratory Course in Biochemistry (CH0936)Link3PR
Laboratory Course in Biochemistry (Seminar) (CH0936)Link1SE
Physical Biochemistry, Lab Course (CH0410a)Link3PR
Physical Biochemistry, Seminar (CH0410b)Link2SE
Research Internship Biochemistry 1 (CH0554)Link16FO
Research Internship Biochemistry 2 (CH0555)Link12FO
Research Internship in Bioprocess EngineeringLink12PR
Research Internship in Chemical Subsidiary Subject (CH0440)Link4PR
Research Internship with Focus on Biological Aspects (CH0511)Link8FO
Research Internship with Focus on Chemical Aspects (CH0510)Link8FO
Research Laboratory Course Cellular Biochemistry (CH5147)Link10PR
Research Laboratory Course for Biochemists (CH0943)Link6PR
Research Laboratory Course for Biochemists (CH0943)Link8FO
Research Laboratory Course in Biological Chemistry 1 (CH0554)Link10PR
Research Laboratory Course in Biological Chemistry 2 (CH0555)Link8PR
Research Laboratory Course in Molecular Biology and Protein Biology (CH5179)Link5PR
Research Laboratory Course with Focus in Biology (CH0511)Link6PR
Research Laboratory Course with Focus in Chemistry (CH0510)Link6PR
Scientific Literature SeminarLink2SE
Scientific Research SeminarLink1SE
Self-Study of Special Aspects of Biochemistry (CH0556)Link1MT
Seminar Biochemistry (for Biologists)Link2SE
Special Aspects of BiochemistryLink7MT