Prof. Bernd Reif

Curriculum Vitae

Research

Structure and dynamics of amyloid fibrils

Our group is interested in the structural characterization of biomolecules using MAS solid-state and solution-state NMR spectroscopy, with focus on amyloidogenic peptides and proteins, and chaperones. Our research is divided into the areas Structural characterization of aggregation inter-mediates and understanding the mechanisms that lead to protein aggregation at atomic resolution, Structure and dynamics of amyloid fibrils, Interactions of small molecules and molecular chaperones which affect the morphology and the toxicity of amyloid aggregate, Investigation of large protein complexes that are not amenable by solution-state NMR or crystallography, Development of methods in MAS solid-state NMR for quantification of structure and dynamics of biomolecules.