Prof. Michael Groll
Structural and Functional Characterization of Protein-Ligand Interactions
Our research focuses on the study of enzymes, their ligands and reaction mechanisms by combining biological, chemical and analytical methods. In particular, we are interested in the functional and structural characterization of protein-protein and protein-ligand interactions, as well as in the development and practical application of biologically active compounds.
The multi-disciplinary approach of our projects includes techniques such as molecular biology, protein chemistry and crystallization, diffraction data collection and evaluation, model building and refinement, structure guided ligand design, chemical synthesis, as well as evaluation of protein-ligand interactions.