Technische Universität München
Lehrstuhl für Biochemie (Prof. Groll)
Ernst-Otto-Fischer-Str. 8
85748 Garching b. München
Our research focuses on the study of enzymes, their ligands and reaction mechanisms by combining biological, chemical and analytical methods. In particular, we are interested in the functional and structural characterization of protein-protein and protein-ligand interactions, as well as in the development and practical application of biologically active compounds.
The multi-disciplinary approach of our projects includes techniques such as molecular biology, protein chemistry and crystallization, diffraction data collection and evaluation, model building and refinement, structure guided ligand design, chemical synthesis, as well as evaluation of protein-ligand interactions.
Non-canonical methylation events generate terpene structures that evade classical biosynthetic predictions, as exemplified by the proposed C16 terpene hegelenether. Here, we show that this natural…
Incorporating metal cofactors into computationally designed protein scaffolds provides a versatile route to novel protein functions, including the potential for new-to-nature enzyme catalysis.…
Closthioamide (CTA) is a potent antibiotic with a unique polythioamide scaffold produced by Ruminiclostridium cellulolyticum . Unlike classical non-ribosomal peptide synthetases (NRPSs), which use…
The proteasome inhibitors bortezomib, carfilzomib, and ixazomib all act by inhibiting multiple active sites of both constitutive proteasomes and immunoproteasomes. These clinical anticancer drugs are…
De novo designed metalloenzymes and photoenzymes are a valuable addition to the biocatalytic toolbox. We previously introduced PhotoLanZymes (PLZ), a family of lanthanide-dependent photoredox enzymes…
Metronidazole is a front-line drug for the treatment of Helicobacter pylori infections. However, its mode of action and cellular targets are poorly defined, and higher dosing and combination therapies…
Terpene synthases usually generate carbocations by either pyrophosphate (PP) elimination (class I) or substrate protonation (class II) to initiate cyclization cascades. By contrast, recent discoveries…
Human sirtuin 2 (SIRT2) is an NAD+ dependant enzyme that has been linked to the pathogenesis of various diseases, making it a promising target for pharmaceutical intervention. This study presents a…
Photorhabdus strains, Gram-negative bacteria pathogenic to insect larvae, produce two signature compounds: the multifunctional isopropylstilbene (IPS), known for its antibiotic, insecticidal, and…
Epoxomicin is a highly potent natural proteasome inhibitor and the structural scaffold for the anticancer drug carfilzomib. The biosynthesis of its α′,β′-epoxyketone warhead involves the flavoenzyme…
| Titel | Termine | Dauer | Art | Vortragende/r (Mitwirkende/r) |
|---|---|---|---|---|
| Arbeitskreisseminar - Prof. Groll |
|
1 | SE | |
| Bioanorganische Chemie (CH0648/CH0953) |
|
2 | VO | |
| Biochemie 3: Biologische Makromoleküle - Struktur und Funktion (CH0950/NAT0013) |
|
2 | VO | |
| Biochemisches Praktikum (CH4121) |
|
6 | PR | |
| Forschungspraktikum Biochemie 1 (CH0554) |
|
16 | FO | |
| Forschungspraktikum Biochemie 2 (CH0555) |
|
12 | FO | |
| Forschungspraktikum für Studierende der Biochemie (CH0943) |
|
8 | FO | |
| Spezielle Aspekte der Biochemie |
|
7 | MT |