Technische Universität München
Lehrstuhl für Neurobiological Engineering (Prof. Westmeyer)
Boltzmannstr. 11
85748 Garching b. München
We focus on biological engineering of genetically controlled molecular sensors and actuators for neuroimaging and -manipulation of organoids and preclinical model organisms to dissect cellular network function and aid future neurotherapies. Please find out more about our work here and here.
Nature Communications
Abstract: Transcriptomics enables comprehensive, multiplexed characterization of cellular states, yet prevailing methods typically require cell fixation or lysis, precluding longitudinal analysis of RNA…
Biofabrication
Abstract: Microelectrode arrays (MEAs) can be used to record extracellular field potentials of cells, enabling investigations on neural or cardiac cellular electrical activity. However, conventionally used 2D…
ACS Applied Materials and Interfaces
Abstract: Flexible, skin-conformable electrodes require materials that combine mechanical robustness, environmental stability, high electrical performance, and biocompatibility. Here, we present a flexible…
Nature Protocols
Abstract: This protocol provides comprehensive guidance for researchers, including those with limited electron microscopy (EM) experience, on the effective use of genetically encoded, multichannel EMcapsulin…
Advanced Functional Materials
Abstract: Magnetic nanoparticles have proven invaluable for biomechanical investigations due to their ability to exert localized forces. However, cellular delivery of exogenous magnetic agents often results in…
Nature Methods
Abstract: Bioluminescence is an attractive alternative to fluorescence for live-cell imaging; however, its low intensity has prevented widespread adoption. Specialized microscopes compensate by sacrificing…
Cell
Abstract: Advanced gene editing methods have accelerated biomedical discovery and hold great therapeutic promise, but safe and efficient delivery of gene editors remains challenging. In this study, we present a…
Journal of Biological Chemistry
Abstract: Emerging molecular therapies introduce enzymatic activity into cells by delivering genes, transcripts, or proteins. Owing to their robust cell-entry capacity, virus-like particles (VLPs) represent a…
Advanced Functional Materials
Abstract: Magnetic nanoparticles have proven invaluable for biomechanical investigations due to their ability to exert localized forces. However, cellular delivery of exogenous magnetic agents often results in…
ACS Sensors
Abstract: Understanding the functional connectivity and behavior of 3D cell cultures and organoids requires monitoring electrical activity across multiple planes. However, traditional planar microelectrode…
