Technische Universität München
Professur für Strukturelle Membranbiochemie (Prof. Hagn)
Lichtenbergstr. 4
85748 Garching b. München
Our research uses nuclear magnetic resonance (NMR) spectroscopy as a main method to investigate the structure, dynamics and function of membrane proteins. This protein class is essential for signal transduction and solute transport across a biological lipid bilayer membrane. To study these biologically important systems in a native membrane environment, we develop lipid bilayer nanodiscs, an advanced and novel membrane mimetic for structural and functional studies.
At the Bavarian NMR Center (BNMRZ) at TUM and Helmholtz Munich we use cutting-edge NMR instrumentation, a large variety of biophysical methods as well as biochemical tools and assays. We apply this toolset to investigate transport proteins in mitochondria and chloroplasts, G-protein coupled receptors (GPCRs) and the mechanism of intramembrane proteolysis. These systems are associated with diseases such as Alzheimer’s, cancer and neurological disorders.
Links:
Nature Communications
Abstract: The voltage-dependent anion channel (VDAC) is the main gateway for metabolites across the mitochondrial outer membrane. VDAC oligomers are connected to apoptosis induced by various stimuli. However,…
Cellulose
Abstract: To be able to support the complex process of wound closure, a biocompatible material is required that combines suitable adhesiveness and stability with the ability to withstand certain biological…
British Journal of Pharmacology
Abstract: G protein-coupled receptors (GPCRs) play a crucial role in cell function by transducing signals from the extracellular environment to the inside of the cell. They mediate the effects of various…
Nachrichten aus der Chemie
Journal of the American Chemical Society
Abstract: High-resolution structural NMR analyses of membrane proteins are challenging due to their large size, resulting in broad resonances and strong signal overlap. Among the isotope labeling methods that…
Cell Reports
Abstract: Bak is a pore-forming Bcl2 protein that induces apoptosis at the outer mitochondrial membrane, which can either proceed via Bak oligomerization or be inhibited by anti-apoptotic Bcl2 proteins, such as…
BioSpektrum
Abstract: Chloroplasts are essential for energy production and metabolism in plants. Metabolites need to be transported across the two envelope membranes of the chloroplast. In contrast to the inner envelope,…
Nature Structural and Molecular Biology
Abstract: Triose phosphates (TPs) are the primary products of photosynthetic CO2 fixation in chloroplasts, which need to be exported into the cytosol across the chloroplast inner envelope (IE) and outer…
Journal of Structural Biology
Abstract: G protein-coupled receptors (GPCRs) are involved in a multitude of cellular signaling cascades and consequently are a prominent target for pharmaceutical drugs. In the past decades, a growing number…
Journal of Molecular Biology
Abstract: Membrane mimetics are essential for structural and functional studies of membrane proteins. A promising lipid-based system are phospholipid nanodiscs, where two copies of a so-called membrane scaffold…
| Titel | Termine | Dauer | Art | Vortragende/r (Mitwirkende/r) |
|---|---|---|---|---|
| Biochemie (CH4117) |
|
2 | VO | |
| Biochemie, Übung (CH4117) |
|
1 | UE | |
| Biophysikalische Chemie (Vorlesung) (CH0263) |
|
2 | VO | |
| Biophysikalische Chemie, Tutorium (CH0263) |
|
1 | UE | |
| Forschungspraktikum Biochemie 1 (CH0554) |
|
16 | FO | |
| Forschungspraktikum Biochemie 2 (CH0555) |
|
12 | FO | |
| Forschungspraktikum für Studierende der Biochemie (CH0943) |
|
8 | FO | |
| Forschungspraktikum mit chemischem Schwerpunkt (CH0510) |
|
8 | FO | |
| Physikalische Biochemie, Vortragsseminar (CH0410b) |
|
2 | SE | |
| Rezeption wissenschaftlicher Literatur (CH5041) |
|
5 | SE | |
| Seminar für wissenschaftliche Mitarbeiter AK Hagn |
|
2 | SE |