Technische Universität München
Lehrstuhl für Organische Chemie II (Prof. Sieber)
Ernst-Otto-Fischer-Str. 8
85748 Garching b. München
Multiresistant bacteria pose a major threat to human health. With numerous potent drugs discovered in the “golden age” of antibiotics in the mid of the 20th century, new developments have dramatically declined while strains resistant to common antibiotics are on the rise. Since many of the antibiotics currently in use focus on a rather narrow scope of cellular targets, multiple resistance strategies have already evolved. Given the vast number of essential proteins in bacteria there is a huge potential to decipher unprecedented antibiotic targets yet lacking resistance strategies.
Our goal is to identify unprecedented antibacterial targets beyond the scope of current antibiotics and to exploit these for chemical manipulation. For this we apply a multi-disciplinary strategy comprising synthetic chemistry, functional proteomics, microbiology and protein biochemistry techniques in the following sections: Novel antibacterial targets, natural product mode of action and chemical proteome mining.
Nature Microbiology
Abstract: Metronidazole is a front-line drug for the treatment of Helicobacter pylori infections. However, its mode of action and cellular targets are poorly defined, and higher dosing and combination therapies…
Journal of Natural Products
Abstract: Microketide A and B are fungal polyketides reported to display potent activity against Gram-negative pathogens, yet the lack of synthetic access has prevented detailed investigation of their mode of…
Chemical Science
Abstract: Treatment of Mycobacterium tuberculosis infections is a challenging task due to long treatment regiments and a growing number of resistant clinical isolates. To identify new antibiotic hits, we…
Cell Chemical Biology
Abstract: Antimicrobial resistance is a threat to human health rendering current first-line antibiotics ineffective. New agents overcoming resistance mechanisms are urgently needed to guarantee successful…
Angewandte Chemie - International Edition
Abstract: Fluoroquinolones (FQs) are an important class of potent broad-spectrum antibiotics. However, their general use is more and more limited by adverse side effects. While general mechanisms for the…
Gut Microbes
Abstract: Helicobacter pylori γ-glutamyltransferase (gGT) is a virulence factor that promotes bacterial colonization and immune tolerance. Although some studies addressed potential functional mechanisms, the…
Pharmaceuticals
Abstract: The fluoroquinolone (FQ) class of antibiotics includes the world’s most prescribed antibiotics such as ciprofloxacin, levofloxacin, and ofloxacin that are known for their low bacterial resistance.…
Journal of Cheminformatics
Abstract: Abstract: Accurate prediction of drug–target interactions is critical for advancing drug discovery. By reducing time and cost, machine learning and deep learning can accelerate this laborious…
Cell Chemical Biology
Abstract: Antimicrobial resistance is a threat to human health rendering current first-line antibiotics ineffective. New agents overcoming resistance mechanisms are urgently needed to guarantee successful…
Angewandte Chemie International Edition in English
Abstract: Fluoroquinolones (FQs) are an important class of potent broad-spectrum antibiotics. However, their general use is more and more limited by adverse side effects. While general mechanisms for the…
| Titel | Termine | Dauer | Art | Vortragende/r (Mitwirkende/r) |
|---|---|---|---|---|
| Bioorganische Chemie (CH3039a) |
|
2 | VI | |
| Forschungspraktikum für Studierende der Biochemie (CH0943) |
|
8 | FO | |
| Forschungspraktikum mit chemischem Schwerpunkt (CH0510) |
|
8 | FO | |
| Frontiers in Chemical Biology (CH3039b) |
|
1 | VI | |
| Methodenseminar Proteomische Massenspektrometrie |
|
2 | SE | |
| Mitarbeiterseminar Prof. Sieber |
|
2 | SE |