Schnelle bakterielle Identifikation durch massenspektrometrische Marker
BioSpektrum
Prof. Nicole Strittmatter
Prof. Dr. Nicole Strittmatter
Technische Universität München
Professur für Analytische Chemie (Prof. Strittmatter)
Postadresse
Lichtenbergstr. 4
85748 Garching b. München
- Tel.: +49 89 289 13321
- Raum: 5402.04.211K
- Homepage
- E-Mail: nicole.strittmatter@tum.de
Research
Our research focusses on the use of ambient mass spectrometry (MS) methods and imaging mass spectrometry to perform in situ analysis of complex biological samples and spatial metabolomics. We work with very diverse sample types ranging from soils, plants and foods over to cell and organoid cultures as well as preclinical and clinical tissues, thereby focusing on MS method development and implementation of novel applications.
We work predominantly in two areas:
i) the characterization of biofilms using multimodal imaging.
Our group develops analytical methods that allow the assessment of the spatial metabolic heterogeneity in biofilms in order to improve our capabilities to manipulate them. We develop and use spatial metabolomic methods to identify metabolically distinct areas and investigate how these change under stress.
ii) the characterization of tissue and cellular metabolic heterogeneity and drug distribution.
To understand cellular metabolic adaptations in health and disease as well as drug distribution into different cell and tissue compartments, we develop analytical methods to perform screening of cell cultures as well as imaging workflows to holistically characterize tissues and cells in their native environment.
62 Publikationen
Optimised Sample Preparation for Metabolic Analysis of Cell Cultures Using DESI-MS
Chemistry-Methods
Abstract: Desorption electrospray ionisation mass spectrometry (DESI-MS) can profile cultured cells with minimal sample preparation, but salt carryover and wash-induced leakage often reduce metabolite coverage…
Commercially Available Blue Diode Laser Engraver Operating at 455 nm as an Affordable LD-REIMS Ionization Source
Analytical Chemistry
Abstract: Lasers are commonly used for mass spectrometric applications to perform laser ablation-desorption and ionization; however, the use of visible light is not very common. Here, we report a commercially…
Direct CO2 Activation and Conversion to Ethanol via Reactive Oxygen Species
Angewandte Chemie - International Edition
Abstract: The growing demand for energy and the excessive use of fossil fuels represents one of the main challenges for humanity. Storing solar energy in the form of chemical bonds to generate solar fuels or…
Headspace Injection Method for Intermittent Sampling and Profiling Analyses of Volatile Organic Compounds Using Dielectric Barrier Discharge Ionization (DBDI)
Journal of the American Society for Mass Spectrometry
Abstract: A direct headspace injection method is presented and optimized for the analysis of volatile organic compounds (VOCs) using dielectric barrier discharge ionization-mass spectrometry (DBDI-MS),…
Direct CO2 Activation and Conversion to Ethanol via Reactive Oxygen Species
Angewandte Chemie International Edition in English
Abstract: The growing demand for energy and the excessive use of fossil fuels represents one of the main challenges for humanity. Storing solar energy in the form of chemical bonds to generate solar fuels or…
Universal, untargeted detection of bacteria in tissues using metabolomics workflows
Nature Communications
Abstract: Fast and reliable identification of bacteria directly in clinical samples is a critical factor in clinical microbiological diagnostics. Current approaches require time-consuming bacterial isolation…
A Small Molecule Drug-Based Ru(II) Polypyridine Mass-Tag for Multimodal Imaging of Tissue Samples
ACS Central Science
Abstract: Mass spectrometry imaging (MSI) is a powerful tool for spatially resolved multiomics analysis of tissue samples in clinical research. However, its proteomics application is still limited due to…
UPLC-ESI-TOF-MS Profiling of Metabolome Alterations in Barley (Hordeum vulgare L.) Leaves Induced by Bipolaris sorokiniana
Journal of agricultural and food chemistry
Abstract: Spot blotch of barley (Hordeum vulgare L.), caused by Bipolaris sorokiniana, is responsible for major losses in crop yield. Breeding-resistant barley varieties have proven to be an effective…
A Golden Touch in the Design of Multifunctional Porphyrin Metallacages
CCS Chemistry
Abstract: The use of three-dimensional self-assembled metallacages (MCgs) as multimodal drug platforms holds great promise. However, the synthesis of MCgs with increased complexity and functionality is a great…
Wintersemester 2025/26
Sommersemester 2026
| Titel | Termine | Dauer | Art | Vortragende/r (Mitwirkende/r) |
|---|---|---|---|---|
| Analytische Chemie (CH0107) |
|
2 | VO | |
| Bildgebende Massenspektrometrie: Grundlagen und Praktikum |
|
3 | VI | |
| Forschungspraktikum Analytische Chemie (NAT0172) |
|
12 | FO | |
| Forschungspraktikum Analytische Chemie 2 (NAT0152) |
|
12 | FO | |
| Moderne Massenspektrometrie: Instrumente und Anwendungen (CH3127) |
|
3 | VI | |
| Seminar zu aktuellen Themen der in-situ Massenspektrometrie |
|
2 | SE |