Technische Universität München
Lehrstuhl für Biochemie (Prof. Groll)
Ernst-Otto-Fischer-Str. 8
85748 Garching b. München
Our research focuses on the study of enzymes, their ligands and reaction mechanisms by combining biological, chemical and analytical methods. In particular, we are interested in the functional and structural characterization of protein-protein and protein-ligand interactions, as well as in the development and practical application of biologically active compounds.
The multi-disciplinary approach of our projects includes techniques such as molecular biology, protein chemistry and crystallization, diffraction data collection and evaluation, model building and refinement, structure guided ligand design, chemical synthesis, as well as evaluation of protein-ligand interactions.
Journal of Medicinal Chemistry
Abstract: The proteasome inhibitors bortezomib, carfilzomib, and ixazomib all act by inhibiting multiple active sites of both constitutive proteasomes and immunoproteasomes. These clinical anticancer drugs are…
Structure
Abstract: Incorporating metal cofactors into computationally designed protein scaffolds provides a versatile route to novel protein functions, including the potential for new-to-nature enzyme catalysis.…
Chem
Abstract: Closthioamide (CTA) is a potent antibiotic with a unique polythioamide scaffold produced by Ruminiclostridium cellulolyticum . Unlike classical non-ribosomal peptide synthetases (NRPSs), which use…
Angewandte Chemie - International Edition
Abstract: Non-canonical methylation events generate terpene structures that evade classical biosynthetic predictions, as exemplified by the proposed C16 terpene hegelenether. Here, we show that this natural…
ACS Catalysis
Abstract: The design of artificial photoenzymes by incorporating synthetic chromophores into proteins represents a promising strategy to achieve non-natural biocatalytic transformations with high levels of…
Nature Microbiology
Abstract: Metronidazole is a front-line drug for the treatment of Helicobacter pylori infections. However, its mode of action and cellular targets are poorly defined, and higher dosing and combination therapies…
Chem
Abstract: Terpene synthases usually generate carbocations by either pyrophosphate (PP) elimination (class I) or substrate protonation (class II) to initiate cyclization cascades. By contrast, recent discoveries…
Chemical Science
Abstract: De novo designed metalloenzymes and photoenzymes are a valuable addition to the biocatalytic toolbox. We previously introduced PhotoLanZymes (PLZ), a family of lanthanide-dependent photoredox enzymes…
Journal of the American Chemical Society
Abstract: Terpene synthases produce a remarkable structural diversity from acyclic precursors through complex carbocation cascades. Here, we report the crystal structure of the bacterial sesterterpene synthase…
RSC Medicinal Chemistry
Abstract: Human sirtuin 2 (SIRT2) is an NAD+ dependant enzyme that has been linked to the pathogenesis of various diseases, making it a promising target for pharmaceutical intervention. This study presents a…
| Titel | Termine | Dauer | Art | Vortragende/r (Mitwirkende/r) |
|---|---|---|---|---|
| Arbeitskreisseminar - Prof. Groll |
|
1 | SE | |
| Bioanorganische Chemie (CH0648/CH0953) |
|
2 | VO | |
| Biochemie 3: Biologische Makromoleküle - Struktur und Funktion (CH0950/NAT0013) |
|
2 | VO | |
| Biochemisches Praktikum (CH4121) |
|
6 | PR | |
| Forschungspraktikum Biochemie 1 (CH0554) |
|
16 | FO | |
| Forschungspraktikum Biochemie 2 (CH0555) |
|
12 | FO | |
| Forschungspraktikum für Studierende der Biochemie (CH0943) |
|
8 | FO | |
| Spezielle Aspekte der Biochemie |
|
7 | MT |