Prof. Hendrik Dietz

H4K16 acylations destabilize chromatin architecture and facilitate transcriptional response during metabolic perturbations

Molecular Cell

Abstract: Histone modifications play crucial roles in genome function. However, how chromatin integrates physiological and metabolic responses at the molecular level remains largely unknown. Acetylation of…

Photothermally Powered 3D Microgels Mechanically Regulate Mesenchymal Stem Cells Under Anisotropic Force

Advanced Materials

Abstract: Exogenous forces significantly influence mammalian cell behavior, yet current strategies fail to resolve signaling processes between individual cells under conditions that accurately mimic the native…

Bio Meets Nano

International Journal of Molecular Sciences

Abstract: When iron oxide nanoparticles are incubated together with a biological broth, the biomolecules compete for the binding sites at the solid–liquid interface. At the same time, the biomass rearranges in…

Laser-Induced Metal-Organic Framework-Derived Flexible Electrodes for Electrochemical Sensing

ACS Applied Materials and Interfaces

Abstract: The successful development of a metal-organic framework (MOF)-derived Co/Co₃O₄/C core-shell composite integrated into laser-induced graphitic (LIG) carbon electrodes for electrochemical sensing is…

Nanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning

Nature Biotechnology

Abstract: Efficient and accurate nanocarrier development for targeted drug delivery is hindered by a lack of methods to analyze its cell-level biodistribution across whole organisms. Here we present Single Cell…

Programmable DNA shell scaffolds for directional membrane budding

Nature Communications

Abstract: In the pursuit of replicating biological processes at the nanoscale, controlling cellular membrane dynamics has emerged as a key area of interest. Here, we report a system mimicking virus assembly to…

Biophysics in the Cell

Abstract: This textbook is for all students of the natural sciences who want to understand and apply physical concepts to better describe fundamental cellular processes. For example, the phenomena of diffusion…

Hepatitis B Virus Neutralization with DNA Origami Nanoshells

ACS Applied Materials and Interfaces

Abstract: We demonstrate the use of DNA origami to create virus-trapping nanoshells that efficiently neutralize hepatitis B virus (HBV) in cell culture. By modification of the shells with a synthetic monoclonal…

Hierarchical assembly is more robust than egalitarian assembly in synthetic capsids

Proceedings of the National Academy of Sciences of the United States of America

Abstract: Self-assembly of complex and functional materials remains a grand challenge in soft material science. Efficient assembly depends on a delicate balance between thermodynamic and kinetic effects,…

Sensor macrophages derived from human induced pluripotent stem cells to assess pyrogenic contaminations in parenteral drugs

Biofabrication

Abstract: Ensuring the safety of parenteral drugs before injection into patients is of utmost importance. New regulations around the globe and the need to refrain from using animals however, have highlighted…