Glues that can STING
Molecular Cell
Abstract: Phosphoinositides regulate cellular signaling. Tan et al. 1 and Li et al. 2 identify PtdIns(3,5)P₂ and cholesterol as key lipids that stabilize STING oligomers and enable TBK1 activation, explaining…
Prof. Carina Baer de Oliveira Mann
Prof. Dr. rer. nat. Carina Baer de Oliveira Mann
Technische Universität München
Professur für Biomolekulare Kryo-Elektronenmikroskopie (Prof. Baer de Oliveira Mann)
Postadresse
Ernst-Otto-Fischer-Str. 8
85748 Garching b. München
- Tel.: +49 89 289 51690
- Raum: 5415.01.008
- Homepage
- E-Mail: carina.mann@tum.de
Research
Prof. de Oliveira Mann untersucht, wie sich unser Immunsystem und seine Rezeptoren zwischen selbst und fremd unterscheiden. Hierbei konzentriert sie sich auf Nucleotidyltransferasen (NTasen). Trotz ihrer Bedeutung für biologische Prozesse, die von der Immunität bis hin zur Entwicklung reichen, sind mehrere menschliche NTasen und ihre Produkte noch uncharakterisiert. Ziel ihrer Gruppe ist es, die molekulare Funktion dieser NTasen aufzudecken und neue nukleotidbasierte sekundäre Botenstoffe zu entdecken.
22 Publikationen
Structural basis for OAS2 regulation and its antiviral function
Molecular Cell
Abstract: Oligoadenylate synthetase (OAS) proteins are immune sensors for double-stranded RNA and are critical for restricting viruses. OAS2 comprises two OAS domains, only one of which can synthesize…
How enzyme-centered approaches are advancing research on cyclic oligo-nucleotides
FEBS Letters
Abstract: Cyclic nucleotides are the most diversified category of second messengers and are found in all organisms modulating diverse pathways. While cAMP and cGMP have been studied over 50 years, cyclic…
UNC93B1 variants underlie TLR7-dependent autoimmunity
Science Immunology
Abstract: UNC93B1 is critical for trafficking and function of nucleic acid–sensing Toll-like receptors (TLRs) TLR3, TLR7, TLR8, and TLR9, which are essential for antiviral immunity. Overactive TLR7 signaling…
ARF1 prevents aberrant type I interferon induction by regulating STING activation and recycling
Nature Communications
Abstract: Type I interferon (IFN) signalling is tightly controlled. Upon recognition of DNA by cyclic GMP-AMP synthase (cGAS), stimulator of interferon genes (STING) translocates along the endoplasmic reticulum…
cGLRs are a diverse family of pattern recognition receptors in innate immunity
Cell
Abstract: Cyclic GMP-AMP synthase (cGAS) is an enzyme in human cells that controls an immune response to cytosolic DNA. Upon binding DNA, cGAS synthesizes a nucleotide signal 2′3′-cGAMP that activates…
Monocyte-derived macrophages aggravate pulmonary vasculitis via cGAS/STING/IFN-mediated nucleic acid sensing
Journal of Experimental Medicine
Abstract: Autoimmune vasculitis is a group of life-threatening diseases, whose underlying pathogenic mechanisms are incompletely understood, hampering development of targeted therapies. Here, we demonstrate…
FoxP3 forkhead dimer
Immunity
Abstract: FoxP3 is critical for regulatory T cell function and, thus, overall immune homeostasis. In this issue of Immunity, Leng et al. reveal how FoxP3 achieves specific recognition of DNA and functional…
Phosphorylation of muramyl peptides by NAGK is required for NOD2 activation
Nature
Abstract: Bacterial cell wall components provide various unique molecular structures that are detected by pattern recognition receptors (PRRs) of the innate immune system as non-self. Most bacterial species…
Nuclear cGAS
EMBO Journal
Abstract: cGAS, an innate immune sensor of cellular stress, recognizes double-stranded DNA mislocalized in the cytosol upon infection, mitochondrial stress, DNA damage, or malignancy. Early models suggested…
Wintersemester 2025/26
| Titel | Termine | Dauer | Art | Vortragende/r (Mitwirkende/r) |
|---|---|---|---|---|
| Aktuelle Themen in der Biomolekularen Kryo Elektronenmikroskopie |
|
2 | SE | |
| Physikalische Biochemie, Praktikum (CH0410a) |
|
3 | PR | |
| Physikalische Biochemie, Vortragsseminar (CH0410b) |
|
2 | SE | |
| Rezeption wissenschaftlicher Literatur (CH5041) |
|
5 | SE | |
| Spezielle Aspekte der Biochemie |
|
7 | MT |
Sommersemester 2026
| Titel | Termine | Dauer | Art | Vortragende/r (Mitwirkende/r) |
|---|---|---|---|---|
| Spezielle Aspekte der Biochemie |
|
7 | MT | |
| Zelluläre Biochemie 1 (CH0663) |
|
3 | VI |