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Technical University of Munich
Technical University of Munich

PD Dr. Johannes Notni

Johannes Notni studied chemistry at the Friedrich-Schiller-Universität in Jena. During his diploma and PhD thesis at the Institute for Organic Chemistry and Macromolecular Chemistry, he focused on the mode of action of zinc enzymes and obtained a doctor's degree for a thesis about "Zinc thiolate and hydrosulfide complexes as versatile enzyme models". In 2007 and 2008, he went to the Group of Coordination and Bioinorganic Chemistry at Charles University in Prague, funded by a postdoc grant from the German Academic Exchange Service (DAAD), where he initiated a research programme on innovative 68GaIII-chelators for application in positron emission tomography. In 2009, he continued these activities at TUM and expanded his research interests to radiometal complexes for nuclear imaging and therapy, MRI contrast agents, as well as preclinical evaluation and clinical translation of innovative radiopharmaceuticals. He teaches at the radiopharmacy and inorganic chemistry departments and finished habilitation in 2015.

For his research, he received several awards, among them the "Radiopharmaceutical Council Young Investigator Award, 1st Prize" of the Society of Nuclear Medicine (2011) and the Innovation Prize in Medicinal and Pharmaceutical Chemistry awarded by the Gesellschaft Deutscher Chemiker (GdCh) and Deutsche Pharmazeutische Gesellschaft (DPhG) (2013). In 2016, he received the EANM Springer Prize for the most cited paper in EJNMMI Research, and in 2017, the Georg von Hevesy Prize from the Deutsche Gesellschaft für Nuklearmedizin (DGN).

Johannes Notni is leader of the research project A10, "Targeting α5β1 integrin for imaging of tumor angiogenesis and antiangiogenic therapy", in the framework of the Collaborative Research Centre 824, "Imaging for Selection, Monitoring and Individualization of Cancer Therapies".

During his 15-year teaching career, he has held lab courses, seminars, and lectures in basic organic and inorganic chemistry, radiochemistry, and radiopharmacy, and supervised lab courses in inorganic and analytical chemistry at TUM. Currently, he regularly teaches radiopharmacy at the TUM faculties of medicine and chemistry.

Publications

  • E. Farkas, A. Vágner, R. Negri, L. Lattuada, I. Tóth, V. Colombo, D. Esteban-Gómez, C. Platas-Iglesias, J. Notni*, Z. Baranyai*, G. B. Giovenzana*. PIDAZTA: Structurally Constrained Chelators for Efficient Formation of Stable Gallium-68 Complexes at Physiological pH. Chem. Eur. J. 2019, 25, accepted.

  • J. Notni*, H.-J. Wester. 68Ga-Radiopharmaka: Methode oder Episode? Radiopraxis 2019, 12, E31–E42.

  • F. Reichart, O. V. Maltsev, T. G. Kapp, A. F. B. Räder, M. Weinmüller, U. K. Marelli, J. Notni, A. Wurzer, R. Beck, H.-J. Wester, K. Steiger, S. Di Maro, F. Saverio Di Leva, L. Marinelli, M. Nieberler, U. Reuning, M. Schwaiger, H. Kessler*. Selective Targeting of Integrin αvβ8 by a Highly Active Cyclic Peptide. J. Med. Chem. 2019, 62, 2024–2037.

  • M. Schottelius*, A. Wurzer, K. Wissmiller, R. Beck, M. Koch, D. Gkorpas, J. Notni, T. Buckle, M. N. van Oosterom, K. Steiger, V. Ntziachristos, M. Schwaiger, F. W. B. van Leeuwen, H.-J. Wester. Synthesis and preclinical characterization of the PSMA-targeted hybrid probe PSMA-I&F for nuclear and fluorescence imaging of prostate cancer. J. Nucl. Med. 2019, 60, 71–78. Open Access—Free Download.

  • A. Wurzer, J. Pollmann, A. Schmidt, D. Reich, H.-J. Wester, J. Notni*. Molar Activity of Ga-68 Labeled PSMA Inhibitor Conjugates Determines PET Imaging Results. Mol. Pharmaceutics 2018, 15, 4296–4302.

  • J. Notni*, H.-J. Wester. 68Ga-Radiopharmaka: Methode oder Episode? Nuklearmediziner 2018, 41, 335–347.

  • J. Šimeček, P. Hermann, C. Seidl, F. Bruchertseifer, A. Morgenstern, H.-J. Wester, J. Notni*. Efficient formation of inert Bi-213 chelates by tetraphosphorus acid analogues of DOTA: Towards improved alpha-therapeutics. EJNMMI Res. 2018, 8, 78. Open Access—Free Download.

  • S. Procházková, V. Kubíček*, J. Kotek, A. Vágner, J. Notni, P. Hermann. Lanthanide(III) complexes of monophosphinate / monophosphonate DOTA-analogues: effects of the substituents on the formation rate and radiolabelling yield. Dalton Trans. 2018, 47, 13006–13015.

  • F. S. Di Leva, S. Tomassi, S. Di Maro, F. Reichart, J. Notni, A. Dangi, U. K. Marelli, D. Brancaccio, F. Merlino, H.-J. Wester, E. Novellino, H. Kessler, L. Marinelli*.  From a Helix to a Small Cycle: Metadynamics-Inspired αvβ6 Integrin Selective Ligands. Angew. Chem. Int. Ed. 2018, 57, 14645–14649; (EN) Angew. Chem. 2018, 130, 14856–14860. (DE)

  • A. Vágner, A. Forgács, E. Brücher, I. Tóth, A. Maiocchi, A. Wurzer, H.-J. Wester, J. Notni, Z. Baranyai*. Equilibrium thermodynamics, formation and dissociation kinetics of trivalent iron and gallium complexes of triazacyclononane-triphosphinate (TRAP) chelators: Unraveling the foundations of highly selective Ga-68 labeling. Front. Chem. 2018, 6, 170. Open Access—Free Download.

  • A. Wurzer, A. Vágner, D. Horváth, F. Fellegi, H.-J. Wester, F. K. Kálmán, J. Notni*. Synthesis of symmetrical tetrameric conjugates of the radiolanthanide chelator DOTPI for application in endoradiotherapy by means of click chemistry. Front. Chem. 2018, 6, 107. Open Access—Free Download.

  • T. G. Kapp, F. S. Di Leva, J. Notni, A. F. B. Räder, M. Fottner, D. Reich, A. Wurzer, K. Steiger, E. Novellino, U. K. Marelli, H-J. Wester, L. Marinelli, H. Kessler*. N-methylation of isoDGR Peptides: Discovery of a Selective α5β1-Integrin Antagonist as Potent Tumor Imaging Agent. J. Med. Chem. 2018, 61, 2490–2499.

  • S. F. Färber, A. Wurzer, F. Reichart, R. Beck, H. Kessler, H.-J. Wester, J. Notni*. Therapeutic Radiopharmaceuticals Targeting Integrin αvβ6. ACS Omega 2018, 3, 2428‒2436. Open Access—Free Download.

  • J. Notni*, H.-J. Wester. Re-thinking the role of radiometal isotopes: Towards a future concept for theranostic radiopharmaceuticals. J. Label. Compd. Radiopharm. 2018, 61, 141–153.

  • A. Wurzer, C. Seidl, A. Morgenstern, F. Bruchertseifer, M. Schwaiger, H.-J. Wester, J. Notni*. Dual-Nuclide Radiopharmaceuticals for Positron Emission Tomography Based Dosimetry in Radiotherapy. Chem. Eur. J. 2018, 24, 547‒550. Open Access—Free Download. View Cover Feature

  • A. Wacker, F. Carniato, C. Platas-Iglesias, D. Esteban-Gomez, H.-J. Wester, L. Tei*, J. Notni*. Dimer Formation of GdDO3A-Arylsulfonamide Complexes Causes Loss of pH-Dependency of Relaxivity. Dalton Trans. 2017, 46, 16828‒16836.

  • M. Nieberler*, U. Reuning, F. Reichart, J. Notni, H.-J. Wester, M. Schwaiger, M. Weinmüller, A. Räder, K. Steiger, H. Kessler*. Exploring the Role of RGD-Recognizing Integrins in Cancer. Cancers 2017, 9, 116. Open Access—Free Download.

  • K. Steiger, A.-M. Schlitter, W. Weichert, I. Esposito, H.-J. Wester, J. Notni*. Perspective of αvβ6-Integrin Imaging for Clinical Management of Pancreatic Carcinoma and Its Precursor Lesions. Mol. Imaging 2017, 16, doi: 10.1177/1536012117709384. Open Access—Free Download.

  • S. Maschauer*, J. Einsiedel, D. Reich, H. Hübner, P. Gmeiner, H.-J. Wester, O. Prante, J. Notni. Theranostic Value of Multimers: Lessons Learned from Trimerization of Neurotensin Receptor Ligands and Other Targeting Vectors. Pharmaceuticals 2017, 10, 29. Open Access—Free Download.

  • D. Reich, A. Wurzer, M. Wirtz, V. Stiegler, P. Spatz, J. Pollmann, H.-J. Wester, J. Notni*. Dendritic poly-chelator frameworks for multimeric bioconjugation. Chem. Commun. 2017, 53, 2586‒2589.

  • J. Notni*, D. Reich, O. V. Maltsev, T. G. Kapp, K. Steiger, F. Hoffmann, I. Esposito, W. Weichert, H. Kessler, H.-J. Wester. In-vivo PET Imaging of the Cancer Integrin αvβ6 Using 68Ga-Labeled Cyclic RGD Nonapeptides. J. Nucl. Med. 2017, 58, 671‒677.

    Georg von Hevesy-Preis by the DGN, 2017. Download Article

  • T. G. Kapp, F. Rechenmacher, S. Neubauer, O. V. Maltsev, A. E. Cavalcanti-Adam, R. Zarka, U. Reuning, J. Notni, H.-J. Wester, C. Mas-Moruno, J. Spatz, B. Geiger, H. Kessler*. A Comprehensive Evaluation of the Activity and Selectivity Profile of Ligands for RGD-binding Integrins. Sci. Rep. 2017, 7, 39805. Open Access—Free Download.

  • F. Hyafil*, J. Pelisek, I. Laitinen, M. Schottelius, M. Mohring, Y. Döring, E. P.C. van der Vorst, M. Kallmayer, K. Steiger, A. Poschenrieder, J. Notni, J. Fischer, C. Baumgartner, C. Rischpler, S. G. Nekolla, C. Weber, H.-H. Eckstein, H.-J. Wester, M. Schwaiger. Imaging the cytokine receptor CXCR4 in atherosclerotic plaques with the radiotracer 68Ga-pentixafor for positron emission tomography. J. Nucl. Med. 2017, 58, 499‒506.

  • J. Notni*, H.-J. Wester. A Practical Guide on the Synthesis of Metal Chelates for Molecular Imaging and Therapy by Means of Click Chemistry. Chem. Eur. J. 2016, 22, 11500‒11508.

  • J. Notni*, K. Steiger, F. Hoffmann, D. Reich, M. Schwaiger, H. Kessler, H.-J. Wester. Variation of Specific Activities of Ga-68-Aquibeprin and Ga-68-Avebetrin Enables Selective PET-Imaging of Different Expression Levels of Integrins α5β1 and αvβ3. J. Nucl. Med. 2016, 57, 1618‒1624. Download Article

  • J. Notni*, K. Steiger, F. Hoffmann, D. Reich, T. G. Kapp, F. Rechenmacher, S. Neubauer, H. Kessler, H.-J. Wester. Complementary, Selective PET-Imaging of Integrin Subtypes α5β1 and αvβ3 Using Ga-68-Aquibeprin and Ga-68-Avebetrin. J. Nucl. Med. 2016, 57, 460‒466. Download Article

  • C. D'Alessandria*, K. Pohle, F. Rechenmacher, S. Neubauer, J. Notni, H.-J. Wester, M. Schwaiger, H. Kessler, A. J. Beer. In vivo biokinetic and metabolic characterization of the 68Ga-labelled α5β1-selective peptidomimetic FR366. Eur. J. Nucl. Med. Mol. Imaging 2016, 43, 953‒963.

  • Z. Baranyai, D. Reich, A. Vágner, M. Weineisen, I. Tóth, H.-J. Wester, J. Notni*. A shortcut to high-affinity Ga-68 and Cu-64 radiopharmaceuticals: one-pot click chemistry trimerisation on the TRAP platform. Dalton Trans. 2015, 44, 11137‒11146. Open Access—Free Download.

  • G. Máté, J. Šimeček, M. Pniok, I. Kertész, J. Notni, H.-J. Wester, L. Galuska, P. Hermann*. The Influence of the Combination of Carboxylate and Phosphinate Pendant Arms in 1,4,7-Triazacyclononane-based Chelators on their 68Ga Labelling Properties. Molecules 2015, 20, 13112‒13126. Open Access—Free Download.

  • S. Poty, P. Désogère, J. Šimeček, C. Bernhard, V. Goncalves, C. Goze, F. Boschetti, J. Notni, H.-J. Wester, F. Denat*. MA-NOTMP: A Triazacyclononane Trimethylphosphinate Based Bifunctional Chelator for Gallium Radiolabelling of Biomolecules. ChemMedChem 2015, 10, 1475‒1479.

  • J. Notni*, J. Šimeček, H.-J. Wester. Phosphinic acid functionalized polyazacycloalkane chelators for radiodiagnostics and radiotherapeutics: unique characteristics and applications. ChemMedChem 2014, 9, 1107‒1115.

  • J. Šimeček, O. Zemek, P. Hermann, J. Notni*, H.-J. Wester. Tailored Gallium(III) Chelator NOPO: Synthesis, Characterization, Bioconjugation, and Application in Preclinical PET Imaging. Mol. Pharmaceutics 2014, 11, 3893‒3903.

  • J. Šimeček, J. Notni*, T. G. Kapp, H. Kessler, H.-J. Wester. Benefits of NOPO As Chelator in Gallium-68 Peptides, Exemplified by Preclinical Characterization of 68Ga-NOPO-c(RGDfK). Mol. Pharmaceutics 2014, 11, 1687‒1695.

  • J. Notni*, P. Hermann, I. Dregely, H.-J. Wester. Convenient Synthesis of Gallium-68 Labeled Gadolinium(III) complexes: Towards Bimodal Responsive Probes for Functional Imaging with PET/MRI. Chem. Eur. J. 2013, 19, 12602‒12606.

  • J. Šimeček, P. Hermann*, J. Havlíčková, E. Herdtweck, T. G. Kapp, N. Engelbogen, H. Kessler, H.-J. Wester, J. Notni*. A cyclen-based tetraphosphinate chelator for preparation of radiolabeled tetrameric bioconjugates. Chem. Eur. J. 2013, 19, 7748‒7757.

  • I. Laitinen*, J. Notni, K. Pohle, M. Rudelius, E. Farrell, S. G. Nekolla, G. Henriksen, S. Neubauer, H. Kessler, H.-J. Wester, M. Schwaiger. Comparison of cyclic RGD peptides for αvβ3 integrin detection in a rat model of myocardial infarction. EJNMMI Res. 2013, 3, 38. Open Access—Free Download. 

  • J. Šimeček, P. Hermann, H.-J. Wester, J. Notni*. How is 68Ga-labelling of macrocyclic chelators influenced by metal ion contaminants in 68Ge/68Ga generator eluates? ChemMedChem 2013, 8, 95‒103.

  • J. Notni*, K. Pohle, H.-J. Wester. Be spoilt for choice with radiolabelled RGD peptides: Preclinical evaluation of 68Ga-TRAP(RGD)3. Nucl. Med. Biol. 2013, 40, 33‒41.

  • J. Šimeček, H.-J. Wester, J. Notni*. Copper-64 labelling of triazacyclononane-triphosphinate chelators. Dalton Trans. 2012, 41, 13803‒13806.

  • J. Notni*, K. Pohle, H.-J. Wester. Comparative gallium-68 labeling of TRAP-, NOTA-, and DOTA-peptides: practical consequences for the future of gallium-68-PET. EJNMMI Res. 2012, 2, 28. Open Access—Free Download.

    EJNMMI Springer Prize 2016, MOST CITED PAPER in EJNMMI Research.

  • J. Šimeček, O. Zemek, P. Hermann, H.-J. Wester, J. Notni*. A monoreactive bifunctional triazacyclononane-phosphinate chelator with high selectivity for Gallium-68. ChemMedChem 2012, 7, 1375‒1378.

  • J. Notni. Mit Gallium-68 in ein neues Zeitalter? Nachr. Chem. 2012, 60, 645‒649.

  • J. Notni*, J. Plutnar, H.-J. Wester. Bone Seeking TRAP Conjugates: Surprising Observations and Implications on Development of Gallium-68-labeled Bisphosphonates. EJNMMI Res. 2012, 2, 13. Open Access—Free Download.

  • K. Pohle*, J. Notni, J. Bussemer, H. Kessler, M. Schwaiger, A. J. Beer. 68Ga-NODAGA-RGD is a suitable substitute for 18F-Galacto-RGD and can be produced with high specific activity in a cGMP compliant automated process. Nucl. Med. Biol. 2012, 39, 777‒784.

  • J. Šimeček, M. Schulz, J. Notni, J. Plutnar, V. Kubíček, J. Havlíčková, P. Hermann*. Complexation of Metal Ions with TRAP (1,4,7-Triazacyclononane-Phosphinic Acid) Ligands and 1,4,7-Triazacyclononane-1,4,7-triacetic Acid: Phosphinate-Containing Ligands as Unique Chelators for Trivalent Gallium. Inorg. Chem. 2012, 51, 577‒590.

  • J. Notni*, J. Šimeček, P. Hermann, H.-J. Wester. TRAP, a Powerful and Versatile Framework for Gallium-68 Radiopharmaceuticals. Chem. Eur. J. 2011, 17, 14718‒14722.

  • A. Al-Ibraheem, R. A. Bundschuh*, J. Notni, A. Buck, A. Winter, H.-J. Wester, M. Schwaiger, K. Scheidhauer. Focal uptake of 68Ga-DOTATOC in the pancreas: pathological or physiological correlate in patients with neuroendocrine tumours? Eur. J. Nucl. Med. Mol. Imaging 2011, 38, 2005‒2013.

  • J. Notni*, P. Hermann*, J. Havlíčková, J. Kotek, V. Kubíček, J. Plutnar, N. Loktionova, P. J. Riss, F. Rösch, I. Lukeš. A triazacyclononane-based bifunctional phosphinate ligand for the preparation of multimeric 68Ga tracers for positron emission tomography. Chem. Eur. J. 2010, 16, 7174‒7185.

  • J. Notni*, K. Pohle, J. A. Peters, H. Görls, C. Platas-Iglesias. Structural Study of Ga(III), In(III), and Fe(III) Complexes of Triaza-Macrocycle Based Ligands with N3S3 Donor Set. Inorg. Chem. 2009, 48, 3257‒3267.

  • J. Notni, S. Schenk, H. Görls, H. Breitzke, E. Anders*. Formation of a Unique Zinc Carbamate by CO2 Fixation: Implications for the Reactivity of Tetra-Azamacrocycle Ligated Zn(II) Complexes. Inorg. Chem. 2008, 47, 1382‒1390.

  • H. Görls, J. Notni, E. Anders*. [(1-Azulenyl)methanethiolato-κS](1,4,8,12-tetraazacyclopentadecane-κ4N)zinc(II) perchlorate. Acta Crystallogr., Sect. E: Struct. Rep. Online 2008, 64, m203.

  • J. Notni, S. Schenk, G. Protoschill-Krebs, J. Kesselmeier, E. Anders*. The Missing Link in COS Metabolism: A Model Study on the Reactivation of Carbonic Anhydrase from its Hydrosulfide Analogue. ChemBioChem 2007, 8, 530‒536.

  • J. Notni, W. Günther, E. Anders*. Zinc Thiolate Complexes [ZnLn(SR)]+ with Azamacrocyclic Ligands, Part III: The Influence of the Ligand Ln on the Reactivity of the Zinc-bound Thiolate. Eur. J. Inorg. Chem. 2007, 985‒993.

  • H. Görls, J. Notni, K. Kempe, E. Anders*. Diethyl 2,2'-(ethylenediimino)di(cyclopentenecarboxylate). Acta Crystallogr., Sect. E: Struct. Rep. Online 2007, 63, o4095.

  • H. Görls, J. Notni, E. Anders*. (Phenylmethanethiolato)(1,5,9-triazacyclododecane)zinc(II) thiocyanate. Acta Crystallogr., Sect. E: Struct. Rep. Online 2007, 63, m2556.

  • H. Görls, W. Günther, J. Notni, E. Anders*. p-Methylbenzenethiolato)[tris(3-phenyl-5-methylpyrazolyl)borato]zinc(II). Acta Crystallogr., Sect. E: Struct. Rep. Online 2007, 63, m2545.

  • J. Notni, S. Schenk, A. Roth, W. Plass, H. Görls, U. Uhlemann, A. Walter, M. Schmitt, J. Popp, S. Chatzipapadopoulos, T. Emmler, H. Breitzke, J. Leppert, G. Buntkowsky, K. Kempe, E. Anders*. Zinc Thiolate Complexes [ZnLn(SR)]+ with Azamacrocyclic Ligands, Part II: Mechanism of the Reaction with CS2. Eur. J. Inorg. Chem. 2006, 2783‒2791.

  • J. Notni, H. Görls, E. Anders*. Zinc Thiolate Complexes [ZnLn(SR)]+ with Azamacrocyclic Ligands: Synthesis and Structural Properties. Eur. J. Inorg. Chem. 2006, 1444‒1455.

  • S. Schenk, J. Notni, U. Köhn, K. Wermann, E. Anders*. Carbon Dioxide and related heterocumulenes at zinc and lithium cations: Bioinspired reactions and principles. Dalton Trans. 2006, 4191‒4206.

  • U. Uhlemann, M. Schmitt, K.-L. Oehme, J. Notni, E. Anders, J. Popp*. Introduction of a high pressure cell for use with Raman microscopy. J. Raman Spectrosc. 2006, 37, 442‒446.

  • A. Berg, J. Notni, H. Dörfelt, U. Gräfe*. Acremonol and Acremodiol, New Fungal Bislactones. J. Antibiot. 2002, 55, 660‒663.

  • D. Berger, M. Erdmann, J. Notni, W. Imhof*. The influence of ligand variation on the crystal properties of (η4-azadiene)Fe(CO)3-n(PR3)n (n = 1,2; R = Cy, Ph, OMe). CrystEngComm 2000, 4.

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