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Technical University of Munich
Technical University of Munich

Dr. Behrooz H. Yousefi

Scientific Co-worker

Behrooz Yousefi studied chemistry at the universities of Tabris, Justus-Liebig  Universität Gießen und Teheran and obtained his Ph.D. in organic chemistry. He worked as lecturer at the Material and Energy Research Center in Karaj and was later appointed assistant professor at the university of medical sciences, Tabris. As an ÖAD-research fellow he developed new biologically active compounds, pharmaca and metabolites with combinatorial and microwave synthetic methods, at the university of Graz and later at the Technical University of Vienna.  He then moved to TU Darmstadt for the development of pharmaca for amyloid plaque imaging in collaboration with the Schering AG, Berlin. Since 2005 he is a researcher at TU Munich. His research focuses on multimodal small animal imaging and pharmaceutical radiochemistry for imaging of amyloid plaques, neuro-peptidic aggregates, opioid receptors, integrin receptors and cardial receptors.

Forschung

  • Entwicklung neuer Radiopharmaka für neurodegenerative Erkrankungen (NDD)
  • Glutamatcarboxypeptidase II, PSMA

Lehre

  • Vorlesung "Pharmazeutische Radiochemie I und II"
  • Ph.D. Vorlesung "Hands- On Course on Preclinical Imaging"

Publications

  • Ortner M, Kurz A, Alexopoulos P, Auer F, Diehl-Schmid J, Drzezga A, Förster S, Förstl H, Perneczky R, Sorg C, Yousefi BH, Grimmer T. Biol Psychiatry. 2014 Jan 31. pii: S0006-3223(14)00058-4.

  • Grimmer T, Goldhardt O, Guo LH, Yousefi BH, Förster S, Drzezga A, Sorg C, Alexopoulos P, Förstl H, Kurz A, Perneczky R. LRP-1 polymorphism is associated with global and regional amyloid load in Alzheimer's disease in humans in-vivo. Neuroimage Clin. 2014 Feb 5;4:411-6.

  • Gärtner F. C., Wiedemann T., Yousefi B. H., Lee M., Repokis I., Higuchi T., Nekolla S. G., Yu M., Robinson S., Schwaiger M., Pellegata N. S. Preclinical Evaluation of 18F-LMI1195 for In Vivo Imaging of Pheochromocytoma in the MENX Tumor Model. J. Nucl. Med. 2013, Oct 17. [Epub ahead of print].

  • Bahrami K., Khodaei M. M., Naali F., Yousefi, B. H. Synthesis of polysubstituted pyridines via reactions of chalcones and malononitrile in alcohols using Amberlite IRA-400 (OH-) Tetrahedron Lett. 2013, 54, 5293-5298.

  • Higuchi T., Yousefi B. H., Kaiser F., Gärtner F. Rischpler C. Reder S., Yu M., Robinson S., Schwaiger M., Nekolla S. Assessment of the 18F-Labeled PET Tracer LMI1195 for Imaging Norepinephrine Handling in Rat Hearts. J. Nucl. Med. 2013, 54, 1142-1146.

  • von Reutern B., Grünecker B., Yousefi B. H., Henriksen G., Czisch M., Drzezga A. Voxel-Based Analysis of Amyloid-Burden Measured with [11C]PiB PET in a Double Transgenic Mouse Model of Alzheimer's Disease.Mol. Imaging Biol. 2013 [Epub ahead of print]

  • S. Förster, B. H. Yousefi, H.-J. Wester, E. Klupp, A. Rominger, H. Förstl, A. Kurz, T. Grimmer, A. Drzezga. Quantitative longitudinal interrelationships between brain metabolism and amyloid deposition during a 2-year follow-up in patients with early Alzheimer's disease. Eur J Nucl Med Mol Imaging DOI: 10.1007/s00259-012-2230-9.

  • B. H. Yousefi, A. Manook, B. von Reutern, M. Schwaiger, A. Drzezga, H.-J. Wester, G. Henriksen. Development of an improved radioiodinated 2-phenylimidazo[1,2-a]pyridine for non-invasive imaging of amyloid plaques. RSC Med. Chem. Commun. 2012, 3, 775-779.

  • Manook A., Yousefi B.H., Willuweit A, Platzer S, Reder S, Voss A, Huisman M, Settles M, Neff F, Velden J, Schoor M, von der Kammer H, Wester HJ, Schwaiger M, Henriksen G, Drzezga A. Small-Animal PET Imaging of Amyloid-Beta Plaques with [11C]PiB and Its Multi-Modal Validation in an APP/PS1 Mouse Model of Alzheimer's Disease. PLoS ONE 2012, 7, e31310

  • Grimmer T, Faust M, Auer F, Alexopoulos P, Förstl H, Henriksen G, Perneczky R, Sorg C, Yousefi B.H., Drzezga A, Kurz A. White matter hyperintensities predict amyloid increase in Alzheimer’s disease. Neurobiol. Aging 2012, 33, 2766-2773.

  • Grimmer T, Alexopoulos P, Tsolakidou A, Guo LH, Henriksen G, Yousefi B.H., Förstl H, Sorg C, Kurz A, Drzezga A, Perneczky R. Cerebrospinal fluid BACE1 activity and brain amyloid load in Alzheimer's disease. ScientificWorldJournal 2012, 2012, Article ID 712048.

  • Bahrami, K., Khodaei, M. M., Shakibaian V., Khaledian D., and Yousefi, B. H. TiCl4-promoted desulfurization of thiocarbonyls and oxidation of sulfides in the presence of H2O2. J. Sulfur Chem. 2012, 33, 155-163.
  • Förster S, Grimmer T, Miederer I, Henriksen G, Yousefi B. H. , Graner P, Wester HJ, Förstl H, Kurz A, Dickerson BC, Bartenstein P, Drzezga A. Regional Expansion of Hypometabolism in Alzheimer's Disease Follows Amyloid Deposition with Temporal Delay. Biol. Psychiatry 2012, 71, 792-797.
  • Yousefi B. H., Drzezga A., von Reutern B., Manook A., Schwaiger M., Wester H.J., Henriksen G. A Novel 18F-Labeled Imidazo[2,1-b]benzothiazole (IBT) for High-Contrast PET Imaging of β-Amyloid Plaques ACS Med. Chem. Lett. 2011, 2, 673–677.
  • Yousefi, B. H., Manook, A., Drzezga, A., von, R. B., Schwaiger, M., Wester, H.-J., Henriksen, G., Synthesis and Evaluation of 11C-Labeled Imidazo[2,1-b]benzothiazoles (IBTs) as PET Tracers for Imaging β-Amyloid Plaques in Alzheimer's Disease. J. Med. Chem. 2011, 54 (4), 949-956.

  • Jouyban A, Shayanfar A, Panahi-Azar V, Soleymani J, Yousefi B. H., Acree WE Jr, York P. Solubility prediction of drugs in mixed solvents using partial solubility parameters J Pharm Sci. 2011, 100:4368–4382.

  • Bahrami, K., Khodaei, M. M., Yousefi, B. H., Arabi, M. S., TMSCl-promoted selective oxidation of sulfides to sulfoxides with hydrogen peroxide. Tetrahedron Lett. 2010, 51 (52), 6939-6941.

  • Grimmer, T., Tholen, S., Yousefi, B. H., Alexopoulos, P., Forschler, A., Forstl, H., Henriksen, G., Klunk, W. E., Mathis, C. A., Perneczky, R., Sorg, C., Kurz, A., Drzezga, A., Progression of cerebral amyloid load is associated with the apolipoprotein E epsilon4 genotype in Alzheimer's disease. Biol Psychiatry 2010, 68 (10), 879-84.

  • Marton, J., Schoultz, B. W., Hjornevik, T., Drzezga, A., Yousefi, B. H., Wester, H. J., Willoch, F., Henriksen, G., Synthesis and evaluation of a full-agonist orvinol for PET-imaging of opioid receptors: [11C]PEO. J Med Chem 2009, 52 (18), 5586-9

  • Henriksen, G., Yousefi, B. H., Drzezga, A., Wester, H. J., Development and evaluation of compounds for imaging of beta-amyloid plaque by means of positron emission tomography. Eur J Nucl Med Mol Imaging 2008, 35 Suppl 1, S75-81

  • Abdollahi-Alibeik, M., Mohammadpoor-Baltork, I., Zaghaghi, Z., Yousefi, B. H. Efficient synthesis of 1,5-benzodiazepines catalyzed by silica supported 12-tungstophosphoric acid. Catal. Commun. 2008, 9 (15), 2496-2502.

  • Henriksen, G., Hauser, A. I., Westwell, A. D., Yousefi, B. H., Schwaiger, M., Drzezga, A., Wester, H. J., Metabolically stabilized benzothiazoles for imaging of amyloid plaques. J Med Chem. 2007, 50 (6), 1087-9.

  • Moghadam, M., Mohammadpoor-Baltork, I., Mirkhani, V., Tangestaninejad, S., Abdollahi-Alibeik, M., Yousefi, B. H., Kargar, H., Rapid and efficient synthesis of imidazolines and bisimidazolines under microwave and ultrasonic irradiation. Monatsh. Chem. 2007, 138 (6), 579-583.

  • Knesl, P., Yousefi, B. H., Mereiter, K., Jordis, U., Synthesis of (-)- and (+)-8-fluoro-galanthamine. Tetrahedron Lett. 2006, 47 (32), 5701-5703.

  • Yousefi, B. H., Jordis, U. Hexestrol bis[2-(diethylamino)ethyl] ether dihydrochloride. Molbank 2006, M511.

  • Gorobets, N. Y., Yousefi, B. H., Belaj, F., Kappe, C. O., Rapid microwave-assisted solution phase synthesis of substituted 2-pyridone libraries. Tetrahedron 2004, 60 (39), 8633-8644.

  • Stadler, A., Yousefi, B. H., Dallinger, D., Walla, P., Van, D. E. E., Kaval, N., Kappe, C. O. Scalability of Microwave-Assisted Organic Synthesis. From Single-Mode to Multimode Parallel Batch Reactors. Org. Process Res. Dev. 2003, 7 (5), 707-716.

  • Jouyban, A., Yousefi, B. H. A quantitative structure property relationship study of electrophoretic mobility of analytes in capillary zone electrophoresis. Comput. Biol. Chem. 2003, 27 (3), 297-303.

  • Fakhri, S. A., Yousefi, B. H. Efficient Synthesis and Theoretical Study of Siloxy-benzocyclooctenes: 7,8-Bis[(trimethylsilanyl)oxy]-5,6,9,10-tetrahydrobenzocyclo-octene and 6,9-Dimethyl-7,8-bis[(trimethylsilanyl)oxy]-5,6,9,10-tetrahydrobenzo-cyclooctene-6,9-dicarboxylic Acid Diethyl Ester. Tetrahedron 2000, 56 (42), 8301-8308.

  • Fakhri, S. A., Yousefi, B. H. Synthesis and characterization of 8-hydroxy-5,8,9,10-tetrahydro-6H-benzocycloocten-7-one, 5,6,9,10-tetrahydrobenzocyclooctene-7,8-dione and 6,7,10,11-tetrahydrobenzocycloocta[b]quinoxaline. Acta Chim. Slov. 2000, 47 (3), 317-326.

Patent

Henriksen G., Yousefi B. H., Wester H. J., Compounds for Non-Invasive Measurement of Aggregates of Amyloid Peptides PCT/EP2010/051704, DE112010000820 T5, Pending

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