Dipl. Chem. Karolin Pohle
Karolin Pohle studied chemistry at the Friedrich-Schiller-Universität in Jena. Her diploma thesis was concerned with "Synthesis, characterisation and metal complexation of 2',3'- and 3',5'-diaminonucleoside derivatives". As a Marie-Curie fellow she then worked in the Laboratory for Biocatalysis and Organic Chemistry of the University of Delft. There she developed Ga(III)-chelators for the application in positron emission tomography in the frame of the Marie-Curie project "Molecular Recognition for Diagnosis and Therapy". Since 2009 she is continuing her research at the TU Munich in the frame of her doctoral thesis.
- Y. Shen, M. Schottelius, K. Zelenka, M. De Simone, K. Pohle, H. Kessler, H.-J. Wester, P. Schmutz, R. Alberto. Orthogonally Protected Artificial Amino Acid as Tripod Ligand for Automated Peptide Synthesis and Labeling with [99mTc(OH2)3(CO)3]+. Bioconjugate Chem. 2013 24, 26–35.
- J. Notni, K. Pohle, H.-J. Wester. Be spoilt for choice with radiolabelled RGD peptides: Preclinical evaluation of 68Ga-TRAP(RGD)3. Nucl. Med. Biol. 2012, doi:10.1016/j.nucmedbio.2012.08.006.
J. Notni, K. Pohle, H.-J. Wester. Comparative gallium-68 labeling of TRAP-, NOTA-, and DOTA-peptides: practical consequences for the future of gallium-68-PET. EJNMMI Res. 2012, 2, 28.
K. Pohle*, J. Notni, J. Bussemer, H. Kessler, M. Schwaiger, A. J. Beer. 68Ga-NODAGA-RGD is a suitable substitute for 18F-Galacto-RGD and can be produced with high specific activity in a cGMP compliant automated process. Nucl. Med. Biol. 2012, 39, 777-784.
K. Pohle, J. Notni, J. Bussemer, M. Schwaiger, H.-J. Wester, H. Kessler, et al., Synthesis of [Ga-68]NODAGA-RGD using a fully automated module - labelling results and comparison of [Ga-68]NODAGA-RGD and [F-18]Galacto-RGD performance in in-vivo experiments, J. Labelled Comp. Radiopharm., 2011, 54, S229.
J. Notni, K. Pohle, J. a Peters, H. Görls, C. Platas-Iglesias, Structural study of Ga(III), In(III), and Fe(III) complexes of triaza-macrocycle based ligands with N3S3 donor set., Inorg. Chem. 2009,48, 3257-3267.
D. Koth, M. Gottschaldt, H. Görls, K. Pohle, The first salen-type ligands derived from 3’,5'-diamino-3',5'-dideoxythymidine and -dideoxyxylothymidine and their corresponding copper(II) complexes., Beilstein J. Org. Chem. 2006,2, 17.