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Technical University of Munich
Technical University of Munich

MSc. Jakub Šimeček

Scientific co-worker

Jakub Šimeček studied chemistry at Charles University in Prague. He obtained his bachelor degree with a work on "Synthesis and coordination properties of ethylenediamine-phosphinic- and phosphonic acids". This was followed by master studies at the Charles University. For his master degree he worked in the radiochemistry at the university in Helsinki on "New methods for fluorine-18 and carbon-11 labeling". In 2009 he started his doctoral work at the Charles University on the synthesis and coordination properties of triazacyclononane-phosphinates. Since 2011 he's continuing his research at TU München. In 2010 he was awarded the 1. prize for young scientists by the Czech and Slowakian Academy of Sciences.

Publications

  • J. Šimeček, O. Zemek, P. Hermann, J. Notni*, H.-J. Wester. The Tailored Gallium(III) Chelator NOPO: Synthesis, Characterization, Bioconjugation, and Application in Preclinical PET Imaging. Mol. Pharm. 2014, 11, doi:10.1021/mp400642s.

  • J. Šimeček, P. Hermann*, J. Havlíčková, E. Herdtweck, T. G. Kapp, N. Engelbogen, H. Kessler, H.-J. Wester, J. Notni*. A cyclen-based tetraphosphinate chelator for preparation of radiolabeled tetrameric bioconjugates. Chem. Eur. J. 2013, 19, 7748‒7757.

  • J. Šimeček, P. Hermann, H.-J. Wester, J. Notni*. How is 68Ga-labelling of macrocyclic chelators influenced by metal ion contaminants in 68Ge/68Ga generator eluates? ChemMedChem 2013, 8, 95‒103.

  • J. Šimeček, H.-J. Wester, J. Notni*. Copper-64 labelling of triazacyclononane-triphosphinate chelators. Dalton Trans. 2012, 41, 13803‒13806.

  • J. Šimeček, O. Zemek, P. Hermann, H.-J. Wester, J. Notni*. A monoreactive bifunctional triazacyclononane-phosphinate chelator with high selectivity for Gallium-68. ChemMedChem 2012, 7, 1375‒1378.

  • J. Šimeček, M. Schulz, J. Notni, J. Plutnar, V. Kubíček, J. Havlíčková, P. Hermann*. Complexation of Metal Ions with TRAP (1,4,7-Triazacyclononane-Phosphinic Acid) Ligands and 1,4,7-Triazacyclononane-1,4,7-triacetic Acid: Phosphinate-Containing Ligands as Unique Chelators for Trivalent Gallium. Inorg. Chem. 2012, 51, 577‒590.

  • J. Notni*, J. Šimeček, P. Hermann, H.-J. Wester. TRAP, a Powerful and Versatile Framework for Gallium-68 Radiopharmaceuticals. Chem. Eur. J. 2011, 17, 14718‒14722.

  • T. Koivula*, J. Šimeček, J. Jalomäki, K. Helariutta, A. J. Airaksinen. A comparative study on the effect of solvent on nucleophilic fluorination with [18F]fluoride: protic solvents as co-solvents in SN2 and SNAr reactions. Radiochim. Acta 2011, 99, 293‒300.

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