Technische Universität München
Professur für Proteinchemie (Prof. Zeymer)
Ernst-Otto-Fischer-Str. 8
85748 Garching b. München
Artificial Metalloenzymes and Photoenzymes
Our research focuses on the rational design and directed evolution of artificial metalloenzymes and photoenzymes. We aim to engineer novel biocatalysts and study their structure and molecular mechanism.
Enzymes are widely used as efficient, selective, and sustainable catalysts. However, the development of artificial enzymes for reactions that go beyond the nature’s synthetic repertoire remains a major challenge. We combine the versatility of transition metal catalysis and photocatalysis with the superb selectivity provided by proteins to generate novel enzymes. Catalyst optimization is done by directed evolution, a techniques that mimics natural selection in the laboratory.
ACS Catalysis
Abstract: The design of artificial photoenzymes by incorporating synthetic chromophores into proteins represents a promising strategy to achieve non-natural biocatalytic transformations with high levels of…
Chemical Science
Abstract: De novo designed metalloenzymes and photoenzymes are a valuable addition to the biocatalytic toolbox. We previously introduced PhotoLanZymes (PLZ), a family of lanthanide-dependent photoredox enzymes…
Structure
Abstract: In this meet-the-author Q&A, Structure's editor-in-chief, Karin Kühnel, speaks to Cathleen Zeymer from the Technical University of Munich about her research group's recent Structure paper entitled…
Structure
Abstract: Incorporating metal cofactors into computationally designed protein scaffolds provides a versatile route to novel protein functions, including the potential for new-to-nature enzyme catalysis.…
ACS Chemical Biology
Abstract: The specific incorporation of lanthanide ions is a promising strategy to equip biomolecules with a new function. Their long-lived luminescence, strong anomalous X-ray scattering, paramagnetism, Lewis…
Angewandte Chemie International Edition in English
Abstract: "The most important future application of my research would be the integration of designer enzymes into biocatalytic processes in industry… If I were a piece of lab equipment, I would be a plate…
Angewandte Chemie - International Edition
Abstract: Photoenzymatic catalysis facilitates stereoselective new-to-nature chemistry under mild conditions. In addition to the rational design of artificial photoenzymes, naturally occurring redox enzymes can…
Journal of the American Chemical Society
Abstract: Cerium photoredox catalysis has emerged as a powerful strategy to activate molecules under mild conditions. Radical intermediates are formed using visible light and simple complexes of the…
Faraday Discussions
Faraday Discussions
| Titel | Termine | Dauer | Art | Vortragende/r (Mitwirkende/r) |
|---|---|---|---|---|
| Biochemisches Grundpraktikum (CH0936) |
|
3 | PR | |
| Einführung in die Biochemie (CH0936) |
|
2 | VO | |
| Forschungspraktikum Biochemie 1 (CH0554) |
|
16 | FO | |
| Forschungspraktikum Biochemie 2 (CH0555) |
|
12 | FO | |
| Forschungspraktikum Molekularbiologie und Proteinbiologie (CH3182) |
|
16 | FO | |
| Forschungspraktikum Molekularbiologie und Proteinbiologie (CH5179) |
|
5 | PR | |
| Forschungspraktikum mit chemischem Schwerpunkt (CH0510) |
|
8 | FO | |
| Gruppenseminar der Professur für Proteinchemie |
|
2 | SE | |
| Rezeption wissenschaftlicher Literatur (CH5041) |
|
5 | SE | |
| Spezielle Aspekte der Biochemie |
|
7 | MT |
| Titel | Termine | Dauer | Art | Vortragende/r (Mitwirkende/r) |
|---|---|---|---|---|
| Forschungspraktikum Biochemie 1 (CH0554) |
|
16 | FO | |
| Forschungspraktikum Biochemie 2 (CH0555) |
|
12 | FO | |
| Forschungspraktikum mit chemischem Schwerpunkt (CH0510) |
|
8 | FO | |
| Gruppenseminar der Professur für Proteinchemie |
|
2 | SE | |
| Spezielle Aspekte der Biochemie |
|
7 | MT |