New Publication in Chemical Communication
Herein, we describe the total synthesis of the depsipeptide vioprolide B and of an analogue, in which the (E)-dehydrobutyrine amino acid was replaced by glycine. The compounds were studied in biological assays which revealed cytotoxicity solely for vioprolide B presumably by covalent binding to cysteine residues of elongation factor eEF1A1 and of chromatin assembly factor CHAF1A.
Reineke, N. O., Elsen, F. A. V., Grab, H. A., Mostert, D., Sieber, S. A., Bach, T. "Synthesis and biological evaluation of vioprolide B and its dehydrobutyrine-glycine analogue", Chem. Commun.
Link: https://doi.org/10.1039/D4CC02946A
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