Publications and Patents

Google Scholar profile of Stephan A. Sieber


Hu, Y., Mostert, D., Orgler, C., Andler, O., Zischka, H., Kazmaier, U., Vollmar, A. M., Braig, S., Sieber, S. A., Zahler, S. "Thermal proteome profiling reveals insight to antiproliferative and pro-apoptotic effects of Lagunamide A in the modulation of DNA damage repair", ChemBioChem, doi

Braun, J., Hu, Y., Jauch, A. T., Gronauer, T. F., Mergner, J., Bach, N.C., Traube, F. R., Zahler, S., Sieber, S. A. "Neocarzilin Inhibits Cancer Cell Proliferation via BST-2 Degradation, Resulting in Lipid Raft-Trapped EGFR", JACS Au, doi

Ruddell, S. A., Mostert, D., Sieber, S. A. "Target identification of usnic acid in bacterial and human cells", RSC Chem. Biol., doi

Boldini, D., Ballabio, D., Consonni, V., Todeschini, R., Grisoni, F., Sieber, S. A. "Effectiveness of molecular fingerprints for exploring the chemical space of natural products", J. Cheminform., doi

Boldini, D., Friedrich, L., Kuhn, D., Sieber, S. A. "Machine Learning Assisted Hit Prioritization for High Throughput Screening in Drug Discovery", ACS Cent. Sci., doi

Mostert, D., Bubeneck, W. A., Rauh, T., Kielkowski, P., Itzen, A., Jung, K., Sieber, S. A. "Pronucleotide Probes Reveal a Diverging Specificity for AMPylation vs UMPylation of Human and Bacterial Nucleotide Transferases", Biochemistry, doi

Braun, J., Ortega-Liebana, M. C., Unciti-Broceta, A., Sieber, S. A. "A Pd-labile fluoroquinolone prodrug efficiently prevents biofilm formation on coated surfaces", Org. Biomol. Chem., doi

Miller Naranjo, B.,  Zollo, M., Sieber, S. A., Lieleg, O. "Lubricity, wear prevention, and anti-biofouling properties of macromolecular coatings for endotracheal tubes", Biomater. Sci., doi

Schuh, M. G., Boldini, D., Sieber, S. A. "TWIN BOOSTER: Synergising Large Language Models with Barlow Twins and Gradient Boosting for Enhanced Molecular Property Prediction", arXiv, doi


Illigmann, A., Vielberg, M.-T., Lakemeyer, M., Wolf, F., Dema, T., Stange, P., Kuttenlochner, W., Liebhart, E., Kulik, A., Staudt, N., Malik, I., Grond, S., Sieber, S. A., Kaysser, L., Groll, M., Brötz-Oesterhelt, H. "Structure of Staphylococcus aureus ClpP Bound to the Covalent Active Site Inhibitor Cystargolide A", Angew. Chem. Int., doi

Weigert Muñoz, A., Zhao, W., Sieber, S. A. "Monitoring host-pathogen interactions using chemical proteomics", RSC Chem. Biol., doi

Höpfner, D., Cichy, A., Pogenberg, V., Krisp, C., Mezouar, S., Bach, N. C., Grotheer, J., Madariaga Zarza, S., Martinez, E., Bonazzi, M., Feige, M. J., Sieber, S. A., Schlüter, H., Itzen, A. "The DNA-binding induced (de)AMPylation activity of a Coxiella burnetii Fic enzyme targets Histone H3", Commun. Biol., doi

Boldini, D., Grisoni, F., Kuhn, D., Friedrich, L., Sieber, S. A. "Practical guidelines for the use of gradient
boosting for molecular property prediction", Journal of Cheminformatics, doi

Weigert-Muñoz, A., Meighen-Berger, K. M., Hacker, S. M., Feige, M. J., Sieber, S. A. "A chemical probe unravels the reactive proteome of health-associated catechols", Chem. Sci., doi

Fiedler, M. K., Drechsel, J., Schmidt, R. , Luppa, P. B., Bach,N .C., Sieber, S. A. "Rapid Diagnostic Platform for Personalized Vitamin B6 Detection in  Erythrocytes via PLP Cofactor Mimics", ACS Chem. Biol.; doi

Dienemann, J.-N., Chen, S.-Y., Hitzenberger, M.,Sievert, M. L., Hacker, S. M., Prigge, S. T., Zacharias, M. , Groll, M., Sieber, S. A. "A Chemical Proteomic Strategy Reveals Inhibitors of Lipoate Salvage in Bacteria and Parasites", Angew. Chem. Int., doi


Wilkinson, I., Castro-Falcon, G., Roda-Serrat, M., Purdy, T., Straetener, J., Broetz-Oesterhelt, H., Christensen, L., Sieber, S., Hughes, C. C., Maier, L., Brauny, L."The cyanobacterial “nutraceutical” phycocyanobilin inhibits cysteine protease legumain", ChemBioChem., doi

Wilkinson, I. V. L., Bottlinger, M., El Harraoui, Y., Sieber, S. A."Profiling the Heme-Binding Proteomes of Bacteria Using Chemical Proteomics", Angew. Chem. Int. Edit., doi

Boldini, D., Friedrich, L., Kuhn, D., Sieber. S. A. "Tuning gradient boosting for imbalanced bioassay modelling with custom loss functions", J. Cheminformatics, doi

Mideksa, Y. G., Aschenbrenner, I.,Fux, A., Kaylani, D., Weiß, C. A.M., Nguyen, T.-A., Bach, N. C., Lang, K., Sieber, S. A., Feige, M. J. "A comprehensive set of ER protein disulfide isomerase family members supports the biogenesis of pro-inflammatory interleukin 12 family cytokines", J. Biol. Chem., doi

Bloemeke, N., Meighen-Berger, K., Hitzenberger, M., Bach, N. C., Parr, M., Coelho, j. PL., Frishman, D., Zacharias, M., Sieber, S. A., Feige, M. J. "Intramembrane client recognition potentiates the chaperone functions of calnexin", EMBO J., doi

Reinhardt, T.*, Lee, K.M.*, Niederegger, L., Hess, C.R., Sieber, S.A. "Indolin-2-one nitroimidazole antibiotics exhibit an unexpected dual mode of action", ACS Chem. Biol., doi

Ranava, D., Scheidler, C.M., Pfanzelt, M., Fiedler, M., Sieber, S.A., Schneider, S., Yap, M.-N.F. "Bidirectional sequestration between a bacterial hibernation factor and a glutamate metabolizing protein", PNAS, doi

Reinhardt, L., Thomy, D., Lakemeyer, M., Westermann, L., Ortega, J., Sieber, S., Sass, P., Brötz-Oesterhelt, H., "Antibiotic acyldepsipeptides stimulate the Streptomyces Clp-ATPase/ClpP complex for accelerated proteolysis", mBio, doi

Morimoto, K., Krahn, D., Kaschani, F., Hopkinson-Woolley, D., Gee, A., Buscaill, P., Mohammed, S., Sieber, S.A., Cravatt, B., Schofield, C., van der Hoorn, R., "Broad-range metalloprotease profiling in plants uncovers immunity provided by defence-related metalloenzyme", New Phytol., doi

Wilkinson, I.V.L., Pfanzelt, M. Sieber, S.A.*, "Functionalised Cofactor Mimics for Interactome Discovery and Beyond", Angew. Chem. Int. Edit., doi

Weigert Muñoz, A., Hoyer, E., Schumacher, K., Grognot, M., Taute, K.M., Hacker, S.M.
Sieber, S.A.*, Jung, K.*, "Eukaryotic catecholamine hormones influence the chemotactic control of Vibrio
campbellii by binding to the coupling protein CheW", PNAS, doi

Pfanzelt, M., Maher, T.E., Absmeier, R.M., Schwarz, M., Sieber, S.A.*, "Tailored Pyridoxal Probes Unravel Novel Cofactor-Dependent Targets and Antibiotic Hits in Critical Bacterial Pathogens", Angew. Chem. Int. Edit., doi


Nguyen, T.-A., Gronauer, T.F., Nast-Kolb, T., Sieber, S.A.*, Lang, K.*, "Substrate profiling of caseinolytic protease P via a site-specificphotocrosslinking approach", Angew. Chem. Int. Edit., doi

Key, J., Torres-Odio, S., Bach, N.C., Gispert, S., Koepf, G., Reichlmeir, M., West, A.P., Prokisch, H., Freisinger, P., Newman, W.G., Shalev, S., Sieber, S.A., Wittig, I., Auburger G., "Inactivity of peptidase ClpP causes primary accumulation of mitochondrial disaggregase ClpX with its interactors at the nucleoid and RNA granule", Cells, doi

Arisetti, N., Fuchs, H.L.S., Coetzee, J., Orozco, M., Ruppelt, D., Bauer, A., Heimann, D., Kuhnert, E., Bhamidimarri, S.P., Bafna, J.A., Hinkelmann, B., Eckel, K., Sieber, S.A., Müller, P.P., Herrmann, J., Müller, R., Winterhalter, M., Steinem, C., Brönstrup, M., "Total Synthesis and Mechanism of Action of the Antibiotic Armeniaspirol A", Chem. Sci., doi

Kyrousi, C., O’Neill, A., Brazovskaja, Zhisong He, A., Kielkowski, P., Coquand, L., Di Giaimo, R., D’ Andrea, P., Belka, A., Forero Echeverry, A., Mei, D., Lenge, M., Cruceanu, C., Buchsbaum, I., Khattak, S., Fabien, G., Binder, E., Elmslie, F., Guerrini, R., Baffet, A., Sieber, S.A.,Treutlein, B., Robertson, S., and Cappello, S., "Extracellular LGALS3BP regulates neural progenitor position and relates to human cortical complexity", Nat. Commun., doi

Meßner, M., Mandl, M.M., Hackl, M.W., Reinhardt, T., Ardelt, A.A., Szczepanowska, K., Frädrich, J.E., Waschke, J., Jeremias, I., Fux, A., Stahl, M., Vollmar, A.M., Sieber, S.A., Pachmayr J., "Small molecule inhibitors of the mitochondrial ClpXP protease possess cytostatic potential and re-sensitize chemo-resistant cancers", Sci. Rep., doi

Wiechmann, S., Ruprecht, B., Siekmann, T., Zheng, R., Frejno, M., Kunold, E., Bajaj, T., Zolg, D.P., Sieber, S.A., Gassen, N.C., Kuster, B., "Chemical Phosphoproteomics Sheds New Light on the Targets and Modes of Action of AKT Inhibitors", ACS Chem. Biol., doi

Mayer, R.J., Allihn, P.W.A., Hampel, N., Mayer, P., Sieber, S.A., Ofial, A., "Electrophilic Reactivities of Cyclic Enones and α,β-Unsaturated Lactones", Chem. Sci., doi

Allihn, P.W A., Hackl, M.W., Ludwig, C., Hacker, S.M., Sieber, S.A., "A tailored phosphoaspartate probe unravels CprR as a response regulator in Pseudomonas aeruginosa interkingdom signaling", Chem. Sci., doi

Hübner, I., Shapiro, J.A., Hoßmann, J., Drechsel, J., Hacker, S.M., Rather, P.N., Pieper, D.H., Wuest, W.M., Sieber, S.A., "Broad spectrum antibiotic Xanthocillin X Effectively Kills Acinetobacter baumanii via dysregulation of heme biosynthesis", ACS Cent. Sci., doi

Schlagintweit, J.F., Jakob, C.H.G., Meigen-Berger, K., Gronauer, T.F., Weigert-Muñoz, A., Weiß, V., Feige, M., Sieber, S.A., Correia, J.D.G., Kühn, F.E., "Fluorescent palladium(II) and platinum(II) NHC/1,2,3-triazole complexes: antiproliferative activity and selectivity against cancer cells", Dalton Trans., doi


Jakob, C.H.G.*, Weigert-Muñoz, A.*, Schlagintweit, J.F.,Weiß, V., Reich, R.M., Sieber, S.A., Correia, J.D.G., Kühn, F.E., "Anticancer and antibacterial properties of trinuclear Cu(I), Ag(I) and Au(I) macrocyclic NHC/urea complexes", J. Organomet. Chem., doi

Rauh, T., Brameyer, S., Kielkowski, P., Jung, K., Sieber, S.A., "MS-based in situ proteomics reveals AMPylation of host proteins during bacterial infection", ACS Infect. Dis., doi

Hübner, I., Dienemann, J.-N., Friederich, J., Schneider, S., Sieber, S.A., "Tailored cofactor traps for the in situ detection of hemithioacetal-forming pyridoxal kinases", ACS Chem. Biol., doi

Kirsch, V., Fetzer, C., Sieber, S.A., "A global inventory of ClpP and ClpX regulated proteins in Staphylococcus aureus", J. Proteome Res., doi

Drechsel, J., Kyrousi, C., Cappello, S., Sieber, S.A., "Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping", RSC Chem. Biol., doi

Sieber, S. A., Cappello, S., Kielkowski, P., "From Young to Old:AMPylation Hits the Brain", Cell Chem. Biol., doi

Macsics, R., Hackl, M.W., Fetzer C., Mostert, D., Bender, J., Layer, F., Sieber, S.A., "Comparative Target Analysis of Chlorinated Biphenyl Antimicrobials Highlights MenG as Molecular Target of Triclocarban", Appl. Environ. Microbiol., doi

Pfab, M., Kielkowski, P., Krafczyk, R., Volkwein, W., Sieber, S.A., Lassak, J., Jung, K., "Synthetic post-translational modifications of elongation factor P using the ligase EpmA", The FEBS Journal, doi

Grab, H.A., Kirsch, V.C., Sieber, S.A., Bach, T., "Total Synthesis of the Cyclic Depsipeptide Vioprolide D via its (Z)-Diastereoisomer",
Angew. Chem. Int. Edit., doi

Buchsbaum, I.Y., Kielkowski, P., Giorgio, G., O'Neill, A.C., Di Giaimo, R., Kyrousi, C., Khattak, S., Sieber, S.A., Robertson, S.P., Cappello, S., "ECE2 regulates Neurogenesis and Neuronal Migration during Human Cortical Development",
EMBO Rep., doi

Pinheiro, B., Scheidler, C., Kielkowski, P., Schmid, M., Forné, I., Ye, S., Reiling, N., Takano, E., Imhof, A., Sieber, S.A., Schneider, S., Jung, K., "Structure and function of a novel elongation factor P subfamily in Actinobacteria",
Cell Rep., doi

Winkeljann, B., Bauer, M.G., Marczynski, M., Rauh, T., Sieber, S.A., Lieleg, O., "Covalent Mucin Coatings Form Stable Anti-Biofouling Layers on a Broad Range of Medical Polymer Materials",
Adv. Mater. Interfaces, doi

Lee, K.M., Le, P., Sieber, S.A.*, Hacker, S.M.*, "Degrasyn exhibits antibiotic activity against multi-resistant Staphylococcus aureus by modifying several essential cysteines",
Chem. Commun., doi


Mühlhofer, M., Berchtold, E., Stratil, C.G., Csaba, G., Kunold, E., Bach, N.C., Sieber, S.A., Haslbeck, M., Zimmer, R., Buchner, J., "The heat shock response in yeast maintains protein homeostasis by chaperoning and replenishing proteins",
Cell Rep., doi

Kielkowski, P., Buchsbaum, I.Y., Becker, T., Bach, K., Cappello, S., Sieber, S.A., "A pronucleotide probe for live cell imaging of protein AMPylation",
ChemBioChem, doi

Kielkowski, P.*, Buchsbaum, I.Y.*, Kirsch, V.C., Bach, N.C., Drukker, M, Cappello, S.*, Sieber, S.A.*, "FICD activity and AMPylation remodelling modulate human neurogenesis",
Nat. Commun., doi

Fux, A., Sieber, S.A., "Biochemical and proteomic studies of human pyridoxal 5’-phosphate-binding protein (PLPBP)",
ACS Chem. Biol., doi

Kirsch, V.C.*, Orgler, C.*, Braig, S., Jeremias, I., Auerbach, D., Müller, R., Vollmar, A.M.*, Sieber, S.A.*, "The cytotoxic natural product vioprolide A target nucleolar protein 14 essential for ribosome biogenesis",
Angew. Chem. Int. Edit., doi

Le, P.*, Kunold, E.*, Macsics, R.*, Rox, K., Jennings, M., Ugur, I., Reinecke, M., Chaves-Moreno, D., Hackl, M.W., Fetzer, C., Mandl, F.A.M., Lehmann, J., Korotkov, V.S., Hacker, S.M., Küster, B., Antes, I., Pieper, D., Rohde, M., Wuest, W.M., Medina, E., Sieber, S.A., " Repurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus, persisters and biofilms ",
Nat. Chem., doi

Eyermann, B., Meixner, M., Brötz-Oesterhelt, H., Antes, I., Sieber, S.A., "Acyldepsipeptide probes facilitate specific detection of caseinolytic protease P independent of its oligomeric and activity state",
ChemBioChem, doi

Fux, A., Pfanzelt, M., Kirsch, V.C., Hoegl, A., Sieber, S.A., "Customizing functionalized cofactor mimics to study the human pyridoxal 5’-phosphate-binding proteome",
Cell Chem. Biol., doi

Gatsogiannis, C.*, Balogh, D.*, Merino, F., Sieber, S.A.*, Raunser, S.*, "Cryo-EM structure of the ClpXP protein degradation machinery",
Nat. Struct. Mol. Biol., doi

Le, P., Nodwell, M., Eirich, J., Sieber, S.A., "A chemical proteomic analysis of illudin‐interacting proteins",
Chem. Eur. J., doi

Fetzer, C., Korotkov, V.S., Sieber, S.A., "Hydantoin analogs inhibit the fully assembled ClpXP protease without affecting the individual peptidase and chaperone domains",
Org. Biomol. Chem., doi

Gleissner, C.M.L., Pyka, C.L., Heydenreuter, W., Gronauer, T.F., Atzberger, C., Korotkov, V.S., Cheng, W., Hacker, S., Vollmar, A., Braig, S.*, Sieber, S.A.*, "Neocarzilin A is a potent inhibitor of cancer cell motility targeting VAT-1 controlled pathways",
ACS Cent. Sci., doi

Zhao, W., Cross, A.R., Crow-McAuliffe, C., Weigert-Munoz, A., Csatary, E.E., Solinski, A.E., Krysiak, J., Goldberg, J.B., Wilson, D.N., Medina, E., Wuest, W.M., Sieber, S.A., "The natural product elegaphenone potentiates antibiotic effects against Pseudomonas aeruginosa",
Angew. Chem. Int. Edit., doi

Winnacker, M., Beringer, A.J.G., Gronauer, T.F., Güngör, H.H., Reinschlüssel, L., Rieger, B., Sieber, S.A., "Polyamide/PEG Blends as Biocompatible Biomaterials for the Convenient Regulation of Cell Adhesion and Growth",
Macromol. Rapid Commun., doi

Crane, E.A., Heydenreuter, W., Beck, K.R., Strajhar, P., Vomacka, J., Smiesko, M., Mons, E., Barth, L., Neuburger, M., Vedani, A., Odermatt, A., Sieber, S.A., Gademann, K., "Profiling Withanolide A for Therapeutic Targets in Neurodegenerative Diseases",
Bioorg. Med. Chem., doi

Lakemeyer, M., Bertosin, E., Möller, F., Balogh, D., Strasser, R., Dietz, H., Sieber, S.A., "Tailored peptide phenyl esters block ClpXP proteolysis by an unusual breakdown into a heptamer-hexamer assembly",
Angew. Chem. Int. Edit., doi

De Ford, C., Penchalaiah, K., Kreft, A., Humar, M., Heydenreuter, W., Kangani, M., Sieber, S.A., Tietze, L.F., Merfort, I., "Bifunctional Duocarmycin Analogues as Inhibitors of Protein Tyrosine Kinases",
J. Nat. Prod., doi

Coelho, J., Stahl, M., Blömeke, N., Meighen-Berger, K., Alvira, C.P., Zhang, Z.R., Sieber, S.A., Feige, M., "A network of chaperones prevents and detects failures in membrane protein lipid bilayer integration",
Nat. Commun., doi


Falcón Garcia, C., Stangl, F., Götz, A., Zhao, W., Sieber, S.A., Opitz, M., Lieleg, O., "Topographical alterations render bacterial biofilms susceptible to chemical and mechanical stress",
Biomater. Sci., doi

Koczian, F., Nagło, O., Vomacka, J., Vick, B., Servatius, P., Zisis, T., Hettich, B., Kazmaier, U., Sieber, S.A., Jeremias, I., Zahler, S., Braig, S., "Targeting the ER-mitochondria interface sensitizes leukemia cells towards cytostatics",
Haematologica, doi

Vogele, K., Frank, T., Gasser, L., Goetzfried, M., Hackl. M.W., Sieber, S.A., Simmel, F., Pirzer, T., "Towards synthetic cells using peptide-based reaction compartments",
Nat. Commun., doi

Stahl, M., Korotkov, V.S., Balogh, D., Kick, L.M., Gersch, M., Pahl, A., Kielkowski, P., Richter, K., Schneider, S., Sieber, S.A., "Selective Activation of Human Caseinolytic Protease P (ClpP)",
Angew. Chem. Int. Edit., doi

Fux, A., Korotkov, V.S., Schneider, M., Antes, I., Sieber, S.A., "Chemical cross-linking enables drafting ClpXP proximity maps and taking snapshots of in situ interaction networks",
Cell Chem. Biol., doi

Hoegl, A., Nodwell, M.B., Kirsch, V.C., Bach, N.C., Pfanzelt, M., Stahl, M., Schneider, S., Sieber, S.A., "Mining the cellular inventory of pyridoxal phosphate-dependent enzymes with functionalized cofactor mimics",
Nat. Chem., doi

Gronauer, T.F., Mandl, M.M., Lakemeyer, M., Hackl, M.W., Meßner, M., Korotkov, V.S., Pachmayr, J., Sieber, S.A., "Design and synthesis of tailored human caseinolytic protease P inhibitors",
Chem. Commun., doi

Drechsel, J., Mandl, F.A., Sieber, S.A., "A chemical probe to monitor the parkinsonism-associated protein DJ-1 in live cells",
ACS Chem. Biol., doi

Lakemeyer, M., Zhao, W., Mandl, F.A., Hammann, P., Sieber, S.A., "Thinking outside the box - novel antibacterials to tackle the resistance crisis",
Angew. Chem. Int. Edit., doi

Giglio, K.M., Keohane, C.E., Stodghill, P.V., Steele, A.D., Fetzer, C., Sieber, S.A., Filiatrault, M.J., Wuest, W.M., "Transcriptomic profiling suggests that Promysalin alters metabolic flux, motility, and iron regulation in Pseudomonas putida KT2440",
ACS Infect. Dis., doi

Hofbauer, B.*, Vomacka, J.*, Stahl, M., Korotkov, V.S., Jennings, M., Wuest, W., Sieber, S.A., "A dual inhibitor of Staphylococcus aureus virulence and biofilm attenuates expression of major toxins and adhesins",
Biochemistry, doi

Keohane, C.E., Steele, A.D., Fetzer, C., Khowsathit, J., van Tyne, D., Moynié, L., Gilmore, M.S., Karanicolas, J., Sieber, S.A., Wuest, W.M., "Promysalin Elicits Species-Selective Inhibition of Pseudomonas aeruginosa by Targeting Succinate Dehydrogenase",
J. Am. Chem. Soc., doi


Wright, M.H., Tao, Y., Drechsel, J., Krysiak, J., Chamni, S., Weigert Muñoz, A., Harvey, N., Romo, D., Sieber, S.A., "Quantitative Chemoproteomic Profiling Reveals Multiple Target Interactions of Spongiolactone Derivatives in Leukemia Cells",
Chem. Commun., doi

Lehmann, J., Cheng, T.Y., Aggarwal, A., Park, A.S., Zeiler, E., Raju, R.M., Akopian, T., Kandror, O., Bach, N.C., Sacchettini, J.C., Moody, D.B., Rubin, E.J., Sieber, S.A., "An Antibacterial β-Lactone Kills Mycobacterium tuberculosis by Disrupting Mycolic Acid Biosynthesis",
Angew. Chem. Int. Edit., doi

Fetzer, C., Korotkov, V.S., Thänert, R., Lee, K.M., Neuenschwander, M., von Kries, J.P., Medina, E., Sieber, S.A., "A Chemical Disruptor of the ClpX Chaperone Complex Attenuates the Virulence of Multidrug-Resistant Staphylococcus aureus",
Angew. Chem. Int. Edit., doi

Stahl, M., Sieber, S.A., "An Amino Acid Domino Effect Orchestrates ClpP's Conformational States",
Curr. Opin. Chem. Biol.doi

Stiegler, S.C., Rübbelke, M., Korotkov, V.S., Weiwad, M., John, C., Fischer, G., Sieber, S.A., Sattler, M., Buchner, J., "A chemical compound inhibiting the Aha1-Hsp90 chaperone complex",
J. Biol. Chem.doi

Wright, M.H., Fetzer, C., Sieber, S.A., "Chemical probes unravel an antimicrobial defense response triggered by binding of the human opioid dynorphin to a bacterial sensor kinase",
J. Am. Chem. Soc., doi

Lieleg, O., Werb, M., Falcón García, C., Bach, N.C., Grumbein, S., Sieber, S.A., Opitz, M., "Surface topology affects wetting behavior of Bacillus subtilis biofilms", 
npj Biofilms Microbiomes, doi

Krysiak, J.*, Stahl, M.*, Vomacka, J.*, Fetzer, C., Lakemeyer, M., Fux, A., Sieber, S.A.*, "Quantitative map of beta-lactone induced virulence regulation", 
J. Proteome Res., doi

Rieb, J., Dominelli, B., Mayer, D., Jandl, C., Drechsel, J., Heydenreuter, W., Sieber, S.A., Kühn, F.E., "Influence of wing-tip substituents and reaction conditions on the structure, properties and cytotoxicity of Ag(I)– and Au(I)–bis(NHC) complexes",
Dalton Trans., doi

Zhu, M., Harshbarger, W., Robles, O., Krysiak, J., Hull, K., Cho, S.W., Richardson, R., Yang, Y., Garcia, A., Spiegelman, L., Ramirez, B., Wilson, C., Yau, J.A., Moore, J., Walker, C., Sacchettini, J., Liu, W., Sieber, S.A., Smith, J., and Romo, D.*, "A Strategy for Dual Inhibition of the Proteasome and Fatty Acid Synthase with Belactosin C-Orlistat Hybrids",
Bioorg. Med. Chem., doi

Rossetti, L.*, Kuntz, L.A.*, Kunold, E., Schock, J., Müller, K.W., Grabmayr, H., Stolberg-Stolberg, J., Pfeiffer, F., Sieber, S.A., Burgkart, R.*, Bausch, A.R.*, "The microstructure and micromechanics of the tendon-bone insertion", 
Nat. Mater., doi


Lehmann, J., Richers, J., Pöthig, A., Sieber, S.A.*, "Synthesis of Ramariolide Natural Products and Discovery of their Targets in Mycobacteria", 
Chem. Commun.doi

Balogh, D.*, Dahmen, M.*, Stahl, M., Poreba, M., Gersch, M., Drag, M., Sieber S.A.*, "Insights into ClpXP proteolysis: Heterooligomerization and partial deactivation enhance chaperone affinity and substrate turnover in Listeria monocytogenes", 
Chem. Sci., doi

Kleiner, P.*, Heydenreuter, W.*, Stahl, M.*, Korotkov, V.S., Sieber S.A.*, "A whole proteome inventory of background photocrosslinker binding", 
Angew. Chem. Int. Edit., doi

Kaiser, F., Schmidt, A., Heydenreuter, W., Altmann, P.J., Casini, A., Sieber S.A., Kühn, F.E., "Self-assembled Palladium and Platinum Coordination Cages: Photophysical Studies and Anticancer Activity", 
Eur. J. Inorg. Chem. doi

Mandl, F.A.*, Kirsch, V.C.*, Ugur, I., Kunold, E., Vomacka, J., Fetzer, C., Schneider, S., Richter, K., Fuchs, T.M., Antes, I., Sieber S.A.*, "Natural product inspired amino-epoxybenzoquinones kill members of the gram-negative pathogen Salmonella by attenuating cellular stress response", 
Angew. Chem. Int. Edit. doi

Krysiak, J., and Sieber, S.A., "Activity-Based Protein Profiling in Bacteria", 
Meth. Mol. Bio. doi

Zhao, W., Lorenz, N., Jung, K., and Sieber, S.A., "Mechanistic analysis of aliphatic β-lactones in Vibrio harveyi reveals a quorum sensing independent mode of action", 
Chem. Commun. doi

Bolz, C., Bach, N.C., Meyer, H., Müller, G., Dawidowski, M., Popowicz, G., Sieber, S.A., Skerra, A., Gerhard, M., "Comparison of enzymatic properties and small molecule inhibition of ɣ–glutamyltranspeptidases from pathogenic and commensal bacteria", 
Biol. Chem. doi

Javaheri, A., Kruse, T., Moonens, K., Mejías-Luque, R., Debraekeleer, A., Asche, C., Tegtmeyer, N., Kalali, B., Bach, N.C., Sieber, S.A., Hill, D., Koeniger, V., Hauck, C., Moskalenko, R., Haas, R., Busch, D., Klaile, E., Slevogt, H., Schmidt, A., Backert, S., Remaut, H., Singer, B., Gerhard, M., "Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs", 
Nature Microbiology. doi

Lehmann, J.*, Vomacka, J.*,Esser, K.*, Nodwell, M., Kolbe, K., Rämer, P., Protzer, U., Reiling, N.*, Sieber, S.A.*, "Human lysosomal acid lipase inhibitor lalistat impairs Mycobacterium tuberculosis growth by targeting bacterial hydrolases",
Med. Chem. Commun. doi

Wright, M.H.*, Sieber S.A., "Chemical proteomics approaches for identifying the cellular targets of natural products",
Nat. Prod. Rep. doi

Kirmeier, T.*, Gopalakrishnan, R.*, Gormanns, V.*, Werner, A.M., Cuboni, S., Rudolf, G.C., Höfner, G., Wanner, K.T., Sieber, S.A., Schmidt, U., Holsboer, F., Rein, T.*, Hausch, F.*, "Azidobupramine, an Antidepressant-Derived Bifunctional Neurotransmitter Transporter Ligand Allowing Covalent Labeling and Attachment of Fluorophores",

Lehmann, J., Wright, M.H., Sieber, S.A.*, "Making a long journey short - alkyne functionalization of natural product scaffolds",
Chemistry - A European Journal doi

Gersch, M.*, Stahl, M.*, Poreba, M.*, Dahmen, M., Dziedzic, A., Drag, M.*, Sieber, S.A.*, "Barrel-shaped ClpP proteases display attenuated cleavage specificities",
ACS Chemical Biology doi

Vomacka, J., Korotkov, V.S., Bauer, B., Weinandy, F., Kunzmann, M.H., Krysiak, J., Baron, O., Böttcher, T., Lorenz-Baath, K., Sieber, S.A.*, "An aromatic hydroxyamide attenuates multiresistant Staphylococcus aureus toxin expression",
Chemistry - A European Journal doi

Zhao, W., Lorenz, N., Jung, K., Sieber, S.A.*, "Fimbrolide natural products disrupt bioluminescence of Vibrio by targeting autoinducer biosynthesis and luciferase activity",
Angew. Chem. Int. Ed. doi


Pahl, A.*, Lakemeyer, M.*, Vielberg, M.-T.*, Hackl, M.W., Vomacka, J., Korotkov, V.S., Stein, M., Fetzer, C., Lorenz-Baath, K., Richter, K., Waldmann, H., Groll, M.*, Sieber, S.A.*, "Reversible inhibitors arrest ClpP in a defined conformational state that can be revoked by ClpX association",
Angew. Chem. Int. Ed. doi

Heydenreuter, W., Kunold, E., Sieber, S.A., "Alkynol natural products target ALDH2 in cancer cells by irreversible binding to the active site",
Chem. Commun. doi

Koch, M.F.*, Harteis, S.*, Blank, I.D., Pestel, G., Tietze, L.F., Ochsenfeld, C., Schneider, S.*, and Sieber, S.A.*, "Structural, biochemical and computational studies reveal the mechanism of selective aldehyde dehydrogenase 1A1 inhibition by cytotoxic duocarmycin analogs",
Angew. Chem. Int. Ed. doi

Hackl, M.W.*, Lakemeyer, M.*, Dahmen, M., Glaser, M., Pahl, A., Lorenz-Baath, K., Menzel, T., Sievers, S., Böttcher, T., Antes, I., Waldmann, H., Sieber, S.A., "Phenyl esters are potent inhibitors of caseinolytic protease P and reveal a stereogenic switch for de-oligomerization",
J. Am. Chem. Soc. doi

Wiedemann, E.N.*, Mandl, F.A.*, Blank, I.D.*, Ochsenfeld,C. , Ofial, A.R, Sieber, S.A., "Kinetic and theoretical studies of beta-lactone reactivity – a quantitative scale for biological application",
ChemPlusChem doi

Gersch, M.*, Famulla, K.*, Dahmen M., Göbl, C., Malik, I., Richter, K., Korotkov, V.S., Sass, P., Rübsamen-Schaeff, H., Madl, T., Brötz-Oesterhelt, H., Sieber, S.A., "AAA+ chaperones and acyldepsipeptides activate the ClpP protease via conformational control",
Nature Communications doi

Dahmen, M.*, Vielberg, M.-T.*, Groll, M., Sieber, S.A., "Structure and mechanism of the caseinolytic protease ClpP1/2 heterocomplex from Listeria monocytogenes",
Angew. Chem. Int. Ed. doi

Gersch, M., Hackl, M., Dubiella, C., Dobrinevski, A., Groll, M., Sieber S.A., "Intact protein mass spectrometry of 20S proteasomes reveals complex integrity, phosphorylation stoichiometry and inhibitor specificity",
Chemistry & Biology doi


Artola, M., Ruiz-Avila, L.B., Vergoñós, A., Huecas, S., Araujo-Bazán, L., Martín-Fontecha, M., Vázquez-Villa, H., Turrado, C., Ramírez-Aportela, E., Hoegl, A., Nodwell, M., Barasoain, I., Chacón, P., Sieber, S.A., Andreu, J.M., López-Rodríguez, M.L., "Effective GTP-replacing FtsZ Inhibitors and Antibacterial Mechanism of Action",
ACS Chemical Biology doi

Rudolf*, G.C., Koch*, M.F., Mandl, F.A.M., Sieber, S.A., "Subclass-Specific Labeling of Protein-Reactive Natural Products with Customized Nucleophilic Probes",
Chemistry - A European Journal doi

Harvey, N.L., Krysiak, J., Chamni, S., Cho, S.W., Sieber, S.A., Romo, D., "Synthesis of (±)-Spongiolactone Enabling Discovery of a More Potent Derivative",
Chemistry - A European Journal doi

Kreuzer, J., Bach, N.C., Forler, D., Sieber, S.A., "Target discovery of acivicin in cancer cells elucidates its mechanism of growth inhibition",
Chem. Sci. doi

Dubiella, C., Cui, H., Gersch, M., Brouwer, A.J., Sieber, S.A., Krüger, A., Liskamp, R.M.J., Groll, M., "Selective Inhibition of the Immunoproteasome by Ligand-Induced Crosslinking of the Active Site",
Angew. Chem. doi

Eirich, J., Braig, S., Schyschka, L., Servatius, P., Hoffmann, J., Hecht, S., Fulda, S., Zahler, S., Antes, I., Kazmaier, U., Sieber, S.A.*, Vollmar, A.M.*, "A small molecule protein disulfide inhibitor triggers chemosensitization of cancer cells",
Angew. Chem. doi

Wüstner, F., Mejías-Luque, R., Koch, M., Rath, E., Vieth, M., Sieber, S.A., Haller, D., Gerhard, M., "H. pylori γ-glutamyltranspeptidase impairs T lymphocyte function by compromising metabolic adaption through inhibition of cMyc and IRF4 expression",
Cellular Microbiology doi

Nodwell, M. B., Koch, M. F., Alte, F., Schneider, S., Sieber, S. A., "A Subfamily of Bacterial Ribokinases Utilizes a Hemithioacetal for Pyridoxal Phosphate Salvage",
J. Am. Chem. Soc. doi

Weinandy, F., Lorenz-Baath, K., Korotkov, V. S., Böttcher, T., Sethi, S., Chakraborty, T., Sieber, S. A., "A β-Lactone-Based Antivirulence Drug Ameliorates Staphylococcus aureus Skin Infections in Mice",
ChemMedChem, 2014. doi

Kunzmann, M. H., Bach, N. C., Bauer, B., Sieber, S. A., "α-Methylene-γ-butyrolactones attenuate Staphylococcus aureus virulence by inhibition of transcriptional regulation",
Chem. Sci., 2014. doi

Kolb, R., Bach, N.C., Sieber, S.A., "β-Sultams exhibit discrete binding preferences for diverse bacterial enzymes with nucleophilic residues",
ChemComm, 2014. doi

Gersch, M., Kolb, R., Alte, F., Groll, M., Sieber, S.A., "Disruption of oligomerization and dehydroalanine formation as mechanisms for ClpP protease inhibition",
J. Am. Chem. Soc., 2014. doi

List*, A., Zeiler*, E., Gallastegui, N., Rusch, M., Hedberg, C., Sieber, S.A., Groll, M., "Omuralide and Vibralactone: Differences in the Proteasome- β-Lactone-γ-Lactam Binding Scaffold Alter Target Preferences",
Angew. Chem., 2014. doi


Rudolf, G.C., Sieber, S.A., "Copper-Assisted Click Reactions for Activity-Based Proteomics: Fine-Tuned Ligands and Refined Conditions Extend the Scope of Application",
ChemBioChem, 2013. doi

Wolf, E., Zeißler, A., Vosyka O., Zeiler E., Sieber S.A., Verhelst S.H.L., "A New Class of Rhomboid Protease Inhibitors Discovered by Activity-Based Fluorescence Polarization",
PLOS ONE, 2013, 8(8), e72307. doi

Zeiler, E., List, A., Alte, F., Gersch, M., Wachtel, R., Poreba, M., Drag, M., Groll*, M., Sieber*, S.A., "Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad",
Proc. Natl. Acad. Sci. USA, 2013, 110(28), 11302-11307. doi

Wirth, T., Pestel, G.F., Ganal, V., Kirmeier, T., Schuberth, I., Rein, T., Tietze*, L.F., Sieber*, S.A., "The two faces of potent antitumor duocarmycin based drugs: A structural dissection reveals disparate motifs for DNA versus ALDH1A1 affinity",
Angew. Chem. Int. Ed. 2013, 52(27), 6921–6925. doi

Gersch, M., Gut, F., Korotkov, V., Lehmann, J., Böttcher, T., Rusch, M., Hedberg, C., Waldmann, H., Klebe, G., Sieber, S.A., "The Mechanism of Caseinolytic Protease (ClpP) Inhibition",
Angew. Chem. Int. Ed. 2013, 52, 3009-3014. doi


Rudolf, G.C., Heydenreuter, W., Sieber*, S.A., "Chemical proteomics: ligation and cleavage of protein modifications",
Current Opinion in Chemical Biology 2012, 17(1), 110-117. doi

Battenberg, O.A., Yang, Y., Verhelst, S.H.L., Sieber*, S.A., "Target profiling of 4-hydroxyderricin in S. aureus reveals seryl-tRNA synthetase binding and inhibition by covalent modification",
Mol. BioSyst. 2012, 9, 343-351. doi

Zhang, Y., Madl, T., Bagdiul, I., Kern, T., Kang, H.-S., Zou, P., Mäusbacher, N., Sieber, S.A., Kramer, A., Sattler*, A., "Structure, phosphorylation and U2AF65 binding of the N-terminal domain of splicing factor 1 during 3′-splice site recognition",
Nucl. Acids Res. 2012, 41(2), 1343-1354. doi

Kunzmann, M., Sieber*, S.A., "Target analysis of α-alkylidene-γ-butyrolactones in uropathogenic E. coli",
Mol. BioSyst. 2012, 8, 3061-3067. doi

Lorenz-Baath, K., Korotkov, V., Sieber*, S.A., "In vitro percutaneous absorption of 14C-labeled beta-lactone promises topical delivery of new bacterial virulence inhibitors",
Chem. Med. Chem. 2012, 7 (8), 1490-1495. doi

Eirich, J., Burkhart, J.L., Ullrich, A., Rudolf, G.C., Vollmar, A., Zahler, S., Kazmaier*, U., Sieber*, S.A., "Pretubulysin derived probes as novel tools for monitoring the microtubule network via Activity-Based Protein Profiling and Fluorescence Microscopy",
Mol. Bio. Sys. 2012, 8, 2067-2075. doi

Nodwell, M.B., Menz, H., Kirsch, S.F., Sieber*, S.A., "Rugulactone and its Analogues Exert Antibacterial Effect Through Multiple Mechanisms Including Inhibition of Thiamine Biosynthesis",
Chem. Bio. Chem. 2012, 13 (10), 1439-1446. doi

Krysiak, J.M., Kreuzer, J., Macheroux, P., Hermetter, A., Sieber*, S.A., Breinbauer*, R., "Novel activity-based probes for studying the activity of flavin-dependent oxidases and for the protein target profiling of MAO-inhibitors",
Angew. Chem. 2012, 51 (28), 7035-7040. doi

Pitscheider, M., Mäusbacher, N., Sieber*, S.A., “Antibiotic activity and target discovery of three-membered natural product-derived heterocycles in pathogenic bacteria”,
Chem. Sci., 2012, 3, 2035-2041. doi

Gersch, M., Kreuzer, J., Sieber*, S.A., "Electrophilic natural products and their biological targets",
Nat. Prod. Rep., 2012, 29, 659-682. doi.

Gersch, M., List, A., Groll, M., Sieber*, S.A., "Insights into the structural network responsible for oligomerization and activity of the bacterial virulence regulator caseinolytic protease P (ClpP)",
J. Biol. Chem., 2012, 287 (12), 9484-9494. doi

Wirth, T., Schmuck, K., Tietze, L.F., Sieber*, S.A., "Novel mode of action: Duocarmycin analogs target aldehyde dehydrogenase1 in lung cancer cells",
Angew. Chem. Int. Ed., 2012, 51 (12), 2874-2877. doi

Boettcher, T., Sieber*, S.A., "β-Lactams and β-lactones as activity-based probes in chemical biology"
Med. Chem. Commun., 2012, 3, 408-417. doi


Nodwell, M.B., Sieber*, S.A., "ABPP Methodology: Introduction and Overview"
Topics in Current Chemistry, 2011, 1-41. doi

Zeiler, E., Braun, N., Böttcher, T., Kastenmüller, A., Weinkauf, S., Sieber*, S.A., "Vibralactone as a tool to unravel the activity and structure of the Listeria monocytogenes ClpP1P2 complex"
Angew. Chem. Int. Ed., 2011,50 (46), 11001-11004. doi

Zeiler, E., Korotkov, V.S., Lorenz-Baath, K., Böttcher, T., Sieber*, S.A., "Development and characterization of improved β-lactone-based anti-virulence drugs targeting ClpP"
Bioorg. Med. Chem., 2011, 20 (2), 583-591. doi

Rusch, M., Zimmermann, T.J., Bürger, M., Dekker, F.J., Görmer, K., Triola, G., Brockmeyer, A., Janning, P., Böttcher, T., Sieber, S.A., Vetter, I.R., Hedberg*, C., Waldmann*, H., "Identification of Acyl Protein Thioesterases 1 and 2 as the Cellular Targets of the Ras-Signalling Modulators Palmostatin B and M"
Angew. Chem. Int. Ed., 2011, 123 (42), 10006-10011. doi

Globisch, D., Pearson, D., Hienzsch, A., Brückl, T., Wagner, M., Thoma, I., Thumbs, P., Reiter, V., Kneuttinger, A.-C., Müller, M., Sieber, S.A., Carell*, T., "Systems-Based Analysis of Modified tRNA Bases"
Angew. Chem. Int. Ed., 2011, 50 (41), 9739-9742. doi

Eirich, J., Orth, R., Sieber*, S.A., "Unraveling the protein targets of vancomycin in living S. aureus and E. faecalis cells"
J. Am. Chem. Soc., 2011, 133 (31), 12144-12153. doi

Battenberg, O., Nodwell, M., Sieber*, S.A., "Evaluation of alpha-pyrones and pyrimidones as photoaffinity probes for affinity based protein profiling"
J. Org. Chem., 2011, 76 (15), 6075-6087. doi

Geiger, S.R., Böttcher, T., Sieber*, S.A. and Cramer*, P., "A conformational switch underlies ClpP protease function"
Angew. Chem. Int. Ed., 2011, 50 (25), 5749-5752. doi

Kunzmann, M.H., Staub, I., Böttcher, T. and Sieber, S.A., "Protein Reactivity of Natural Product-Derived y-Butyrolactones"
Biochem., 2011, 50 (5), 910-916. doi


Gersch, M., Sieber, S.A., "Disarming Clostridium difficile"
Chemistry & Biology, 2010, 17, 1165-1166. doi

Orth, R., Böttcher, T. and Sieber, S.A., "The biological targets of acivicin inspired 3-chloro- and 3-bromodihydroisoxazole scaffolds"
ChemComm, 2010, 46, 8475-8477. doi

Rathore, S., Sinha, D., Asad, M., Böttcher, T., Afreen, F., Chauhan, V. S., Gupta, D., Sieber, S. A., Mohmmed, A., "A cyanobacterial serine protease of Plasmodium falciparum is targeted to the apicoplast and plays an important role in its growth and development"
Mol. Microbiol, 2010, 77 (4), 873–890. doi

Orth, R., Pitscheider, M. and Sieber, S.A., "Chemical probes for the labeling of the bacterial glucosaminidase NagZ via the Huisgen cycloaddition"
Synthesis, 2010, (13), 2201–2206. doi

Böttcher, T.; Sieber, S.A., “Showdomycin as a versatile chemical tool for the detection of pathogenesis associated enzymes in bacteria”
J. Am. Chem. Soc., 2010, 132 (20), 6964–6972. doi

Böttcher, T., Pitscheider, M. and Sieber, S.A., “Natural Products and Their Biological Targets: Proteomic and Metabolomic Labeling Strategies”
Angewandte Chemie, 2010, 49 (15), 2680–2698. doi

Sieber, S.A.; Böttcher, T.; Staub, I.; Orth, R., “Comprehensive Natural Products II: Chemistry and Biology”,
Elsevier Science & Technology, ISBN: 978-0080453811.


Orth, R., Sieber, S. A., “A photolabile linker for the mild and selective cleavage of enriched biomolecules from solid support”
J. Org. Chem., 2009, 74 (21), 8476–8479. doi

Pitscheider, M., Sieber, S. A., “Cinnamic aldehyde derived probes for the active site labelling of pathogenesis associated enzymes”
Chem. Comm., 2009, 3741–3743. doi

Böttcher, T., and Sieber, S. A., “beta-Lactones decrease the intracellular virulence of Listeria monocytogenes in macrophages”
ChemMedChem, 2009, 4, 1260–1263. doi

Staub, I., and Sieber, S. A., "beta-Lactam probes as selective chemical-proteomic tools for the identification and functional characterization of resistance associated enzymes in MRSA"
J. Am. Chem. Soc., 2009, 131, 6271–6276. doi

Sieber, S. A., “Unraveling the secrets of protein-metabolite interactions”
ChemBioChem, 2009, 10, 799–801. doi

Böttcher, T., Sieber, S. A., “Structurally Refined β-Lactones as Potent Inhibitors of Devastating Bacterial Virulence Factors”
ChemBioChem, 2009, 10, 663–666. doi


Böttcher, T., Sieber, S. A., “beta-Lactones as specific inhibitors of ClpP attenuate the production of extracellular virulence factors of Staphylococcus aureus”
J. Am. Chem. Soc., 2008, 130, 14400–14401. doi

Staub, I., and Sieber, S. A., "beta-Lactams as Selective Chemical Probes for the in Vivo Labeling of Bacterial Enzymes Involved in Cell Wall Biosynthesis, Antibiotic Resistance, and Virulence"
J. Am. Chem. Soc., 2008, 130, 13400–13407. doi

Böttcher, T., and Sieber, S. A., "beta-Lactones as Privileged Structures for the Active-Site Labeling of Versatile Bacterial Enzyme Classes"
Angewandte Chemie, 2008, 47, 4600–4603. doi

S. A. Sieber, T. Böttcher, 2008, “Sensitive und selektive Inhibition von bakteriellen Virulenzfaktoren in lebenden Zellen mittels beta-Lacton Molekülen. Neue Angriffsziele für Antibiotika“. Europäische Patentanmeldung.


Sieber, S. A., Niessen, S., Hoover, H. S., Cravatt, B. F., "Proteomic Profiling of Metalloproteases with Cocktails of Active-Site Directed Probes"
Nature Chemical Biology 2006, 5, 274–281.

Sieber, S. A., Cravatt, B. F., "Analytical Platforms for Activity-Based Protein Profiling: the Versatility of Chemistry Applied to Functional Proteomics"
Chemical Communications 2006, 22, 2311–2319.

Balakrishnan, A., Patel, B., Sieber, S. A., Pachikara, N., Zhong, G., Cravatt, B. F., Fan, H., “Metalloprotease Inhibitors GM6001 and TAPI-0 Inhibit the Obligate Intracellular Human Pathogen Chlamydia trachomatis by Targeting Polypeptide Deformylase of the Bacterium”
J. Biol. Chem. 2006, 281, 16691–16699.

Wagner, B., Sieber, S. A., Baumann, M., Marahiel, M. A., “Solvent Engineering Substantially Enhances the Chemoenzymatic Production of Surfaction“
ChemBioChem. 2006, 4, 595–587.


Grünewald, J., Kopp, F., Mahlert, C., Linne, U., Sieber, S. A., Marahiel, M. A. “Fluorescence Resonance Energy Transfer as a Probe of Peptide Cyclization by Nonribosomal Thioesterase Domains“
Chem. & Biol. 2005, 8, 873–881.

Mahlert C., Sieber, S. A., Grünewald, J., Marahiel, M. A. “Chemoenzymatic Approach to Enantiopure Streptogramin B Variants: Characterization of Stereoselective Pristinamycin I Cyclase from Streptomyces Pristinaespiralis“
J. Am. Chem. Soc. 2005, 127, 9571–9580.

Sieber, S. A., Marahiel, M. A. “ Molecular Mechanisms Underlying Nonribosomal Peptide Synthesis: Approaches to New Antibiotics”
Chemical Reviews. 2005, 105, 715–738.


Sieber, S. A., Mondala, T. S., Head, S. R., Cravatt, B. F. “Microarray Platform for Profiling Enzyme Activities in Complex Proteomes”
J. Am. Chem. Soc. 2004, 126, 15640–15641.

Grünewald, J., Sieber, S. A., Mahlert, C., Linne, U., Marahiel, M. A. “Synthesis and Derivatization of Daptomycin: A Chemoenzymatic Route to Novel Acidic Lipopeptide Antibiotics”
J. Am. Chem. Soc. 2004, 126, 17025–17031.

Garbe, D., Sieber, S. A., Bandur, N., Koert, U., Marahiel, M. A. “Enzymatic Cyclization of Peptidomimetics with incorporated (E)-Alkene-Dipeptideisosteres“
ChemBioChem. 2004, 5, 1000–1003.

Grünewald, J.*, Sieber, S. A.*, Marahiel, M. A. “ Chemo- and Regioselective Peptide Cyclization triggered by the N-terminal Fatty Acid Chain Length: The Recombinant Cyclase of the Calcium-dependent Antibiotic from Streptomyces coelicolor”
Biochemistry. 2004, 43 2915–2925.

Sieber, S. A., Tao, J., Walsh, C. T., Marahiel, M. A. “Peptidyl thiophenols as substrates for nonribosomal peptide cyclases “.
Angewandte Chemie. 2004, 116, 449–504.


Sieber, S. A., Marahiel, M. A. “Learning from Nature´s drug factories: Nonribosomal Synthesis of cyclic peptides”
J. Bacteriol. 2003, 185, 7036–7043.

Clugston, S. L., Sieber, S. A., Marahiel, M. A., Walsh, C. T. “Chirality of peptide-bond forming condensation domains in nonribosomal peptide synthetases: The C5 domain of tyrocidine synthetase is a DCL catalyst”
Biochemistry. 2003, 42, 12095–12104.

Sieber, S. A., Walsh, C. T., Marahiel, M. A. “Loading peptidyl-coemzyme A onto peptidyl carrier proteins – a novel approach in characterizing macrocyclization by thioesterase domains”
J. Am. Chem. Soc. 2003, 125, 10862–10866.

Sieber, S. A., Marahiel, M. A. “Antibiotika vom molekularen Fließband: Modulare Peptidsynthetasen als Biokatalysatoren“
Biospektrum, 2003, Sonderausgabe, 9. Jahrgang.

M. A. Marahiel, S. A. Sieber, 2003, “Verfahren zur Herstellung zyklischer Moleküle“. Deutsche Patenturkunde DE 103 35 584 B4


Tseng, C. C.*, Bruner, S. D., Kholi, R. M., Marahiel, M. A., Walsh, C. T., Sieber, S. A.* “Characterization of the surfactin C-terminal thioesterase domain as a cyclic depsipeptide synthase“
Biochemistry. 2002, 41, 13350–13359.

Sieber, S. A.*, Linne, U.*, Hillson, N. J., Roche, E., Walsh, C. T., Marahiel, M. A. “Evidence for a monomeric structure of nonribosomal peptide synthetases“
Chem. & Biol., 2002, 9, 997–1008.

Edmundson, M. J., Zhou, W., Sieber, S. A., Jones, I. P., Gameson, I., Anderson, P. H., Edwards, P. P. “Electron beam induced growth of bare silver nanowires from zeolite crystallites“
Advanced Materials, 2001, 13, 1608.

*these authors contributed equally to this work or are equal corresponding authors