New Publication in Angewandte Chemie

TUM Pressemitteilung
TUM press release

Trick and treat: A β-lactone that acts as an electrophilic mimic of mycolic acid blocks serine hydrolases essential for mycomembrane biosynthesis. Activity-based protein profiling paired with metabolic labeling studies confirmed the mechanism of action responsible for the potent antibiotic activity of this compound against Mycobacterium tuberculosis.

Lehmann, J., Cheng, T.Y., Aggarwal, A., Park, A.S., Zeiler, E., Raju, R.M., Akopian, T., Kandror, O., Bach, N.C., Sacchettini, J.C., Moody, D.B., Rubin, E.J., Sieber, S.A., "An Antibacterial β-Lactone Kills Mycobacterium tuberculosis by Disrupting Mycolic Acid Biosynthesis", Angew. Chem. Int. Edit. 2018, 57, 348-353.

Link: 10.1002/anie.201709365

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