Full Publication List

Publication List (without conference proceedings)

Lab members in bold letters.

 

2022

Tellez-Isaias, G.; Eisenreich, W.; Shehata, A.A. Nutraceuticals to Mitigate the Secret Killers in Animals. Vet. Sci. 2022, 9, 435. https://doi.org/10.3390/vetsci9080435

Eisenreich W, Rudel T, Heesemann J and Goebel W (2022) Link Between Antibiotic Persistence and Antibiotic Resistance in Bacterial Pathogens. Front. Cell. Infect. Microbiol. 12:900848.
doi: 10.3389/fcimb.2022.900848

Opdensteinen P, Sperl L, Mohamadi M, Kündgen-Redding N, Hagn F and Buyel J, The transient expression of recombinant proteins in plant cell packs facilitates stable isotope labeling for NMR spectroscopy, Plant Biotechnol J (2022) in press, (https://doi.org/10.1111/pbi.13873)

Günsel U and Hagn F, Lipid nanodiscs for high-resolution NMR studies of membrane proteins, Chem Rev 122 (2022), 9395–9421 (https://doi.org/10.1021/acs.chemrev.1c00702)

Schuhmann P, Engstler C, Klöpfer K, Gügel IL, Abbadi A, Dreyer F, Leckband G, Bölter B, Hagn F, Soll J, and Carrie C, Two wrongs make a right: Heat stress reversion of a male-sterile Brassica napus line. J Exp Bot (2022), 73 (11), 3531–3551, (https://doi.org/10.1093/jxb/erac082)

Paper M, Glemser M, Haack M, Lorenzen J, Mehlmer N, Fuchs T, Schenk G, Garbe D, Weuster-Botz D, Eisenreich W, Lakatos M, Brück TB. Efficient Green Light Acclimation of the Green Algae Picochlorum sp. Triggering Geranylgeranylated Chlorophylls. Front Bioeng Biotechnol. 2022 Apr 28;10:885977. doi: 10.3389/fbioe.2022.885977. eCollection 2022. PMID: 35573232.

Ringel M, Dimos N, Himpich S, Haack M, Huber C, Eisenreich W, Schenk G, Loll B, Brück T. Biotechnological potential and initial characterization of two novel sesquiterpene synthases from Basidiomycota Coniophora puteana for heterologous production of δ-cadinol. Microb Cell Fact. 2022 Apr 19;21(1):64. doi: 10.1186/s12934-022-01791-8. PMID: 35440053.

Riegel AD, Wakabayashi H, Wakabayashi M, Rynešová M, Dudko V, Eisenreich W, Engel KH. Configurations and Sensory Properties of the Stereoisomers of 2,6-Dimethyl-4-propyl-1,3-oxathiane and 2,4-Dimethyl-6-propyl-1,3-oxathiane. J Agric Food Chem. 2022 Apr 20;70(15):4712-4724. doi: 10.1021/acs.jafc.2c00509. Epub 2022 Apr 5. PMID: 35380838.

Steffens L, Pettinato E, Steiner TM, Eisenreich W, Berg IA.Tracking the Reversed Oxidative Tricarboxylic Acid Cycle in Bacteria. Bio Protoc. 2022 Mar 20;12(6):e4364. doi: 10.21769/BioProtoc.4364. eCollection 2022 Mar 20. PMID: 35434198.

Coskun ÖK, Vuillemin A, Schubotz F, Klein F, Sichel SE, Eisenreich W, Orsi WD. Correction to: Quantifying the effects of hydrogen on carbon assimilation in a seafloor microbial community associated with ultramafic rocks. ISME J. 2022 Mar;16(3):900. doi: 10.1038/s41396-021-01087-6. PMID: 34848847.

Acheuk F, Basiouni S, Shehata AA, Dick K, Hajri H, Lasram S, Yilmaz M, Emekci M, Tsiamis G, Spona-Friedl M, May-Simera H, Eisenreich W, Ntougias S. Status and Prospects of Botanical Biopesticides in Europe and Mediterranean Countries. Biomolecules. 2022 Feb 15;12(2):311. doi: 10.3390/biom12020311. PMID: 35204810. Review.

Shehata AA, Yalçın S, Latorre JD, Basiouni S, Attia YA, Abd El-Wahab A, Visscher C, El-Seedi HR, Huber C, Hafez HM, Eisenreich W, Tellez-Isaias G. Probiotics, Prebiotics, and Phytogenic Substances for Optimizing Gut Health in Poultry. Microorganisms. 2022 Feb 8;10(2):395. doi: 10.3390/microorganisms10020395. PMID: 35208851. Review.

Asimakis E, Shehata AA, Eisenreich W, Acheuk F, Lasram S, Basiouni S, Emekci M, Ntougias S, Taner G, May-Simera H, Yilmaz M, Tsiamis G. Algae and Their Metabolites as Potential Bio-Pesticides. Microorganisms. 2022 Jan 27;10(2):307. doi: 10.3390/microorganisms10020307. PMID: 35208762. Review.

 

2021

Weiss AS, Burrichter AG, Durai Raj AC, von Strempel A, Meng C, Kleigrewe K, Münch PC, Rössler L, Huber C, Eisenreich W, Jochum LM, Göing S, Jung K, Lincetto C, Hübner J, Marinos G, Zimmermann J, Kaleta C, Sanchez A, Stecher B. In vitro interaction network of a synthetic gut bacterial community. ISME J. 2022 Apr;16(4):1095-1109. doi: 10.1038/s41396-021-01153-z. Epub 2021 Dec 2. PMID: 34857933.

Spier A, Connor MG, Steiner T, Carvalho F, Cossart P, Eisenreich W, Wai T, Stavru F. Mitochondrial respiration restricts Listeria monocytogenes infection by slowing down host cell receptor recycling. Cell Rep. 2021 Nov 9;37(6):109989. doi: 10.1016/j.celrep.2021.109989. PMID: 34758302.

Sperl LE, Rührnößl F, Schiller A, Haslbeck M and Hagn F, High-resolution analysis of the conformational transition of pro-apoptotic Bak at the lipid membrane, EMBO J (2021), e107159 (https://doi.org/10.15252/embj.2020107159) - Highlighted in: Ojoawo & Moldoveanu, A killer metamorphosis: catching BAK in action at the membrane, EMBO J (2021), e109529 (https://doi.org/10.15252/embj.2021109529)

Seitz C, Eisenreich W, Huber C. The Abiotic Formation of Pyrrole under Volcanic, Hydrothermal Conditions-An Initial Step towards Life's First Breath? Life (Basel). 2021 Sep 17;11(9):980. doi: 10.3390/life11090980. PMID: 34575129.

Coskun ÖK, Vuillemin A, Schubotz F, Klein F, Sichel SE, Eisenreich W, Orsi WD. Quantifying the effects of hydrogen on carbon assimilation in a seafloor microbial community associated with ultramafic rocks. ISME J. 2022 Jan;16(1):257-271. doi: 10.1038/s41396-021-01066-x. Epub 2021 Jul 26. PMID: 34312482.

Sperl LE and Hagn F, NMR structural and biophysical analysis of the disease-linked inner mitochondrial membrane protein MPV17, J Mol Biol 433 (2021), 167098 (https://authors.elsevier.com/a/1dGQ954HFK6-N)

Steiner TM, Lettl C, Schindele F, Goebel W, Haas R, Fischer W, Eisenreich W. Substrate usage determines carbon flux via the citrate cycle in Helicobacter pylori. Mol Microbiol. 2021 Sep;116(3):841-860. doi: 10.1111/mmi.14775. Epub 2021 Jul 8. PMID: 34164854.

Baur S, Frank O, Hausladen H, Hückelhoven R, Hofmann T, Eisenreich W, Dawid C. Biosynthesis of α-solanine and α-chaconine in potato leaves (Solanum tuberosum L.) - A 13CO2 study. Food Chem. 2021 Dec 15;365:130461. doi: 10.1016/j.foodchem.2021.130461. Epub 2021 Jun 25. PMID: 34229992.

Feuerecker B, Biechl P, Veltkamp C, Saur D, Eisenreich W. Metabolic Response of Pancreatic Carcinoma Cells under Treatment with Dichloroacetate. Metabolites. 2021 May 30;11(6):350. doi: 10.3390/metabo11060350. PMID: 34070873.

Kunze M, Steiner T, Chen F, Huber C, Rydzewski K, Stämmler M, Heuner K, Eisenreich W. Metabolic adaption of Legionella pneumophila during intracellular growth in Acanthamoeba castellanii. Int J Med Microbiol. 2021 May;311(4):151504. doi: 10.1016/j.ijmm.2021.151504. Epub 2021 Apr 19. PMID: 33906075.

Steffens L, Pettinato E, Steiner TM, Mall A, König S, Eisenreich W, Berg IA. High CO2 levels drive the TCA cycle backwards towards autotrophy. Nature. 2021 Apr;592(7856):784-788. doi: 10.1038/s41586-021-03456-9. Epub 2021 Apr 21. PMID: 33883741.

Rajeeve K, Vollmuth N, Janaki-Raman S, Wulff TF, Baluapuri A, Dejure FR, Huber C, Fink J, Schmalhofer M, Schmitz W, Sivadasan R, Eilers M, Wolf E, Eisenreich W, Schulze A, Seibel J, Rudel T. Author Correction: Reprogramming of host glutamine metabolism during Chlamydia trachomatis infection and its key role in peptidoglycan synthesis. Nat Microbiol. 2021 Apr;6(4):533. doi: 10.1038/s41564-021-00874-3. PMID: 33589805.

Feuerecker B, Biechl P, Seidl C, Bruchertseifer F, Morgenstern A, Schwaiger M, Eisenreich W. Diverse metabolic response of cancer cells treated with a 213Bi-anti-EGFR-immunoconjugate. Sci Rep. 2021 Mar 18;11(1):6227. doi: 10.1038/s41598-021-84421-4. PMID: 33737524.

Radziej S, Scherb-Forster J, Schlicht C, Eisenreich W. Fast Identification of Food Thickeners by Nontargeted NMR-Spectroscopy. J Agric Food Chem. 2021 Mar 31;69(12):3761-3775. doi: 10.1021/acs.jafc.0c07760. Epub 2021 Mar 16. PMID: 33724804.

Zhang M, Gui M, Wang Z-F, Gorgulla C, Yu J, Wu H, Sun Z-Y J, Klenk C, Merkinger L, Morstein L, Hagn F, Plückthun A, Brown A, Nasr ML and Wagner G, Cryo-EM structure of an activated GPCR-G protein complex in lipid nanodiscs, Nat Struc Mol Biol 28 (2021), 258–267 (https://doi.org/10.1038/s41594-020-00554-6)

Geisberger T, Sobotta J, Eisenreich W, Huber C. Formation of Thiophene under Simulated Volcanic Hydrothermal Conditions on Earth-Implications for Early Life on Extraterrestrial Planets? Life (Basel). 2021 Feb 16;11(2):149. doi: 10.3390/life11020149. PMID: 33669362.

Eisenreich W, Rudel T, Heesemann J, Goebel W. Persistence of Intracellular Bacterial Pathogens-With a Focus on the Metabolic Perspective. Front Cell Infect Microbiol. 2021 Jan 14;10:615450. doi: 10.3389/fcimb.2020.615450. eCollection 2020. PMID: 33520740. Review.

Goba I, Goricanec D, Schum D, Hillenbrand M, Plückthun A and Hagn F, Probing the Conformational States of Neurotensin Receptor 1 Variants by NMR Site-Directed Methyl Labeling, ChemBioChem 22 (2021), 139-146 (http://dx.doi.org/10.1002/cbic.202000541)

 

2020

Steiner A, Schlepckow K, Brunner B, Steiner H, Haass C and Hagn F, Gamma-secretase cleavage of the Alzheimer risk factor TREM2 is determined by its intrinsic structural dynamics, EMBO J, 39 (2020), e104247, (doi: 10.15252/embj.2019104247)

Lampl S, Janas MK, Donakonda S, Brugger M, Lohr K, Schneider A, Manske K, Sperl LE, Wettmarshausen J, Müller C, Laschinger M, Hartmann D, Hüser N, Perrochi F, Schmitt-Kopplin P, Hagn F, Zender L, Hornung V, Borner C, Pichlmair A, Kashkar H, Klingenspor M, Prinz M, Schreiner S, Conrad M, Jost PJ, Zischka H, Steiger K, Krönke M, Zehn D, Protzer U, Heikenwälder M, Knolle PA and Wohlleber D, Reduced mitochondrial resilience enables non-canonical induction of apoptosis after TNF receptor signaling in virus-infected hepatocytes, J Hepat, 75 (2020), 1347-1359 (doi: 10.1016/j.jhep.2020.06.026)

Häusler E, Fredriksson K, Goba I, Peters C, Raltchev K, Sperl L, Steiner A, Weinkauf S and Hagn F, Quantifying the insertion of membrane proteins into lipid bilayer nanodiscs using a fusion protein strategy, BBA - Biomembranes, 1862 (2020), 183-190 (doi: 10.1016/j.bbamem.2020.183190)

 

2019

Klöpfer K and Hagn F, Beyond detergent micelles: the advantages and applications of non-micellar and lipid-based membrane mimetics for solution-state NMR, Prog NMR Spectr, 114-115 (2019) 271-283 (doi.org/10.1016/j.pnmrs.2019.08.001)

Hassan L, Lin L, Sorek H, Sperl L, Goudoulas T, Hagn F, Germann N, Tian T and Benz JP, Cross-talk of cellulose and mannan perception pathways leads to inhibition of cellulase production in several filamentous fungi, mBio 

(2019) 10:e00277-19. doi.org/10.1128/mBio.00277-19

Zeng B, Mou T-C, Doukov T I, Steiner A, Yu W, Papasergi-Scott M, Tall GG, Hagn F and Sprang SR. Structure, Function, and Dynamics of the Gα Binding Domain of Ric-8A. Structure 27 (7) (2019), 1137-1147.e5  (doi:10.1016/j.str.2019.04.013)

Goricanec D and Hagn F, NMR backbone and methyl resonance assignments of an inhibitory G-alpha subunit in complex with GDP. Biomol NMR Assign 13 (1) (2019), 131-137 (doi:10.1007/s12104-018-9865-9)

Reif M, Fischer M, Fredriksson K, Hagn F and Zacharias M, The N-terminal segment of the voltage-dependent anion channel: A possible membrane-bound intermediate in pore unbinding. J Mol Biol 431 (2019), 223-243 (doi:10.1016/j.jmb.2018.09.015)

 

2018

Miehling J, Goricanec D, and Hagn F, A split‐intein‐based method for the efficient production of circularized nanodiscs for structural studies of membrane proteins. ChemBioChem, 19 (2018), 1927-1933  (doi:10.1002/cbic.201800345)

Raltchev K, Pipercevic J, and Hagn F, Production and structural analysis of membrane-anchored proteins in phospholipid nanodiscs. Chem Eur J, 24 (21) (2018), 5493-5499 (doi:10.1002/chem.201800812)

Hagn F, Nasr ML and Wagner G, Assembly of phospholipid nanodiscs of controlled size for structural studies of membrane proteins by NMR. Nat Protoc, 13 (2018), 79–98 (doi:10.1038/nprot.2017.094) (F1000 Prime recommended)

 

2017

Rodriguez Camargo DC, Korshavn KJ, Jussupow A, Raltchev K, Goricanec D, Fleisch M, Sarkar R, Xue K, Aichler M, Mettenleiter G, Walch AK, Camilloni C, Hagn F, Reif B and Ramamoorthy A, Stabilization and structural analysis of a membrane-associated hIAPP aggregation intermediate. eLife, 6 (2017), e31226 (doi: 10.7554/eLife.31226

Nasr ML, Baptista D, Strauss M, Sun Z-Y J, Grigoriu S, Huser S, Plückthun A, Hagn F, Walz T, Hogle JM and Wagner G, Covalently circularized nanodiscs for studying membrane proteins and viral entry. Nat Methods 14 (2017), 49-52, (doi:10.1038/nmeth.4079)

 

2016

Goricanec D, Stehle R, Egloff P, Grigoriu S, Plückthun A, Wagner G and Hagn F, Conformational dynamics of a G-protein alpha subunit is tightly regulated by nucleotide binding, Proc Natl Acad Sci USA, 113 (2016), E3629–E3638, doi: 10.1073/pnas.1604125113  (F1000 Prime recommended)

Enthart A, Klein C, Dehner A, Coles M, Gemmecker G, Kessler H and Hagn F, Solution structure and binding specificity of the p63 DNA binding domain, Sci Rep, 6 (2016), 26707, doi: 10.1038/srep26707

 

2015

Milbradt AG, Arthanari H, Takeuchi K, Boeszoermenyi A, Hagn F and Wagner G, Increased resolution of aromatic cross peaks using alternate 13C labeling and TROSY, J Biomol NMR, 62(3) (2015) 291-301

Hagn F, and Wagner G, Structure refinement and membrane positioning of selectively labeled OmpX in phospholipid nanodiscs, J Biomol NMR, 61(3) (2015) 249-260 

 

2014

Linser R, Gelev V, Hagn F, Arthanari H, Hyberts S, and Wagner G, Selective methyl labeling of eukaryotic membrane proteins using cell-free expression, J Am Chem Soc 136 (2014) 11308-10
 

2013

Etzkorn M, Raschle, T, Hagn, F, Gelev V, Rice, AJ, Walz T, and Wagner G, Structural Insights into Cell-Free Expressed Bacteriorhodopsin in Different Soluble Membrane Mimetics. Structure 21 (2013) 394-401

Hagn F, Etzkorn M, Raschle T, and Wagner G, Optimized Phospholipid Bilayer Nanodiscs For High-Resolution Structure Determination of Membrane Proteins. J Am Chem Soc, 135 (2013) 1919-1925, Highlighted in Science 339 (2013) p 1013

 

2012

Demmer O, Frank AO, Hagn F, Schottelius M, Marinelli L, Cosconati S, Brack-Werner R, Kremb S, Wester HJ, and Kessler H, A Conformationally Frozen Peptoid Boosts CXCR4 Affinity and Anti-HIV Activity, Angew Chem Int Ed Engl. 32 (2012) 8110-8113 

Hagn F, A structural view on spider silk proteins and their role in fiber assembly, J Pept Sci, 18, (2012) 357-65  (Review on occasion of the Friedrich-Weygand-award of the Max-Bergmann Kreis)

Schmid A.B, Lagleder S, Gräwert MA, Röhl A, Hagn F, Wandinger SK, Cox MB, Demmer O, Richter K, Groll M, Kessler H, and Buchner J, The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop. EMBO J, 31 (2012) 1506-1517      
 

2011

Hagn F*, Lagleder S*, Retzlaff M*, Rohrberg J, Richter, K, Buchner J and Kessler H, Structural analysis of the interaction of the heat shock protein 90 with the tumor suppressor protein p53. Nat Struct Mol Biol, 18 (2011) 1086-1093                      

Knöll R, Linke WA, Zou P, Miocic S, Kostin S, Buyandelger B, Ku CH, Neef S, Bug M, Schäfer K, Knöll G, Felkin LE, Wessels J, Toischer K, Hagn F, Kessler H, Didié M, Quentin T, Maier LS, Teucher N, Unsöld B, Schmidt A, Birks EJ, Gunkel S, Lang P, Granzier H, Zimmermann WH, Field LJ, Faulkner G, Dobbelstein M, Barton PJ, Sattler M, Wilmanns M, Chien KR, Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart. Circ Res 16 (2011) 758-69 

Hagn F and Kessler H, Struktur und Funktion von Spinnenseiden Proteinen mit NMR Spektroskopie, GIT Labor-Fachzeitschrift, 55 (2011) 838-841 (international edition published in 2012) (Review)

Hagn F, Thamm C, Scheibel T, and Kessler H, pH Dependent Dimerisation and Salt Dependent Stabilisation of the N-terminal Domain of Spider Dragline Silk - Implications for Fibre Formation, Angew Chem Int Ed Engl. 50 (2011), 310-313       
 

2010

Rudolph B, Welker S, Frenzel E, Hagn F, Liebisch G, Schmitz G, Scheuring J, Weinkauf S, Haslbeck M, Kessler H, and Buchner J, Hsp12 is an intrinsically unfolded stress protein which folds upon membrane association and modulates membrane function. Mol Cell 39 (2010), 507-520   

Hagn F, Eisoldt L, Hardy JG, Vendrely C, Coles M, Scheibel T, and Kessler H, A conserved spider silk domain acts as molecular switch that controls fibre assembly, Nature 465 (2010), 239-242  

Hagn F, Klein C, Demmer O, Marchenko N, Vaseva A, Moll UM, and Kessler H, BclxL changes conformation upon binding to wild-type but not mutant p53 DNA binding domain,  J Biol Chem. 285 (2010), 3439-3450 

Retzlaff M.*, Hagn F.*, Mitschke L, Hessling M, Gugel F, Kessler H, Richter K and Buchner J, Asymmetric activation of the Hsp90 dimer by its co-chaperone Aha1, Mol Cell 37 (2010), 344-354
 

2009

Spichty M, Taly A, Hagn F, Kessler H, Barluenga S, Winssinger N, and Karplus M, The HSP90 binding mode of a radicicol-like E-oxime determined by docking, binding free energy estimations, and NMR 15N chemical shifts, Biophys Chem. 143 (2009), 111-23   
 

2007

Feige MJ, Hagn F, Esser J, Kessler H, and Buchner J, Influence of the internal disulfide bridge on the folding pathway of the CL antibody domain, J Mol Biol 365 (2007), 1232-1244  
 

2006

Richter K, Moser S, Hagn F, Friedrich R, Hainzl O, Heller M, Schlee S, Kessler H, Reinstein J, and Buchner J, Intrinsic inhibition of the Hsp90 ATPase activity, J Biol Chem 281 (2006), 11301-11311  

Scholz C, Eckert B, Hagn F, Harrschmidt P, Balbach J, and Schmid FX, SlyD proteins from different species exhibit high prolyl isomerase and chaperone activities. Biochemistry, 45 (2006), 20-33
 

2004

Andersson A, Almqvist J, Hagn F, and Mäler L, Diffusion and dynamics of penetratin in different membrane mimicking media, BBA - Biomembranes, 1661 (2004), 18-25