Full Publication List

Publication List (without conference proceedings)

Lab members in bold letters.


Opdensteinen P, Sperl L, Mohamadi M, Kündgen-Redding N, Hagn F and Buyel J, The transient expression of recombinant proteins in plant cell packs facilitates stable isotope labeling for NMR spectroscopy, Plant Biotechnol J (2022), accepted

Günsel U and Hagn F, Lipid nanodiscs for high-resolution NMR studies of membrane proteins, Chem Rev 122 (2022), 9395–9421 (https://doi.org/10.1021/acs.chemrev.1c00702)

Schuhmann P, Engstler C, Klöpfer K, Gügel IL, Abbadi A, Dreyer F, Leckband G, Bölter B, Hagn F, Soll J, and Carrie C, Two wrongs make a right: Heat stress reversion of a male-sterile Brassica napus line. J Exp Bot (2022), corrected proof available online, (https://doi.org/10.1093/jxb/erac082)



Sperl LE, Rührnößl F, Schiller A, Haslbeck M and Hagn F, High-resolution analysis of the conformational transition of pro-apoptotic Bak at the lipid membrane, EMBO J (2021), e107159 (https://doi.org/10.15252/embj.2020107159) - Highlighted in: Ojoawo & Moldoveanu, A killer metamorphosis: catching BAK in action at the membrane, EMBO J (2021), e109529 (https://doi.org/10.15252/embj.2021109529)

Sperl LE and Hagn F, NMR structural and biophysical analysis of the disease-linked inner mitochondrial membrane protein MPV17, J Mol Biol 433 (2021), 167098 (https://authors.elsevier.com/a/1dGQ954HFK6-N)

Zhang M, Gui M, Wang Z-F, Gorgulla C, Yu J, Wu H, Sun Z-Y J, Klenk C, Merkinger L, Morstein L, Hagn F, Plückthun A, Brown A, Nasr ML and Wagner G, Cryo-EM structure of an activated GPCR-G protein complex in lipid nanodiscs, Nat Struc Mol Biol 28 (2021), 258–267 (https://doi.org/10.1038/s41594-020-00554-6)

Goba I, Goricanec D, Schum D, Hillenbrand M, Plückthun A and Hagn F, Probing the Conformational States of Neurotensin Receptor 1 Variants by NMR Site-Directed Methyl Labeling, ChemBioChem 22 (2021), 139-146 (http://dx.doi.org/10.1002/cbic.202000541



Steiner A, Schlepckow K, Brunner B, Steiner H, Haass C and Hagn F, Gamma-secretase cleavage of the Alzheimer risk factor TREM2 is determined by its intrinsic structural dynamics, EMBO J, 39 (2020), e104247, (doi: 10.15252/embj.2019104247)

Lampl S, Janas MK, Donakonda S, Brugger M, Lohr K, Schneider A, Manske K, Sperl LE, Wettmarshausen J, Müller C, Laschinger M, Hartmann D, Hüser N, Perrochi F, Schmitt-Kopplin P, Hagn F, Zender L, Hornung V, Borner C, Pichlmair A, Kashkar H, Klingenspor M, Prinz M, Schreiner S, Conrad M, Jost PJ, Zischka H, Steiger K, Krönke M, Zehn D, Protzer U, Heikenwälder M, Knolle PA and Wohlleber D, Reduced mitochondrial resilience enables non-canonical induction of apoptosis after TNF receptor signaling in virus-infected hepatocytes, J Hepat, 75 (2020), 1347-1359 (doi: 10.1016/j.jhep.2020.06.026)

Häusler E, Fredriksson K, Goba I, Peters C, Raltchev K, Sperl L, Steiner A, Weinkauf S and Hagn F, Quantifying the insertion of membrane proteins into lipid bilayer nanodiscs using a fusion protein strategy, BBA - Biomembranes, 1862 (2020), 183-190 (doi: 10.1016/j.bbamem.2020.183190)



Klöpfer K and Hagn F, Beyond detergent micelles: the advantages and applications of non-micellar and lipid-based membrane mimetics for solution-state NMR, Prog NMR Spectr, 114-115 (2019) 271-283 (doi.org/10.1016/j.pnmrs.2019.08.001)

Hassan L, Lin L, Sorek H, Sperl L, Goudoulas T, Hagn F, Germann N, Tian T and Benz JP, Cross-talk of cellulose and mannan perception pathways leads to inhibition of cellulase production in several filamentous fungi, mBio 

(2019) 10:e00277-19. doi.org/10.1128/mBio.00277-19

Zeng B, Mou T-C, Doukov T I, Steiner A, Yu W, Papasergi-Scott M, Tall GG, Hagn F and Sprang SR. Structure, Function, and Dynamics of the Gα Binding Domain of Ric-8A. Structure 27 (7) (2019), 1137-1147.e5  (doi:10.1016/j.str.2019.04.013)

Goricanec D and Hagn F, NMR backbone and methyl resonance assignments of an inhibitory G-alpha subunit in complex with GDP. Biomol NMR Assign 13 (1) (2019), 131-137 (doi:10.1007/s12104-018-9865-9)

Reif M, Fischer M, Fredriksson K, Hagn F and Zacharias M, The N-terminal segment of the voltage-dependent anion channel: A possible membrane-bound intermediate in pore unbinding. J Mol Biol 431 (2019), 223-243 (doi:10.1016/j.jmb.2018.09.015)



Miehling J, Goricanec D, and Hagn F, A split‐intein‐based method for the efficient production of circularized nanodiscs for structural studies of membrane proteins. ChemBioChem, 19 (2018), 1927-1933  (doi:10.1002/cbic.201800345)

Raltchev K, Pipercevic J, and Hagn F, Production and structural analysis of membrane-anchored proteins in phospholipid nanodiscs. Chem Eur J, 24 (21) (2018), 5493-5499 (doi:10.1002/chem.201800812)

Hagn F, Nasr ML and Wagner G, Assembly of phospholipid nanodiscs of controlled size for structural studies of membrane proteins by NMR. Nat Protoc, 13 (2018), 79–98 (doi:10.1038/nprot.2017.094) (F1000 Prime recommended)



Rodriguez Camargo DC, Korshavn KJ, Jussupow A, Raltchev K, Goricanec D, Fleisch M, Sarkar R, Xue K, Aichler M, Mettenleiter G, Walch AK, Camilloni C, Hagn F, Reif B and Ramamoorthy A, Stabilization and structural analysis of a membrane-associated hIAPP aggregation intermediate. eLife, 6 (2017), e31226 (doi: 10.7554/eLife.31226

Nasr ML, Baptista D, Strauss M, Sun Z-Y J, Grigoriu S, Huser S, Plückthun A, Hagn F, Walz T, Hogle JM and Wagner G, Covalently circularized nanodiscs for studying membrane proteins and viral entry. Nat Methods 14 (2017), 49-52, (doi:10.1038/nmeth.4079)



Goricanec D, Stehle R, Egloff P, Grigoriu S, Plückthun A, Wagner G and Hagn F, Conformational dynamics of a G-protein alpha subunit is tightly regulated by nucleotide binding, Proc Natl Acad Sci USA, 113 (2016), E3629–E3638, doi: 10.1073/pnas.1604125113  (F1000 Prime recommended)

Enthart A, Klein C, Dehner A, Coles M, Gemmecker G, Kessler H and Hagn F, Solution structure and binding specificity of the p63 DNA binding domain, Sci Rep, 6 (2016), 26707, doi: 10.1038/srep26707



Milbradt AG, Arthanari H, Takeuchi K, Boeszoermenyi A, Hagn F and Wagner G, Increased resolution of aromatic cross peaks using alternate 13C labeling and TROSY, J Biomol NMR, 62(3) (2015) 291-301

Hagn F, and Wagner G, Structure refinement and membrane positioning of selectively labeled OmpX in phospholipid nanodiscs, J Biomol NMR, 61(3) (2015) 249-260 



Linser R, Gelev V, Hagn F, Arthanari H, Hyberts S, and Wagner G, Selective methyl labeling of eukaryotic membrane proteins using cell-free expression, J Am Chem Soc 136 (2014) 11308-10


Etzkorn M, Raschle, T, Hagn, F, Gelev V, Rice, AJ, Walz T, and Wagner G, Structural Insights into Cell-Free Expressed Bacteriorhodopsin in Different Soluble Membrane Mimetics. Structure 21 (2013) 394-401

Hagn F, Etzkorn M, Raschle T, and Wagner G, Optimized Phospholipid Bilayer Nanodiscs For High-Resolution Structure Determination of Membrane Proteins. J Am Chem Soc, 135 (2013) 1919-1925, Highlighted in Science 339 (2013) p 1013



Demmer O, Frank AO, Hagn F, Schottelius M, Marinelli L, Cosconati S, Brack-Werner R, Kremb S, Wester HJ, and Kessler H, A Conformationally Frozen Peptoid Boosts CXCR4 Affinity and Anti-HIV Activity, Angew Chem Int Ed Engl. 32 (2012) 8110-8113 

Hagn F, A structural view on spider silk proteins and their role in fiber assembly, J Pept Sci, 18, (2012) 357-65  (Review on occasion of the Friedrich-Weygand-award of the Max-Bergmann Kreis)

Schmid A.B, Lagleder S, Gräwert MA, Röhl A, Hagn F, Wandinger SK, Cox MB, Demmer O, Richter K, Groll M, Kessler H, and Buchner J, The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop. EMBO J, 31 (2012) 1506-1517      


Hagn F*, Lagleder S*, Retzlaff M*, Rohrberg J, Richter, K, Buchner J and Kessler H, Structural analysis of the interaction of the heat shock protein 90 with the tumor suppressor protein p53. Nat Struct Mol Biol, 18 (2011) 1086-1093                      

Knöll R, Linke WA, Zou P, Miocic S, Kostin S, Buyandelger B, Ku CH, Neef S, Bug M, Schäfer K, Knöll G, Felkin LE, Wessels J, Toischer K, Hagn F, Kessler H, Didié M, Quentin T, Maier LS, Teucher N, Unsöld B, Schmidt A, Birks EJ, Gunkel S, Lang P, Granzier H, Zimmermann WH, Field LJ, Faulkner G, Dobbelstein M, Barton PJ, Sattler M, Wilmanns M, Chien KR, Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart. Circ Res 16 (2011) 758-69 

Hagn F and Kessler H, Struktur und Funktion von Spinnenseiden Proteinen mit NMR Spektroskopie, GIT Labor-Fachzeitschrift, 55 (2011) 838-841 (international edition published in 2012) (Review)

Hagn F, Thamm C, Scheibel T, and Kessler H, pH Dependent Dimerisation and Salt Dependent Stabilisation of the N-terminal Domain of Spider Dragline Silk - Implications for Fibre Formation, Angew Chem Int Ed Engl. 50 (2011), 310-313       


Rudolph B, Welker S, Frenzel E, Hagn F, Liebisch G, Schmitz G, Scheuring J, Weinkauf S, Haslbeck M, Kessler H, and Buchner J, Hsp12 is an intrinsically unfolded stress protein which folds upon membrane association and modulates membrane function. Mol Cell 39 (2010), 507-520   

Hagn F, Eisoldt L, Hardy JG, Vendrely C, Coles M, Scheibel T, and Kessler H, A conserved spider silk domain acts as molecular switch that controls fibre assembly, Nature 465 (2010), 239-242  

Hagn F, Klein C, Demmer O, Marchenko N, Vaseva A, Moll UM, and Kessler H, BclxL changes conformation upon binding to wild-type but not mutant p53 DNA binding domain,  J Biol Chem. 285 (2010), 3439-3450 

Retzlaff M.*, Hagn F.*, Mitschke L, Hessling M, Gugel F, Kessler H, Richter K and Buchner J, Asymmetric activation of the Hsp90 dimer by its co-chaperone Aha1, Mol Cell 37 (2010), 344-354


Spichty M, Taly A, Hagn F, Kessler H, Barluenga S, Winssinger N, and Karplus M, The HSP90 binding mode of a radicicol-like E-oxime determined by docking, binding free energy estimations, and NMR 15N chemical shifts, Biophys Chem. 143 (2009), 111-23   


Feige MJ, Hagn F, Esser J, Kessler H, and Buchner J, Influence of the internal disulfide bridge on the folding pathway of the CL antibody domain, J Mol Biol 365 (2007), 1232-1244  


Richter K, Moser S, Hagn F, Friedrich R, Hainzl O, Heller M, Schlee S, Kessler H, Reinstein J, and Buchner J, Intrinsic inhibition of the Hsp90 ATPase activity, J Biol Chem 281 (2006), 11301-11311  

Scholz C, Eckert B, Hagn F, Harrschmidt P, Balbach J, and Schmid FX, SlyD proteins from different species exhibit high prolyl isomerase and chaperone activities. Biochemistry, 45 (2006), 20-33


Andersson A, Almqvist J, Hagn F, and Mäler L, Diffusion and dynamics of penetratin in different membrane mimicking media, BBA - Biomembranes, 1661 (2004), 18-25