Foto von Friedrich Simmel

Prof. Dr. rer. nat. Friedrich Simmel

Technische Universität München

Lehrstuhl für Physik Synthetischer Biosysteme (Prof. Simmel)


Am Coulombwall 4a
85748 Garching b. München

Scientific career

1999 PhD, Experimental Physics, LMU München
2000 - 2002 Postdoctoral researcher at Bell Laboratories, Murray Hill, NJ, USA
2002 - 2007 Emmy Noether group leader at the Department of Physics, LMU München
2005 Habilitation, Experimental Physics, LMU München
2005 - 2006 Substitute professor (W2) for Physical Chemistry, LMU München
2006 - 2007 Senior lecturer at the Department of Physics, LMU München
2007 - today Full professor (W3) for Experimental Physics, TU München
2010 - 2019 co-Coordinator of the Cluster of Excellence Nanosystems Intiative Munich

Awards & Memberships

2006Human frontier science program (HFSP) young investigator award
2009Vice President of the International Society of Nanoscale Science, Computation and Engineering (ISNSCE)
2010President of the International Society of Nanoscale Science, Computation and Engineering (ISNSCE)
2013Elected Member of the National Academy of Science and Technology (acatech)
2016ERC Advanced Grant
2016Rozenberg Tulip Award in DNA Computing

Most important scientific publications

see also;

A.-K. Pumm, W. Engelen, E. Kopperger, J. Isensee, M. Vogt, V. Kozina, M. Kube, M. N. Honemann, E. Bertosin, M. Langecker, R. Golestanian#, F. C. Simmel#, H. Dietz#, A DNA origami rotary ratchet motor, Nature 607, 492–498 (2022).

A. Aghebat Rafat*, S. Sagredo*, M. Thalhammer & F. C. Simmel, Barcoded DNA origami structures for multiplexed optimization and enrichment of DNA-based protein-binding cavities, Nature Chemistry 12, 852-859 (2020).

L. Oesinghaus, F. C. Simmel, Switching the activity of Cas12a using guide RNA strand displacement circuits, Nature Communications 10, 2092 (2019).

A. Dupin, F. C. Simmel, Signalling and differentiation in emulsion-based multi-compartmentalized in vitro gene circuits, Nature Chemistry 11, 32–39 (2019).

J. Chao, J. Wang, F. Wang, X. Ouyang, E. Kopperger, H. Liu, Q. Li, J. Shi, L. Wang, J. Hu, L. Wang, W. Huang, F. C. Simmel, C. Fan, Solving mazes with single-molecule DNA navigators, Nature Materials 18, 273-279 (2019).

L. Aufinger, F. C. Simmel, Artificial Gel-based Organelles for Spatial Organization of Cell-free Gene Expression Reactions, Angew. Chem. Int. Ed. 57, 17245-17248 (2018).

K. Vogele, T. Frank, L. Gasser, M. A. Goetzfried, M. W. Hackl, S. A. Sieber, F. C. Simmel, and Tobias Pirzer, Towards synthetic cells using peptide-based reaction compartments, Nature Communications 9, 3862:1–7 (2018).

E. Kopperger, J. List, S. Madhira, F. Rothfischer, D. C. Lamb, and F. C. Simmel, A self-assembled nanoscale robotic arm controlled by electric fields, Science 359, 296–301 (2018).

G. Pardatscher, D. Bracha, O. Vonshak, S. S. Daube, F. C. Simmel, R. H. Bar-Ziv, DNA condensation in one dimension, Nature Nanotechnology 11,1076–1081 (2016).

M. Weitz,  J. Kim, K. Kapsner, E. Winfree, E. Franco, F. C. Simmel, Diversity in the dynamical behaviour of a compartmentalized programmable biochemical oscillator, Nature Chemistry 6, 295-302 (2014).

M. Langecker, V. Arnaut, T. G. Martin, J.List, S. Renner, M. Mayer, H. Dietz, F. C. Simmel, Synthetic lipid membrane channels formed by designed DNA nanostructures, Science 338, 932-936 (2012).

A. Kuzyk, R. Schreiber, Z. Fan, A. Högele, F. C. Simmel, A. Govorov, T. Liedl,  Chiral Plasmonic Nanostructures Self-assembled by DNA Origami Show Strong Circular Dichroism in the Visible, Nature 483, 311-314 (2012).

E. Franco, E. Friedrichs, J. Kim, R. Jungmann, R. Murray, E. Winfree, F. C. Simmel, Timing molecular production and motion with a synthetic transcriptional clock, Proc. Natl. Acad. Sci. USA 108, E784-E793 (2011).

R. Jungmann, C. Steinhauer, M. Scheible, A. Kuzyk, P. Tinnefeld, F. C. Simmel,Single-molecule kinetics and super-resolution microscopy by fluorescence imaging of transient binding on DNA origami, Nano Letters 10, 4756-4761 (2010).

C. Steinhauer, R. Jungmann, T. Sobey, F. C. Simmel, P. Tinnefeld, DNA Origami as a Nanoscopic Ruler for Super-Resolution Microscopy, Angewandte Chemie Int. Ed. 48, 8870-8873(2009).

W. U. Dittmer, A. Reuter and F. C. Simmel, A DNA-based machine that can cyclically bind and release thrombin, Angewandte Chemie Int. Ed. 43, 3550-3553 (2004).

A. J. Turberfield, J. C. Mitchell, B. Yurke, A. P. Mills Jr., M. I. Blakey and F. C. Simmel, DNA fuel for free-running nanomachines, Physical Review Letters 90, 118102 (2003).

B. Yurke, A. J. Turberfield, A. P. Mills Jr, F. C. Simmel and J. L. Neumann,
A DNA-fuelled molecular machine made of DNA, Nature 406, 605-608 (2000).