Publications

ORCID: https://orcid.org/0000-0003-1277-9608

Nicole Strittmatter‬ - ‪Google Scholar‬ Strittmatter, Nicole - Scopus

2024

Wei Chen, Min Qiu, Petra Paizs, James Kinross, Robert Goldin, Monica Rebec, Zoltan Takats, James McKenzie*, Nicole Strittmatter*. Universal, untargeted detection of bacteria in human tissues using spatial metabolomics (Preprint). DOI: 10.21203/rs.3.rs-3958736/v1 *shared correspondence

2023

Heffernan D and Pilz M, Klein M, Haack M, Race AM, Brück T, Qoura F, Strittmatter N. Screening of volatile organic compounds (VOCs) from liquid fungal cultures using ambient mass spectrometry. Analytical and Bioanalytical Chemistry 2023 (in print). DOI: 10.1007/s00216-023-04769-6.
Dannhorn A, Doria ML, McKenzie J, Inglese P, Swales JG, Hamm G, Strittmatter N, Maglennon G, Ghaem-Maghami S, Goodwin RJA, Takats Z. Targeted desorption electrospray ionization mass spectrometry imaging for drug distribution, toxicity and tissue classification studies. Metabolites 2023, 13(3), 377, DOI: 10.3390/metabo13030377.
Grashei M, Wodtke P, Skinner JG, Sühnel S, Setzer N, Metzler T, Gulde S, Park M, Mohr H, Hundshammer C, Strittmatter N, Pellegata N, Steiger K, Schilling F. Simultaneous Magnetic Resonance Imaging of pH, Perfusion and Renal Filtration using Hyperpolarized ¹³C-labelled Z-OMPD. Nature Communications 2023, 14(1), 5060, DOI: 10.1038/s41467-023-40747-3
Park M., Casini A, Strittmatter N., Seeing the invisible: Preparative strategies to visualise elusive molecules using mass spectrometry imaging. Trends in Analytical Chemistry 2023, 168, 117304, DOI:
10.1016/j.trac.2023.117304

2022

Strittmatter N and Richards FM, Race AM, Ling S, Sutton D, Nilsson A, Wallez Y, Barnes J, Maglennon G, Gopinathan A, Brais R, Wong E, Serra MP, Atkinson J, Smith A, Wilson J, Hamm G, Johnson TI, Dunlop CR, Kaistha BP, Andren PE, Lau A, Barry ST, Jodrell DI, Goodwin RJA. Method To Visualize the Intratumor Distribution and Impact of Gemcitabine in Pancreatic Ductal Adenocarcinoma by Multimodal Imaging, Analytical Chemistry 2022, 94(3), 1795-1803. DOI: 10.1021/acs.analchem.1c04579
StrittmatterN, MossJI, RaceAM, SuttonD, Rodriguez CanalesJ, Ling S, WongE, WilsonJ, SmithA, HowesC, BunchJ, BarryST, GoodwinRJA, AshfordMB. Understanding nanomedicine distribution using multimodal molecular imaging, Theranostics 2022, 12(5):2162-2174. DOI:https://doi.org/10.7150/thno.68000
Dannhorn A, Kazanc E, Hamm G, Swales J, Strittmatter N, Maglennon G, Goodwin RJA, Takats Z. Correlating mass spectrometry imaging and liquid chromatography-tandem mass spectrometry for tissue-based pharmacokinetic studies. Metabolites 2022, 12(3), 261. DOI: doi.org/10.3390/metabo12030261
Hulme H, Meikle LM, Strittmatter N, Swales J, Hamm G, Brown SL, Milling S, MacDonald AS, Goodwin RJA, Burchmore B, Wall D. Mapping the Influence of the Gut Microbiota on Small Molecules across the Microbiome Gut Brain Axis. Journal of the American Society of Mass Spectrometry 2022, 33(4), 649-659. DOI:https://doi.org/10.1021/jasms.1c00298
Illes-Toth E, Hale OJ, Hughes JW, Strittmatter N, Rose J, Clayton B, Sargeant R, Jones S, Dannhorn A, Goodwin RJA, Cooper HJ. In situ detection and imaging of a non-covalent protein-drug complex in tissue from orally-dosed rats. Angewandte Chemie Int. Ed. 2022, 61(36), e202202075. DOI: doi.org/10.1002/anie.202202075
Adua AJ, Arnal-Estape A, Zhao M, Qi B, Liu ZZ, Kravitz C, Hulme H, Strittmatter N, Lopez-Giraldez F, Albert AE, Melnick M, Politi K, Chiang V, Colclough N, Goodwin RJA, Smith P, Cross D, Nguyen DX. Brain Metastatic Outgrowth and Osimertinib Resistance are linked via RhoA in EGFR mutant Lung Cancer, Nature Communications 2022, 13 (1), 7690. DOI: doi.org/10.1038/s41467-022-34889-z
Dannhorn A, Swales JG, Hamm G, Strittmatter N, Kudo H, Maglennon G, Goodwin RJA, Takats Z. Evaluation of formalin-fixed and FFPE tissues for spatially resolved metabolomics and drug distribution studies. Pharmaceuticals 2022, 15(11). 1307. DOI: doi.org/10.3390/ph15111307
Invited Book Review for Analytical and Bioanalytical Chemistry on Tiffany Porta Siegel (Ed.): MALDI mass spectrometry imaging: from fundamentals to spatial omics. DOI: doi.org/10.1007/s00216-022-04127-y

2021

Strittmatter N and Kanvatirth P, Inglese P, Race AM, Nilsson A, Dannhorn A, Ling S, Wong E, Seeliger F, Serra MP, Hoffmann S, Maglennon G, Atkinson J, Jones S, Hamm G, Bunch J, Andren P, Takats Z, Goodwin R, Mastroeni P. Studying the effects of Salmonella typhimurium infection and ciprofloxacin treatment using mass spectrometry imaging, Journal of the American Society of Mass Spectrometry 2021, 32, 12, 2791–2802. DOI: doi.org/10.1021/jasms.1c00240
Strittmatter N, England R, Moss J, Race AM, Sutton D, Maglennon G, Ling S, Wong E, Rose J, McDonald R, Jones S, Ashford M, Goodwin RJA. Method to investigate the distribution of water-soluble compounds in fresh frozen tissues using imaging mass cytometry, Analytical Chemistry 2021, 93, 8, 3742–3749. DOI: doi.org/10.1021/acs.analchem.0c03908
Colclough N, Chen K, Johnstöm P, Strittmatter N, Yan Y, Wrigley GL, Schou M, Goodwin R, Varnäs K, Adua S, Zhao M, Nguyen DX, Maglennon G, Barton P, Atkinson J, Han L, Zhang D, Zhang Z, Janefeldt A, Wilson J, Smith A, Takano A, Arakawa R, Kondrashov M, Malmquist J, Revunov E, Vazquez-Romero A, Mahdi Moein M, Windhorst AD, Karp NA, Finlay MRV, Ward R, Yates JWT, Smith P, Farde L, Cross DAE. Preclinical comparison of the blood brain barrier (BBB) permeability of osimertinib with other EGFR TKIs. Clinical Cancer Research 2021, 27(1), 189-201. DOI: doi.org/10.1158/1078-0432.CCR-19-1871
Dannhorn A, Ling S, Powell S, McCall E, Maglennon G, Jones G, Pierce A, Strittmatter N, Hamm G, Barry S, Bunch J, Goodwin R, Takats Z. Evaluation of UV-C decontamination of clinical tissue sections for spatially resolved analysis by mass spectrometry imaging (MSI). Analytical Chemistry 2021, 93(5), 2767-2775. DOI: doi.org/10.1021/acs.analchem.0c03430
Race AM, Sutton D, Hamm G, Maglennon G, Morton JP, Strittmatter N, Campbell A, CRUK Grand Challenge Rosetta Consortium, Sansom OJ, Wang Y, Barry ST, Bunch J, Goodwin RJA. Deep learning-based annotation transfer between molecular imaging modalities: A route to multi-modal data integration. Analytical Chemistry 2021, 93(6), 3061-3071. DOI: doi.org/10.1021/acs.analchem.0c02726
Shariatgorji R, Nilsson A, Fridjonsdottir E, Strittmatter N, Dannhorn A, Svenningsson P, Goodwin RJA, Odell L, Andrén PE. Spatial visualization of comprehensive brain neurotransmitter systems and neuroactive substances by selective in situ chemical derivatization mass spectrometry imaging. Nature Protocols 2021, 16, 3298–3321. DOI: doi.org/10.1038/s41596-021-00538-w
Hulme H, Meikle LM, Strittmatter N, Swales J, Hamm G, Brown SL, Milling S, MacDonald AS, Goodwin RJA, Burchmore B, Wall D. Mapping the influence of the gut microbiota on small molecules in the brain through mass spectrometry imaging. BioRxiv 2020, DOI: doi.org/10.1101/2020.03.13.987164 
Ormsby MJ, Hulme H, Villar VH, Hamm G, Rodriguez-Blanco G, Bragg RA, Stittmatter N, Schofield CJ, Delles C, Salt IP, Tardito S, Burchmore R, Goodwin RJA, Wall DM. Microbiome-derived metabolites reproduce the mitochondrial dysfunction and decreased insulin sensitivity observed in type 2 diabetes, bioRxiv 2020, DOI: doi.org/10.1101/2020.08.02.232447

2020

Hulme H, Meikle LM, Strittmatter N, van der Hooft JJJ, Swales J, Bragg RA, Villar VH, Ormsby M, Barnes S, Brown SL, Dexter A, Kamat MT, Komen JC, Walker D, Milling S, Osterweil E, MacDonald AS, Schofield CJ, Tardito S, Bunch J, Douce G, Edgar JM, Edrada-Ebel R, Goodwin RJA, Burchmore R, Wall DM, Microbiome-derived carnitine mimics as novel mediators of gut-brain axis communication. Science Advances 2020, 6(11), eaax6328. DOI: doi.org/10.1126/sciadv.aax6328
Moss JI, Barjat H, Emmas SA, Strittmatter N, Maynard J, Goodwin RJA, Storm G, Lammers T, Puri S, Ashford MB, Barry ST. High-resolution 3D visualization of nanomedicine distribution in tumors. Theranostics 2020, 10(2), 880-897. DOI: doi.org/10.7150/thno.37178
Hamm GR, Bäckström E, Brülls M, Nilsson A, Strittmatter N, Andrén PE, Grime K, Fridén M, Goodwin RJA. Revealing the Regional Localization and Differential Lung Retention of Inhaled Compounds by Mass Spectrometry Imaging. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 2020, 33(1), 43-53. DOI: doi.org/10.1089/jamp.2019.1536
Abbassi-Ghadi N, Antonowicz S, McKenzie J, Kumar S, Huang J, Jones E, Strittmatter N, Petts G, Kudo H, Court S, Hoare J, Veselkov K, Goldin R, Takáts Z, Hanna G. De novo lipogenesis alters the phospholipidome of esophageal adenocarcinoma. Cancer Research 2020, 80(13), 2764-2774, DOI: doi.org/10.1158/0008-5472.CAN-19-4035
Dannhorn A, Kazanc E, Ling S, Nikula C, Karali E, Serra MP, Vorng JL, Inglese P, Maglennon G, Hamm G, Swales J, Strittmatter N, Poulogiannis G, Bunch J, Goodwin RJA, Takats Z. Universal sample preparation unlocking multimodal molecular tissue imaging, Analytical Chemistry 2020, 92(16), 11080-11088, DOI: doi.org/10.1021/acs.analchem.0c00826
Shariatgorji R, Nilsson A, Strittmatter N, Vallianatou T, Zhang X, Svenningsson P,Goodwin R, Andrén PE, Bromopyrylium derivatization facilitates identification by mass spectrometry imaging of monoamine neurotransmitters and small molecule neuroactive compounds. Journal of the American Society of Mass Spectrometry 2020, 31(12), 2553-2557, DOI: doi.org/10.1021/jasms.0c00166

2019

Davison AS and Strittmatter N, Sutherland H, Hughes AT, Hughes J, Bou-Gharios G, Milan AM, Goodwin RJA, Ranganath LR, Gallagher JA. Assessing the effect of nitisinone induced hypertyrosinaemia on monoamine neurotransmitters in brain tissue from a murine model of alkaptonuria using mass spectrometry imaging. Metabolomics 2019, 15(5), 68. DOI: doi.org/10.1007/s11306-019-1531-4

2018

Swales JG, Dexter A, Hamm G, Nilsson A, Strittmatter N, Michopoulos F, Hardy C, Morentin-Gutierrez P, Mellor M, Andren PE, Clench MR, Bunch J, Critchlow SE, Goodwin RJA. Quantitation of endogenous metabolites in mouse tumors using mass-spectrometry imaging, Analytical Chemistry 2018, 90(10), 6051-6058. DOI: doi.org/10.1021/acs.analchem.7b05239
Vallianatou T, Strittmatter N, Nilsson A, Shariatgorji M, Hamm G, Pereira M, Källback P, Svenningsson P, Karlgren M, Goodwin RJA, Andren P. A mass spectrometry imaging approach for investigating how drug-drug interactions influence drug blood-brain barrier permeability. Neuroimage 2018, 172, 808-816. DOI: doi.org/10.1016/j.neuroimage.2018.01.013
Bäckström E, Hamm G, Nilsson A, Fihn BM, Strittmatter N, Andrén P, Goodwin RJA, Fridén M. Uncovering the regional localization of inhaled salmeterol retention in the lung, Drug Delivery 2018, 25(1), 838-845. DOI: doi.org/10.1080/10717544.2018.1455762
Inglese P, Strittmatter N, Doria ML, Mroz AK, Speller AVM, Poynter L, Dannhorn A, Kudo H, Mirnezami R, Goldin RD, Nicholson JK, Takats Z, Glen RC. Network analysis of mass spectrometry imaging data from colorectal cancer identifies key metabolites common to metastatic development. bioRxiv 2018. DOI: doi.org/10.1101/230052
Varshavi D, Scott FH, Varshavi D, Veeravalli S, Phillips IR, Veselkov K, Strittmatter N, Takats Z, Shephard EA, Everett JR. Metabolic biomarkers of ageing in C57BL/6J wild-type and flavin-containing monooxygenase 5 (FMO5)-knockout mice. Frontiers in Molecular Biosciences 2018, 5, 28. DOI: doi.org/10.3389/fmolb.2018.00028

2017

England RM, Hare JI, Barnes J, Wilson J, Smith A, Strittmatter N, Kemmitt PD, Waring MJ, Barry ST, Alexander C, Ashford MB. Tumour regression and improved gastrointestinal tolerability from controlled release of SN-38 from novel polyoxazoline-modified dendrimers. Journal of Controlled Release 2017, 247, 73–85. DOI: doi.org/10.1016/j.jconrel.2016.12.034
Hulme HE, Meikle LM, Wessel H, Strittmatter N, Swales J, Thomson C, Nilsson A, Nibbs RJB, Milling S, Andren PE, Mackay CL, Dexter A, Bunch J, Goodwin RJA, Burchmore R and Wall DM. Mass spectrometry imaging identifies palmitoylcarnitine as an immunological mediator during Salmonella Typhimurium infection. Scientific Reports 2017, 7, 2786. DOI: doi.org/10.1038/s41598-017-03100-5
Galea D, Inglese P, Cammack L, Strittmatter N, Rebec M, Mirnezami R, Laponogov I, Kinross J, Nicholson JK, Takats Z & Veselkov KA. Translational utility of a hierarchical classification strategy in biomolecular data analytics. Scientific Reports 2017, 7, 14981. DOI: doi.org/10.1038/s41598-017-14092-7

2016

Strittmatter N and Lovrics A, Sessler J, McKenzie JS, Kucsma N, Szakacs G, Takats Z. Shotgun Lipidomic Characterization of the NCI60 Cell Line Panel Using Rapid Evaporative Ionization Mass Spectrometry. Analytical Chemistry 2016, 88 (15), 7507–7514. DOI: doi.org/10.1021/acs.analchem.6b00187
ShariatgorjiM and StrittmatterN, Nilsson A, Källback P, AlvarssonA, ZhangX, VallianatouT, SvenningssonP, GoodwinRJA, Andren PE. Simultaneous imaging of multiple neurotransmitters and neuroactive substances in the brain by desorption electrospray ionization mass spectrometry. NeuroImage 2016, 136, 129-138. DOI: doi.org/10.1016/j.neuroimage.2016.05.004
Swales JG, Strittmatter N, Tucker JW, Clench MR, Webborn PJH, Goodwin RJA. Spatial Quantitation of Drugs in tissues using Liquid Extraction Surface Analysis Mass Spectrometry Imaging. Scientific Reports 2016, 6, 37648. DOI: 10.1038/srep37648
Abbassi-Ghadi N, Golf O, Kumar S, Antonowicz SSA, McKenzie JS, Huang J, Strittmatter N, Kudo H, Jones EA, Veselkov KA, Goldin RD, Hanna GB, Takats Z. Imaging of Esophageal Lymph Node Metastases by Desorption Electrospray Ionization Mass Spectrometry. Cancer Research 2016, 76(19), 5647-5656. DOI: doi.org/10.1158/0008-5472.CAN-16-0699
Dória ML, McKenzie JS, Mroz AK, Phelps DL, Speller AVM, Rosini F, Strittmatter N, Golf OH, Veselkov KA, Brown R, Ghaem-Maghami S, Takats Z. Epithelial ovarian carcinoma diagnosis by desorption electrospray ionization mass spectrometry imaging, Scientific Reports 2016, 6, 39219. DOI: doi.org/10.1038/srep39219
Ashton S, Song YH, Nolan J_,Cadogan E, Murray J, Odedra R, Foster J, HallP, Low S, TaylorP, EllstonR, Polanska U, Wilson J, Howes C, Smith A, GoodwinRJA, Swales JG, Strittmatter N, Takáts Z, Nilsson A, Andren P, TruemanD, Walker M, Reimer CL, TroianoG, Parsons D, De Witt D, Ashford M, Hrkach J, Zale S, Jewsbury S,Barry ST. Aurora kinase inhibitor nanoparticles target tumors with favorable therapeutic index in vivo. Science Translational Medicine 2016, 325(8), p325ra17. DOI: doi.org/10.1126/scitranslmed.aad2355

2015

Liebeke M, Strittmatter N, Fearn S, Morgan AJ, Kille P, Fuchser J, Wallis D, Palchykov V, Robertson J, Lahive E, Spurgeon DJ, McPhail D, Takats Z, Bundy JG. Unique metabolites protect earthworms against plant polyphenols. Nature Communications 2015, DOI: doi.org/10.1038/ncomms8869
Golf O, Strittmatter N, Karancsi T, Pringle SD, Speller AV, Mroz A, Kinross JM, Abbassi-Ghadi N, Jones EA, Takats Z. Rapid evaporative ionization mass spectrometry imaging platform for direct mapping from bulk tissue and bacterial growth media. Analytical Chemistry 2015, 87(5): 2527-34. DOI: doi.org/10.1021/ac5046752
Abbassi-Ghadi N, Jones EA, Veselkov KA, Huang J, Kumar S, Strittmatter N, Golf O, Kudo H, Goldin RD, Hanna GB, Takats Z. Repeatability and reproducibility of desorption electrospray ionization-mass spectrometry (DESI-MS) for the imaging analysis of human cancer tissue: a gateway for clinical applications. Analytical Methods 2015, 7: 71-80. DOI: doi.org/10.1039/C4AY01770F
Guenther S, Muirhead LJ, Speller AV, Golf O, Strittmatter N, Ramakrishnan R, Goldin RD, Jones EA, Veselkov K, Darzi A, Takats Z. Spatially resolved metabolic phenotyping of breast cancer by desorption electrospray ionization mass spectrometry. Cancer Research 2015. DOI: doi.org/10.1158/0008-5472.CAN-14-2258
Oetjen J, Veselkov K, Watrous J, McKenzie JS, Becker M, Hauberg-Lotte L, Kobarg JH, Strittmatter N, Mróz AK, Hoffmann F, Trede D, Palmer A, Schiffler S, Steinhorst K, Aichler M, Goldin R, Guntinas-Lichius O, von Eggeling F, Thiele H, Maedler K, Walch A, Maass P, Dorrestein PC, Takats Z, Alexandrov T. Benchmark datasets for 3D MALDI- and DESI-imaging mass spectrometry. GigaScience 05/2015. DOI: doi.org/10.1186/s13742-015-0059-4

2014

Strittmatter N, Rebec M, Jones EA, Golf O, Abdolrasouli A, Balog J, Behrends V, Veselkov KA, Takats Z. Characterization and identification of clinically relevant microorganisms using rapid evaporative ionization mass spectrometry. Analytical Chemistry 2014, 86(13): 6555-62. DOI: doi.org/10.1021/ac501075f
Swales JG, Tucker JW, Strittmatter N, Nilsson A, Cobice D, Clench MR, Mackay CL, Andren PE, Takáts Z, Webborn PJ. Mass spectrometry imaging of cassette-dosed drugs for higher throughput pharmacokinetic and biodistribution analysis. Analytical Chemistry 2014, 86(16): 8473-80. DOI: doi.org/10.1021/ac502217r
Veselkov KA, Mirnezami R, Strittmatter N, Goldin RD, Kinross J, Speller AVM, Abramov T, Jones EA, Darzi A, Holmes E, Nicholson JK, Takats Z. Chemo-informatic strategy for imaging mass spectrometry-based hyperspectral profiling of lipid signatures in colorectal cancer. Proceedings of the National Academy of Sciences of the United States of America 2014, 111(3): 1216-21. DOI: doi.org/10.1073/pnas.1310524111
Abbassi-Ghadi N, Veselkov KA, Kumar S, Huang J, Jones EA, Strittmatter N, Kudo H, Goldin RD, Takáts Z, Hanna GB. Discrimination of lymph node metastases using desorption electrospray ionisation-mass spectrometry imaging. Chemical Communications 2014, 50(28): 3661-4. DOI: doi.org/10.1039/c3cc48927b

2013

Strittmatter N, Jones EA, Veselkov KA, Rebec M, Bundy JG, Takats Z. Analysis of intact bacteria using rapid evaporative ionisation mass spectrometry. Chemical Communications 2013, 49(55):6188-90. DOI: doi.org/10.1039/c3cc42015a

2012

Strittmatter N, Duering RA, Takats Z, Analysis of wastewater samples by direct combination of thin-film microextraction and desorption electrospray ionization mass spectrometry. Analyst 2012, 137(17), 4037-4044. DOI: doi.org/10.1039/C2AN35411J