Publications in Scientific Journals

1 equal contribution
* correspondence


Zanotti A1, Coelho JPL1, Kaylani D, Singh G, Tauber M, Hitzenberger M, Avci D, Zacharias M, Russel RB, Lemberg MK*, Feige MJ*

The human signal peptidase complex acts as a quality control enzyme for membrane proteins

Science 2022, 378(6623):996-1000.

presse release

Blömeke N, Meighen-Berger K, Hitzenberger M, Bach NC, Parr M, Coelho JPL, Frishman D, Zacharias M, Sieber SA, Feige MJ*

Intra-membrane client recognition potentiates the chaperone functions of Calnexin

EMBO J 2022, in press.

Mideksa YG1, Aschenbrenner I1, Fux A, Kaylani D, Weiß CAM, Nguyen TA, Bach NC, Lang K, Sieber SA, Feige MJ*

A comprehensive set of ER protein disulfide isomerase family memberssupports the biogenesis of pro-inflammatory interleukin 12 family cytokines

J Biol Chem 2022, in press.

Hildenbrand K1, Aschenbrenner I1, Franke FC1, Devergne O*, Feige MJ*

Biogenesis and engineering of interleukin 12 family cytokines
Trends Biochem Sci 2022, 47(11):936-949.


Kong KYE, Coelho JPL, Feige MJ, Khmelinskii A*

Quality control of mislocalized and orphan proteins
Exp Cell Res 2021, 403(2):112617.

Min B*, Kim D, Feige MJ

IL-30 (IL-27A): a familiar stranger in immunity, inflammation, and cancer
Exp Mol Med 2021, 53(5):823-834.

Fauser J, Gulen B, Pogenberg V, Pett C, Pourjafar-Dehkordi D, Krisp C, Höpfner D, König G, Schlüter H, Feige MJ,

Zacharias M, Hedberg C*, Itzen A*

Specificity of AMPylation of the human chaperone BiP is mediated by TPR motifs of FICD
Nature Communications 2021, 12(1):2426.

Schlagintweit JF1, Jakob CHG1, Meighen-Berger K, Gronauer TF, Weigert Muñoz A, Weiß V, Feige MJ, Sieber SA,

Correia JDG, Kühn FE*

Fluorescent palladium(II) and platinum(II) NHC/1,2,3-triazole complexes: antiproliferative activity and selectivity against cancer cells
Dalton Trans 2021, 50(6):2158-2166.


Bohnacker S1, Hildenbrand K1, Aschenbrenner I1, Müller SI, Esser-von Bieren J*, Feige MJ*
Influence of glycosylation on IL-12 family cytokine biogenesis and function
Mol Immunol 2020, 126:120-128.
Cave MC, Maillard S, Hildenbrand K, Mamelonet C, Feige MJ, Devergne O*
Glycosaminoglycans bind human IL-27 and regulate its activity
Eur J Immunol 2020, 50(10):1484-1499.
Coelho JPL, Feige MJ*
In case of stress, hold tight: phosphorylation switches PDI from an oxidoreductase to a holdase, tuning ER proteostasis
EMBO J 2020, 39(10).
de los Reyes Jimenez M1, Lechner A1, Alessandrini F, Bohnacker S, Schindela S, Trompette A, Haimerl P, Thomas D, Henkel F, Mourao A, Geerlof A, Prazeres de Costa C, Chaker AM, Brüne B, Nüssing R, Jakobsson, PJ, Nockher WA, Feige MJ, Haslbeck M, Ohnmacht C, Marsland BJ, Voehringer D, Harris NL, Schmidt-Weber CB, Esser-von Bieren J*
An anti-inflammatory eicosanoid switch mediates the suppresion of type-2 inflammation by helminth larval products
Science Translational Medicine 2020, 12(540).
Mideksa YG, Fottner M, Braus S, Weiß CAM, Nguyen TA, Meier S, Lang K, Feige MJ*
Site-specific protein labeling with fluorophores as a tool to monitor protein turnover
ChemBioChem 2020, 21(13):1861-1867.
Niu Z, Prade E, Malideli E, Hille K, Jussupow A, Mideksa YG, Yan LM, Qian C, Fleisch M, Messias AC, Sarkar R, Sattler S, Lamb DC, Feige MJ, Camilloni C, Kapurniotu A*, Reif B*
Structural insights into IAPP-derived amyloid inhibitors and their mechanism of action
Angewandte Chemie 2020, 59(14):5771-5781.


Hennig J*, Feige MJ*
Highlight: Young research groups in Germany - continued
Biol Chem 2019, 400(11):1395.

Meier S, Bohnacker S, Klose CJ, Lopez A, Choe CA, Schmid PWN, Bloemeke N, Rührnößl F, Haslbeck M, Esser-von Bieren J, Sattler M, Huang PS, Feige MJ*

The molecular basis of chaperone-mediated interleukin 23 assembly control
Nature Communications 2019, 10:4121.

presse release

Hennig J*, Feige MJ*
Highlight: Young research groups in Germany
Biol Chem 2019, 400(7):811-812.
Müller SI1, Aschenbrenner I1,  Zacharias M*, Feige MJ*
An interspecies analysis reveals molecular construction principles of interleukin 27
J Mol Biol 2019, 431(12):2383-2393.

Hohl A*, Mideksa YG, Akal A, Karan R, Vogler M, Groll M, Rueping M, Lang K, Feige MJ, Eppinger J*
Genetically encoded biotin analogs: Incorporation and application in bacterial and mammalian cells
ChemBioChem 2019, 20(14):1795-1798.

Coelho JPL, Stahl M, Bloemeke N, Meighen-Berger K, Piedrafita Alvira C, Zhang ZR, Sieber SA, Feige MJ*
A network of chaperones prevents and detects failures in membrane protein lipid bilayer integration
Nature Communications 2019, 10:672.

Müller SI, Friedl A, Aschenbrenner I, Esser-von Bieren J, Zacharias M, Devergne O*, Feige MJ*
A folding switch regulates interleukin 27 biogenesis and secretion of its alpha subunit as a cytokine
Proc Natl Acad Sci U S A 2019, 116(5):1585-1590.

press release


Grötsch RK1, Angi A1, Mideksa YG, Wanzke C, Tena-Solsona M, Feige MJ, Rieger B, Boekhoven J*
Dissipative Self-Assembly of Photoluminescent Silicon Nanocrystals
Angewandte Chemie 2018, 57(44):14608-14612.

Rodriguez Camargo DC, Garg D, Buday K, Franko A, Rodriguez Camargo A, Schmidt F, Cox SJ, Suladze S, Haslbeck M, Mideksa YG, Gemmecker G, Aichler M, Mettenleiter G, Schulz M, Walch AK, Hrabě de Angelis M, Feige MJ, Sierra CA, Conrad M, Tripsianes K, Ramamoorthy A, Reif B*
hIAPP forms toxic oligomers in plasma
Chem Commun 2018, 54(43):5426-5429.


Reitberger S, Haimerl P, Aschenbrenner I, Esser-von Bieren J, Feige MJ*
Assembly-induced folding regulates interleukin 12 biogenesis and secretion.
J Biol Chem 2017, 292(19):8073-8081.


Behnke J1, Mann M1, Scruggs FL, Feige MJ*, Hendershot LM*
Members of the Hsp70 family recognize distinct types of sequences to execute ER quality control.
Mol Cell 2016, 63(5):739-752.


Feige MJ*, Behnke J, Mittag T, Hendershot LM*
Dimerization-dependent folding underlies assembly control of the clonotypic αβT cell receptor chains.
J Biol Chem 2015, 290(44):26821-31.
Behnke J1, Feige M1, Hendershot LM*
BiP and Its Nucleotide Exchange Factors Grp170 and Sil1: Mechanisms of Action and Biological Functions.
J Mol Biol 2015, 427(7):1589-1608.


Otero JH1, Lizák B1, Feige MJ, Hendershot LM*
Dissection of structural and functional requirements that underlie the interaction of ERdj3 protein with substrates in the endoplasmic reticulum.
J Biol Chem 2014, 289(40):27504-12.
Feige MJ*, Buchner J*
Principles and engineering of antibody folding and assembly.
Biochim Biophys Acta 2014, 1844(11):2024-31.
Feige MJ1,*, Gräwert MA1,, Marcinowski M1,, Hennig J1,, Behnke J, Ausländer D, Herold EM, Peschek J, Castro CD, Flajnik M, Hendershot LM, Sattler M, Groll M, Buchner J.
The structural analysis of shark IgNAR antibodies reveals evolutionary principles of immunoglobulins.
Proc Natl Acad Sci U S A 2014, 111(22):8155-60.


Feige MJ*, Hendershot LM*
Quality control of integral membrane proteins by assembly-dependent membrane integration.
Mol Cell 2013, 51(3):297-309.
Hendershot LM*, Feige MJ*, Buchner J*
Acidification activates ERp44--a molecular litmus test for protein assembly.
Mol Cell 2013, 50(6):779-81.
Marcinowski M, Rosam M, Seitz C, Elferich J, Behnke J, Bello C, Feige MJ, Becker CF, Antes I*, Buchner J*
Conformational selection in substrate recognition by Hsp70 chaperones.
J Mol Biol 2013, 425(3):466-74.


Howes J, Shimizu Y, Feige MJ, Hendershot LM*
C-terminal mutations destabilize SIL1/BAP and can cause Marinesco-Sjögren syndrome.
J Biol Chem 2012, 287(11):8552-60.


Marcinowski M1, Höller M1, Feige MJ, Baerend D, Lamb DC*, Buchner J*
Substrate discrimination of the chaperone BiP by autonomous and cochaperone-regulated conformational transitions.
Nat Struct Mol Biol 2011, 18(2):150-8.
Feige MJ, Hendershot LM*
Disulfide bonds in ER protein folding and homeostasis.
Curr Opin Cell Biol 2011, 23(2):167-75.


Bertz M1, Chen J1, Feige MJ, Franzmann TM, Buchner J*, Rief M*
Structural and mechanical hierarchies in the alpha-crystallin domain dimer of the hyperthermophilic small heat shock protein Hsp16.5.
J Mol Biol 2010, 400(5):1046-56.
Feige MJ1, Simpson ER1, Herold EM1, Bepperling A, Heger K, Buchner J*
Dissecting the alternatively folded state of the antibody Fab fragment.
J Mol Biol 2010, 399(5):719-30.
Chen J, Feige MJ, Franzmann TM, Bepperling A, Buchner J*
Regions outside the alpha-crystallin domain of the small heat shock protein Hsp26 are required for its dimerization.
J Mol Biol 2010, 398(1):122-31.
Feige MJ, Hendershot LM*, Buchner J*
How antibodies fold.
Trend Biochem Sci 2010, 35(4):189-98.


Feige MJ1, Nath S1, Catharino SR, Weinfurtner D, Steinbacher S, Buchner J*
Structure of the murine unglycosylated IgG1 Fc fragment.
J Mol Biol 2009, 391(3):599-608.
Feige MJ, Groscurth S, Marcinowski M, Shimizu Y, Kessler H, Hendershot LM, Buchner J*
An unfolded CH1 domain controls the assembly and secretion of IgG antibodies.
Mol Cell 2009, 34(5):569-79.


Feige MJ1, Groscurth S1, Marcinowski M, Yew ZT, Truffault V, Paci E, Kessler H, Buchner J*
The structure of a folding intermediate provides insight into differences in immunoglobulin amyloidogenicity.
Proc Natl Acad Sci U S A 2008, 105(36):13373-8.
Feige MJ, Paci E*
Rate of loop formation in peptides: a simulation study.
J Mol Biol 2008, 382(2):556-65.


Feige MJ, Hagn F, Esser J, Kessler H, Buchner J*
Influence of the internal disulfide bridge on the folding pathway of the CL antibody domain.
J Mol Biol 2007, 365(4):1232-44.


Feige MJ, Walter S, Buchner J*
Folding mechanism of the CH2 antibody domain.
J Mol Biol 2004, 344(1):107-18.

Book Publications


Feige MJ, Braakman I, Hendershot LM
Disulfide bonds in protein folding and stability.
RSC Publishing 2018, Oxidative Folding of Proteins (edited bei MJ Feige).


Feige MJ, Buchner J
Oxidative Folding of Proteins in vitro.
RSC Publishing 2008, Oxidative Folding of Peptides and Proteins (edited by L Moroder and J Buchner).