NMR and integrative structural biology and structure-based drugdiscovery
We study the structure, molecular recognition and dynamics of biological macromolecules in solution using Nuclear Magnetic Resonance (NMR) spectroscopy.
NMR is combined in an integrative structural biology approach with X-ray crystallography, Small Angle X-ray and/or Neutron Scattering (SAXS/SANS), cryo-EM and biophysical techniques to understand molecular mechanisms of regulatory protein complexes in RNA-based gene regulation (e.g. alternative splicing and non-coding RNAs pathways), and cellular signaling (molecular chaperones, peroxisome biogenesis) in physiological and disease-linked pathways.
NMR and integrative structural biology are used to develop novel therapeutic approaches employing structure-based drug discovery of small molecule and RNA-based therapeutics.