Artificial Metalloenzymes and Photoenzymes
Our research focuses on the rational design and directed evolution of artificial metalloenzymes and photoenzymes. We aim to engineer novel biocatalysts and study their structure and molecular mechanism.
Enzymes are widely used as efficient, selective, and sustainable catalysts. However, the development of artificial enzymes for reactions that go beyond the nature’s synthetic repertoire remains a major challenge. We combine the versatility of transition metal catalysis and photocatalysis with the superb selectivity provided by proteins to generate novel enzymes. Catalyst optimization is done by directed evolution, a techniques that mimics natural selection in the laboratory.