Unsere Arbeitsgruppe war an folgenden Publikationen beteiligt


Mymrikov EV, Riedl M, Peters C, Weinkauf S, Haslbeck M, Buchner J. (2020) Regulation of small heat-shock proteins by hetero-oligomer formation. J Biol Chem. 295(1):158-169. doi: 10.1074/jbc.RA119.011143. PDF


Kaiser CJO, Peters C, Schmid PWN, Stavropoulou M, Zou J, Dahiya V, Mymrikov EV, Rockel B, Asami S, Haslbeck M, Rappsilber J, Reif B, Zacharias M, Buchner J, Weinkauf S. (2019) The structure and oxidation of the eye lens chaperone αA-crystallin. Nat Struct Mol Biol. 66(12):1141-1150. doi: 10.1038/s41594-019-0332-9. PDF

Haslbeck M, Weinkauf S, Buchner J. (2019) Small heat shock proteins: Simplicity meets complexity. J Biol Chem. 294(6):2121-2132. doi: 10.1074/jbc.REV118.002809. PDF


Haslbeck M, Peschek J, Buchner J, Weinkauf S. (2016) Structure and function of α-crystallins: Traversing from in vitro to in vivo. Biochim Biophys Acta. 1860(1 Pt B):149-66. doi: 10.1016/j.bbagen.2015.06.008. PDF


Mainz A, Peschek J, Stavropoulou M, Back KC, Bardiaux B, Asami S, Prade E, Peters C, Weinkauf S, Buchner J, Reif B. (2015) The chaperone αB-crystallin uses different interfaces to capture an amorphous and an amyloid client. Nat Struct Mol Biol. 22(11):898-905. doi: 10.1038/nsmb.3108.  PDF

Fleckenstein T, Kastenmüller A, Stein ML, Peters C, Daake M, Krause M, Weinfurtner D, Haslbeck M, Weinkauf S, Groll M, Buchner J. (2015) The Chaperone Activity of the Developmental Small Heat Shock Protein Sip1 Is Regulated by pH-Dependent Conformational Changes. Mol Cell. 58(6):1067-78. doi: 10.1016/j.molcel.2015.04.019. PDF


Peschek J, Braun N, Rohrberg J, Back KC, Kriehuber T, Kastenmüller A, Weinkauf S, Buchner J. (2013) Regulated structural transitions unleash the chaperone activity of αB-crystallin. Proc Natl Acad Sci U S A. 110(40):E3780-E3789. PDF


Bepperling A, Alte F, Kriehuber T, Braun N, Weinkauf S, Groll M, Haslbeck M, Buchner J. (2012) Alternative bacterial two-component small heat shock protein systems.  Proc Natl Acad Sci U S A. 109(50):20407-12. PDF

Gebendorfer KM, Drazic A, Le Y, Gundlach J, Bepperling A, Kastenmüller A, Ganzinger KA, Braun N, Franzmann TM, Winter J. (2012) Identification of a Hypochlorite-Specific Transcription Factor from Escherichia coli. J Biol Chem. 287(9):6892-903. PDF


Braun N, Zacharias M, Peschek J, Kastenmüller A, Zou J, Hanzlik M, Haslbeck M, Rappsilber J, Buchner J, Weinkauf S. (2011) Multiple molecular architectures of the eye lens chaperone  B-crystallin elucidated by a triple hybrid approach. Proc Natl Acad Sci U S A. 108(51):20491-6. PDF

Zeiler E, Braun N, Böttcher T, Kastenmüller A, Weinkauf S, Sieber SA. (2011) Vibralactone as a Tool to Study the Activity and Structure of the ClpP1P2 Complex from Listeria monocytogenes. Angew Chem Int Ed Engl.  50(46):11001-4.  PDF


Welker S, Rudolph B, Frenzel E, Hagn F, Liebisch G, Schmitz G, Scheuring J, Kerth A, Blume A, Weinkauf S, Haslbeck M, Kessler H, Buchner J. (2010) Hsp12 is an intrinsically unstructured stress protein that folds upon membrane association and modulates membrane function. Mol Cell. 39(4):507-20. PDF

de Oliveira JF, Wajnberg E, de Souza Esquivel DM, Weinkauf S, Winklhofer M, Hanzlik M. (2010) Ant antennae: are they sites for magnetoreception? J R Soc Interface. 7(42):143-52. PDF


Peschek J, Braun N, Franzmann T, Georgalis Y, Haslbeck M, Weinkauf S, Buchner J (2009) The eye lens chaperone α-crystallin forms defined globular assemblies. PNAS, 106(32)13272-7. PDF

Braun N, Weinkauf S. (2009) Einzelpartikel-3D-Elektronenmikroskopie: Analyse heterogener Proteinkomplexe. BIOspektrum. 01/09: 32-36. PDF


Rodríguez-Fernández L, López-Jaramillo FJ, Bacher A, Fischer M, Weinkauf S. (2008) Improvement of the quality of lumazine synthase crystals by protein engineering. Acta Crystallogr Sect F Struct Biol Cryst Commun. 64(Pt 7):625-8. PDF

Haslbeck M, Kastenmüller A, Buchner J, Weinkauf S, Braun N. (2008) Structural dynamics of archaeal small heat shock proteins. J Mol Biol. 378(2):362-74. PDF


Gliko O, Pan W, Katsonis P, Neumaier N, Galkin O, Weinkauf S, Vekilov PG. (2007) Metastable liquid clusters in super- and undersaturated protein solutions. J Phys Chem B. 111(12):3106-14. PDF

Janig E, Haslbeck M, Aigelsreiter A, Braun N, Unterthor D, Wolf P, Khaskhely NM, Buchner J, Denk H, Zatloukal K. (2007) Clusterin associates with altered elastic fibers in human photoaged skin and prevents elastin from ultraviolet-induced aggregation in vitro. Am J Pathol. 171(5):1474-82. PDF


Afonin S, Frey A, Bayerl S, Fischer D, Wadhwani P, Weinkauf S, Ulrich AS. (2006) The cell-penetrating peptide TAT(48-60) induces a non-lamellar phase in DMPC membranes. Chemphyschem. 7(10):2134-42. PDF

Meining W, Scheuring J, Fischer M, Weinkauf S. (2006) Cloning, purification, crystallization and preliminary crystallographic analysis of SecA from Enterococcus faecalis. Acta Crystallogr Sect F Struct Biol Cryst Commun. 62(Pt 6):583-5. PDF


Scheuring J, Braun N, Nothdurft L, Stumpf M, Veenendaal AK, Kol S, van der Does C, Driessen AJ, Weinkauf S. (2005) The oligomeric distribution of SecYEG is altered by SecA and translocation ligands. J Mol Biol. 25;354(2):258-271. PDF

Vojta A, Scheuring J, Neumaier N, Mirus O, Weinkauf S, Schleiff E. (2005) Determination of liposome size: a tool for protein reconstitution. Anal Biochem. 347(1):24-33. PDF

Gliko O, Neumaier N, Pan W, Haase I, Fischer M, Bacher A, Weinkauf S, Vekilov PG. (2005) A metastable prerequisite for the growth of lumazine synthase crystals. J. Am. Chem. Soc. J Am Chem Soc 127(10):3433-3438. PDF

Liang Y, Hanzlik M, Anwander R. (2005) PMO[KIT-5]-n: synthesis of highly ordered three-dimensional periodic mesoporous organosilicas with Fm3m symmetry. Chem. Commun. 4, 525–527. PDF

Maillard F, Schreier S, Hanzlik M, Savinova ER, Weinkauf S, Stimming U. (2005) Influence of particle agglomeration on the catalytic activity of carbon-supported Pt nanoparticles in CO monolayer oxidation. Phys. Chem. Chem. Phys. 7, 385-393. PDF


Sakthivel A, Zhao J, Hanzlik M, Kühn FE. (2004) Heterogenisation of CpMo(CO)3Cl on mesoporous materials and its application as olefin epoxidation catalyst. J. Chem. Soc., Dalton Trans. 20, 3338-3341. PDF

Haslbeck M, Braun N, Stromer T, Richter B, Model N, Weinkauf S, Buchner J. (2004) Hsp42 is the general small heat shock protein in the cytosol of Saccharomyces cerevisiae. EMBO J. 23, 638-649. PDF

Frühere Arbeiten

Hunt, J.F., Weinkauf, S., Henry, L., Fak, J.J., McNicholas, P., Oliver, D.B., Deisenhofer, J. (2002) Nucleotide control of interdomain interactions in the conformational reaction cycle of SecA. Science 297, 2018-2026.

Braun, N., Meining, W., Hars, U., Fischer, M., Ladenstein, R., Huber, R., Bacher, A., Weinkauf, S., Bachmann, L. (2002) Formation of metal nanoclusters on specific surface sites of protein molecules. J. Mol. Biol. 321, 341-353.

Weinkauf, S., Hunt, J.F., Scheuring, J., Henry, L., Fak, J., Oliver, D.B., Deisenhofer, J. (2001) Conformational stabilization and crystallization of the SecA translocation ATPase from Bacillus subtilis. Acta Crystallogr. D Biol. Crystallogr. 57, 559-565.

Scheuring, J., Kugelbrey, K., Weinkauf, S., Cushman, M. , Bacher, A., Fischer, M. (2001) 19F NMR ligand perturbation studies on 6,7-bis(trifluoromethyl)-8-ribityllumazine-7-hyd-rates and the lumazine synthase complex of Bacillus subtilis. Site-directed mutagenesis changes the mechanism and the stereoselectivity of the catalyzed haloform-type reaction. J. Org. Chem. 66, 3811-3819.

Wagner, M., Köhler, K., Djakovitch, L., Weinkauf, S., Hagen, V., Mühler, M. (2000) Heck reactions catalyzed by oxide-supported palladium - structure-activity relationships. Topics in Catalysis 13, 319-326.

Braun, N., Tack, J., Fischer, M., Bacher, A., Bachmann, L., Weinkauf, S. (2000) Electron microscopic observations on protein crystallization: adsorption layers, aggregates and crystal defects. J. Cryst. Growth 212, 270-282.

Ulrich, A.S., Tichelaar, W., Forster, G., Zschornig, O., Weinkauf, S., Meyer, H.W. (1999) Ultrastructural characterization of peptide-induced membrane fusion and peptide self-assembly in the lipid bilayer. Biophys J. 77, 829-841.

Meyer, H.W., Westermann, M., Stumpf, M., Richter, W., Ulrich, A.S., Hoischen, C. (1998) Minimal radius of curvature of lipid bilayers in the gel phase state corresponds to the dimension of biomembrane structures "caveolae". J Struc. Biol. 124, 77-87.

Mörtl, S., Fischer, M., Richter, G., Tack, J., Weinkauf, S., Bacher, A. (1996) Biosynthesis of riboflavin. Lumazine synthase of Escherichia coli. J. Biol. Chem. 271, 33201-33207.

Bacher, A., Fischer, M., Kis, K., Kugelbrey, K., Mörtl, S., Scheuring, J., Weinkauf, S., Eberhardt, S., Schmidt-Bäse, K., Huber,  R., Ritsert, K., Cushman, M., Ladenstein, R. (1996) Biosynthesis of riboflavin: structure and mechanism of lumazine synthase. Biochem. Soc Trans. 24, 89-94.

Nar, H., Huber, R., Meining, W., Bracher, A., Fischer, M., Hösl, C., Ritz, H., Schmid, C., Weinkauf, S., Bacher, A. (1996) Structure and mechanism of GTP cyclohydrolase I of Escherichia coli. Biochem. Soc Trans. 24, 37.

Meining W, Bacher A, Bachmann L, Schmid C, Weinkauf S, Huber R, Nar H. (1995) Elucidation of crystal packing by X-ray diffraction and freeze-etching electron microscopy. Studies on GTP cyclohydrolase I of Escherichia coli. J. Mol. Biol. 253, 208-218.

Nar, H., Huber, R., Meining, W., Schmid, C., Weinkauf, S., Bacher, A. (1995) Atomic structure of GTP cyclohydrolase I. Structure 3, 459-466.

Schmid, C., Meining, W., Weinkauf, S., Bachmann, L., Ritz, H., Eberhardt, S., Gimbel, W., Werner, T., Lahm, H.W., Nar, H., Huber, R., Bacher, A. (1993) Studies on GTP cyclohydrolase I of Escherichia coli. Adv. Exp. Med. Biol. 338, 157-162.

Bacher, A., Weinkauf, S., Bachmann, L., Ritsert, K., Baumeister, W., Huber, R., Ladenstein, R. (1992) Electron microscopy of decorated crystals for the determination of crystallographic rotation and translation parameters in large protein complexes. J. Mol. Biol. 225, 1065-1073.

Pühler, G., Weinkauf, S., Bachmann, L., Müller, S., Engel, A., Hegerl, R., Baumeister, W. (1992) Subunit stoichiometry and three-dimensional arrangement in proteasomes from Thermoplasma acidophilum. EMBO J. 11, 1607-1616.

Weinkauf, S., Bachmann, L. (1992) Metal decoration of biomacromolecules and molecular assemblies - a review. Ultramicroscopy 46, 113-134.

Weinkauf, S., Bacher, A., Baumeister, W., Ladenstein, R., Huber, R., Bachmann, L. (1991) Correlation of metal decoration and topochemistry on protein surfaces. J. Mol. Biol. 221, 637-645.

Bachmann, L., Weinkauf, S., Baumeister, W., Wildhaber, I., Bacher, A. (1989) Electron microscopy of subnanometer surface features on metal-decorated protein crystals. J. Mol. Biol. 207, 575-584.